22: Peripheral Nerve Disorders

Question 1

onion bulbs on histo

Answer 1

concentric layers of schwann cytoplasm and redundant BM surrounding thinly myelinated axons

Question 2

major peripheral neuropathy that involves autonomic nerves too

Answer 2

diabetic neuropathy

Question 3

what do thin unmyelinated vs thick myelinated nerve fibers tend to carry?

Answer 3

1. thin unmyelinated: autonomics, pain, temp

2. large with thick myelin: light touch, motor signals

Question 4

mononeuritis multiplex

Answer 4

several nerves damaged in a haphazard fashion

Question 5

common cause of mononeuritis multiplex

Answer 5

vasculitis

Question 6

polyradiculoneuropathy

Answer 6

peripheral nerve & nerve roots affected -> diffuse symmetric in prox and distal parts of body

Question 7

POEMS

Answer 7

polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (occurs in malignancy)

Question 8

traumatic neuroma

Answer 8

nerve damaged -> regenerates slowly -> axons grow in misalignment and form small bundles of axons in random orientation