Experiments for LTP 1

Question 1

LTP in SC

Answer 1

Stimulating electrode in SC and recording electrode on CA1

Many weak stimulation=always same response

Strong stimulation= very high response

back to weak stim= bigger response than at frist WS

Question 2

Early LTP in SC

Answer 2

1 train at 100HZ

Lasts 2 or 3h

Question 3

Late phase LTP

Answer 3

4 trains at 100Hz

Lasts 24h

Question 4

Role of NMDA in LTP

Answer 4

APV is an NMDA antagonist

if given before train of stimuation = no LTP

If given after stimualtion = LTP

• NMDA is necessay for induction of LTP, not maintenance