export_jvd 2010 winter abs 249 materialssugawara in vivo charac of premixed cap cements implanted in sq tissues perio defects

Question 1

JVD 2010 Winter Abs Materials
In vivo Characteristicsof premix calcium Phosphate Cements when implanted in subcutaneous tissues and perio bone defects: Sugawara A, Fujikawa k. Hirayama S, et al.

Answer 1

J Res Natl Inst Stand Technol 2010 Jul;115(4):277-90

Question 2

2. What are characteristics of premixed calcium phosphate cements?

Answer 2

• longer hardening times and lower strength than conventional CPC
• the material hardens only after being delivered to a wet environment
• material forms hydroxyapatite as the only product.

Question 3

3. Goals of study:

Answer 3

• Study 1: put the paste SQ in rats and look for reaction
• Study 2: use 3 different premix ratios and see how the Pre-CPC pastes affected healing in created perio bony defects in beagles

Question 4

4. Results Study 1:

Answer 4

4 weeks after placement SQ, all the implanted materials showed slight or negligible inflammatory reactions in the tissues in contact with the CPC

Question 5

5. Study 2: M&M

Answer 5

• 3 different pastes were made up, with different powder to liquid masses and different chemical compositions

Question 6

6. Study 2: What happened with Pre-CPC-1 paste at 1 and 6 months?

Answer 6

1 month: partially replaced by bone

6 mon: converted to bone

Question 7

7. Study 2: What happened with Pre-CPC-2 paste at 1 and 6 months?

Answer 7

1 month: perio pockets completely covered by bone, partially replaced by trabecular bone

6 months: completely replaced by bone

Question 8

8. Conclusions:

Answer 8

• Pre-CPC 2 resorbed and was replaced by bone more rapidly than Pre-CPC 1 in periodontal defects.
• both pastes were very osteoconductive