29: Serology and Lab Testing in Rheumatic Dz

Question 1

two diseases that ESR are esp good for monitoring

Answer 1

polymyalgia rheumatica, giant cell arteritis

Question 2

what level of CRP is considred elevated

Answer 2

8+

Question 3

RF

Answer 3

an IgM Ab that targets the Fc portion of IgG

Question 4

what produces RF?

Answer 4

B cells in syovial joints of RA pts

Question 5

pts with nodular RA all have what?

Answer 5

RF

Question 6

higher levels of RF are associated with…?

Answer 6

more aggressive disease

Question 7

best tests for specificity for RA (combined)

Answer 7

ACCP + RF

Question 8

ANA

Answer 8

Abs against nuclear antigens (v broad)

Question 9

anti-histone Abs is found in what?

Answer 9

DIL

Question 10

anti-DS DNA found in what?

Answer 10

SLE

Question 11

anti centromere & anti SCL-70 Abs found in what?

Answer 11

CREST

Question 12

anti-streptolycin O Ab

Answer 12

had a prior strep infection, and strep can cause polyarticular arthritis in large joints

Question 13

best imaging study for bony abnormalities for RA**

Answer 13

CT

Question 14

five other areas of the body commonly affected when a pt has arthritides

Answer 14

1. skin
2. bowel
3. pulmonary
4. endocrine
5. ophthalmologic