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2: NMSP Exam 2 > Extras: Drugs > Flashcards

Extras: Drugs Flashcards

1
Q

which inhaled anesthetic causes hepatitis?

A

halothane

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2
Q

two inhaled anesthetics that cause renal toxicity

A

sevoflurane, enflurane

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3
Q

most IV anesthetics act how?

A

on GABA receptors

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4
Q

how to reverse midazolam

A

flumazenil

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5
Q

two AEs of propofol

A

hypotension, anti-emetic

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6
Q

what does dexmedetomidine act on?

A

a2 adrenergics (agonist)

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7
Q

how are barbiturates and benzos adjuncts to anesthesia?

A

increase GABA receptor sensitivity/opening

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8
Q

how do local anesthetics work?

A

block voltage-gated Na channels

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9
Q

three local anesthetics that are the most potent + longest duration

A

bupivacaine, ropivacaine, tetracaine

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10
Q

which local anesthetic is surface use only bc poor solubility in water?

A

benzocaine

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11
Q

what does high blood:gas partition coefficient mean?

A

quicker anesthesia onset

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12
Q

NMJ blockers: non-depolarizing vs depolarizing block: which is succinycholine?

A

succ = depolarizing blockage

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13
Q

how to reverse non-depol NMJ blockers?

A

cholinesterase inhibitors

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14
Q

three NMJ blockers that are long-acting

A

doxacurium, pancuronium, pipercuronium

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15
Q

which spasmolytic is also an anxiolytic?

A

carisoprodol

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16
Q

two spasmolytics that arent centrally acting

A

dantrolene, botulinum toxin

17
Q

MOA of dantrolene and botulinum toxin

A
  1. Dantrolene: block Ca release from SR

2. Botulinum: cleave VAMP -> no Ach release

18
Q

MOA fo glatiramer acetate

A

similar to myelin basic proteim -> activates T cell suppressors

19
Q

MOA of INF-B for MS

A

binds VLA-4 on T cells -> cant bind BBB to enter brain

20
Q

MOA of Mitoxantrone for MS

A

intercalates into DNA

21
Q

translocation seen in Ewing Sarcoma

A

t(11;12)

22
Q

only osteoporosis drug that increases bone formation

A

teriparatide

23
Q

raloxifene MOA

A

SERM: selective estrogen receptor modulator

24
Q

MOA of denosumab for osteoporosis

A

RANKL inhibitor

25
Q

probenecid MOA for gout

A

blocks urate reabsorption

26
Q

major drug for osteoporosis in men

A

bisphosphonates

27
Q

DMARD that is notably oral administration

A

Tofacitinib

28
Q

order of best to worse csDMARDs in low dz activity pts

A
  1. HCQ
  2. SSL
  3. MTX
  4. Leflunomide
29
Q

three AchEs that treat Myasthenia gravis

A

ambenonium, neostigmine, pyridostigmine

30
Q

pralidoxime

A

reverses weakness and sensory loss from organophosphates by regenerating AchE

2: NMSP Exam 2 (18 decks)

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