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Imported Study Blue JVD > export_jvd2015 321 bilgic feline scc > Flashcards

export_jvd2015 321 bilgic feline scc Flashcards

1
Q

Feline Oral squamous cell carcinoma: clinical manifestations and literature review

A

JVD2015 32(1), Bilgic O, Duda L, Sanchez MD, Lewis JR

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2
Q

most common oral tumor type in cat

A

SCC

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3
Q

Oral tumors account for what percentage in cats?

A

10% of all feline tumors, 90% malignant

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4
Q

Squamous cell carcinoma accounts for what percentage of oral tumors in cats

A

60-70%

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5
Q

most common location of SCC in cats

A

sublingual/lingual, maxilla, mandible, buccal mucosa, lip, caudal pharynx/tonsillar region

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6
Q

Metastatic rate of SCC in cats

A

35.7%

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7
Q

Where does it metastasize to?

A

mandibular lymph nodes and lungs

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8
Q

most cats succumb to the what effects of SCC?

A

local aggressive growth of primary tumor

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9
Q

Environmental factors contibuting to SCC in Cats

A
  1. environmental smoke (2X increased risk)
  2. flea collars (5.3x increased risk)
  3. canned food (3.6x increased risk)
  4. Canned tuna (4.7x increased risk)
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10
Q

Human papillomavirus has been implicated as risk factor for SCC in humans. IN cats…

A

more investigation warranted

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11
Q

Altered epidermal growth factor receptor (EGFR) may play a key role in feline oral SCC, true or false

A

True, 69% samples of feline oral SCC were reactive to EGFR

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12
Q

Cox-1

A

constitutive form, catalyzes synthesis of prostaglandins involved in homeostatic functions of GI, vasodilation of kidneys, synthesis of thromboxane

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13
Q

Cox - 2

A

inducible form, sites of inflammation. Proinflammatory cytokines, carcinogens, oncogenes, and mitogens can induce Cox-2 activiaton

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14
Q

cox-2 immunoreactivity in feline oral SCC

A

9% of samples positive in one study, 67% in another study, also observed in normal feline oral tissue (80%)

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15
Q

clinical signs of oral feline SCC

A

hyporexia, anorexia, lethargy, wt loss, decreased grooming, ptyalism, halitosis

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16
Q

Lingual/sublingual SCC in cats

A
  • common
  • frenulum/sublingual mucosa
  • quickly invades tongue
  • ulceration
  • sloughing of tongue
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17
Q

maxillary feline scc

A
  • invade bone
  • osteolysis
  • crater-like lesion
  • destruction of palantine process
  • caudal masses are ulcerative
  • inability to retropulse globe
18
Q

mandibular feline oral SCC

A
  • similar to maxillary lesions
  • mobile teeth
  • ulceration
  • periosteal proliferation
19
Q

Neoplasia that may mimic oral SCC

A

FSA, peripheral nerve sheath tumors, lymphoma, melanoma, OSA, Chond, adenocarcinoma, granular cell tumor, HSA, MCT, Plasma cell tumor, ectopic thyroid tissue

20
Q

What percentage of change in mineral content is needed before bone loss is appreciated on radiographs?

A

30 - 50 %

21
Q

What type of imaging modality is best for diagnosing oral SCC?

A

FDG-PET, or FDG-CT, Fluorodeoxyglucose positron emission tomography

22
Q

How should you assess tumor staging in feline oral scc?

A

regional lymph node aspirates, three view thoracic rads, hypercalcemia

23
Q

Recurrence rates of surgically treated feline oral scc

A

38% in one study of rostral mandible, another study had 80% recurrence, within 5 - 12 mo of surgery

24
Q

Median STT in cats with oral SCC, treated with surgery

A

< 6 months

25
Q

Median STT with cats treated with surgery and radiation

A

14months

26
Q

How do cats do with a mandibulectomy?

A

not well, function is affected, 12% unable to eat for up to 813 days

27
Q

complications of mandibulectomy of SCC in cats

A

mandibular drift, decreased prehension, ptyalism, tongue protrusion, decreased ability to groom

28
Q

Curative intent radiation treatment for feline oral SCC

A
  • many sml doses for 5 days each week for several weeks

- 2 doses per day or try 7 days per week

29
Q

Palliative radiation treatment for oral SCC in cats

A

-few large, weekly doses of radiation, hypofractionation

30
Q

What was the median STT in cats with partial response to radiation tx?

A

60 days

31
Q

what was the median STT in cats with complete response to XRT?

A

298 days

32
Q

What is the median STT in all cats with SCC treated with XRT

A

86 days

33
Q

Study looking at hypofractionization treatment in cats with oral scc and melanoma

A

median ST was 60 days and did not result in palliation

34
Q

does chemotherapy work in oral SCC in cats?

A

not as a solo treatment, efficacy poor,

35
Q

What treatment has improved stt in cats with oral SCC

A

curative intent surgery plus radiation tx, combination treatments work best

36
Q

What chemotherapy radiation combo improved STT

A

11 cats, concurrent xrt with chemo: mitoxantrone, 10 - 15 fx over 3 weeks, 8 cats went into remission for median time of 170 days

37
Q

Can Cox-2 inhibitors or NSAIDs help cats with oral SCC?

A

maybe beneficial, but COX-2 expression in feline oral SCC is less than in human and canine oral SCC.

38
Q

Palliative treatments

A

analgesia, nutritional supplements, infection control, opiods,

39
Q

dose of buprenorphine

A

0.02 mg/kg recommended

40
Q

Tramadol

A

synthetic aminocyclohexanol opioid analgesic acting on neurotransmission of noradrenaline and seratonin, dosing is lower, and longer interval than dogs

41
Q

Meloxicam dose

A

Cox-2 inhibitor, 0.1 mg/cat or 0.025 mg/kg either twice weekly or EOD.

Imported Study Blue JVD (17 decks)

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