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Block 1 Week 2 > Extracellular Matrix Proteins > Flashcards

Extracellular Matrix Proteins Flashcards

1
Q

ECM proteins providing structural support

A

Collagen

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2
Q

ECM proteins providing elasticity

A

Elastin, fibrin

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3
Q

Proteins providing adhesion between structural matrix proteins

A

Laminin, fibronectin

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4
Q

ECM proteins providing mechanical support

A

Proteoglycans

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5
Q

ECM proteins providing anchoring and communication

A

Integrins

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6
Q

Where is elastin commonly found?

A

Forms elastic fibers in smooth muscle and lung

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7
Q

Elastin is synthesized as a ______ precursor

A

Tropoelastin

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8
Q

Elastin has alternating ______ and ______ domains

A

Hydrophilic and hydrophobic

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9
Q

Function of laminin

A

Cross links proteins in the basal laminae

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10
Q

Laminin structure

A

Heterotrimeric, triple helix, globular N extensions

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11
Q

Function of proteoglycans

A

Forms gel that provides mechanical support

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12
Q

Proteoglycans are extensively _______

A

Glycosylated

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13
Q

Carbs are usually attached to the core protein of proteoglycans via ____ or ______

A

Ser or Thr

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14
Q

Glycosaminoglycans consist of repeating ______

A

Disaccharides

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15
Q

Polysaccharide chains are called

A

Glycosaminoglycans

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16
Q

Integrins attach to adhesion proteins such as

A

Fibronectin

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17
Q

All integrins have ___ subunits

A

2

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18
Q

Integrins mediate _______ cell signaling

A

Two way

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19
Q

Over 90% of human collagen is types ______

A

I-III

20
Q

All collagens contain _____ polypeptide chains and have at least one ___ ______ ______

A

3, triple helix domain

21
Q

Type I collagen

A

Widely distributed, major component of tendon and bone

22
Q

Type II

A

Cartilage, cornea, vitreous fluid

23
Q

Type III

A

Loose CT, extensible tissues

24
Q

Collagen type I chain composition

A

[α1(I)]2 α2(I)

Skin and bone

25
Q

Collagen type II chain composition

A

α1(II)3

Cartilage

26
Q

Collagen type III chain composition

A

α1(III)3

Blood vessels

27
Q

Each collagen chain has _____ amino acids

A

1000

28
Q

In collagen chains, every third residue is ___

A

Gly

29
Q

Collagen contains about 20% ______ and _____\

A

Proline and hydroxyproline

30
Q

Each collagen chain forms a _____-like _____-handed helix

A

Proline, left

31
Q

Collagen chains are stabilized by

A

Steric repulsión of pyrrolidone rings

32
Q

Collagen helix is essentially a ________ structure

A

Tertiary

33
Q

Collagen helices are stabilized by

A

Interchain hydrogen bonds

34
Q

Vitamin C is required for what process?

A

Hydroxylation of proline and lysine residues in collagen chains

35
Q

Procollagen is the precursor for _____ collagens

A

Fibrillar

36
Q

How does procollagen become mature collagen?

A

Ends are cleaved to make tropocollagen

Tropocollagen is packed into collagen fibrils, which are then layered into mature collagen

37
Q

Sulfide bonds at the _-terminal assist with helix formation

A

C

38
Q

Collagen stability depends on cross links initiated by ____ _____

A

Lysyl oxidase

39
Q

Lysyl oxidase converts lysine or hydroxylysine into ______

A

Allysine

40
Q

Cross linking is an ENZYMATIC/NONENZYMATIC reaction between _____ and _____ groups

A

Non-enzymatic, lysyl and allysyl

41
Q

At what point during collagen synthesis is it secreted from the cell?

A

After the folding of the triple helix

42
Q

What type of collagen forms networks/mesh?

A

Type IV

43
Q

Scurvy is a disruption of what process?

A

Hydroxylation of proline and lysine, which in turn reduces interchain H bonding

44
Q

What clinical marker is indicative of collagen disorders?

A

Blue sclera

45
Q

Ehlers-Danlos manifests as

A

Loose skin and hyper flexible joints

46
Q

Substitutions of ____ in the α1(I) chain of collagen I can lead to what disease?

A

Glycine, osteogenesis imperfecta

Block 1 Week 2 (8 decks)

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