Experiments for Hormones 1

Question 1

Estrogen and ACh

Answer 1

Rats ovariectomized: 50% got estrogen back and 50% nothing

• The ones who got estrogen back showed a higher release of Ach one their hippo

Question 2

Number of dendritic spines and estrogen cycle

Answer 2

Prestrus = high estrogen

Diestrus = medium

Estrus = low estrogen

• more dendritic spines in CA1 when low estrogen = estrus
  
  • ​more NMDAR at the same time and enhaced LTP

Question 3

Estrogen ans radial maze

Answer 3

Food in 8 arms. Error = re entry in one arm after eaing

Ovaries removed and capsule with powder estrogen / choleserol

• capsule with estrogen = better spatial memory

Question 4

Estrogen and WM

Answer 4

Place training (reference memory)

4 groups: complex env / isolated env - intact ovaries / ovarectomized

• dumb group = isolted env + INTACT OVARIES
• complex env = very powerful

Question 5

Estrogen - Working and Reference memory

Answer 5

Only 4 arms have food (reference memory)

Once you ate the food, no need to go back (working memory)

All ovarectomized, half got estroge back

• estrogen = better working memory
• no effect on referecne memory

Question 6

Estrogen - Hippo - Striatum

Answer 6

Cross maze task - aquisition. All OVECT w/ 50% got E

• better at place learning
• worse at response learning

Question 7

Estrogen - WM - Ping pong ball

Answer 7

Platform is behind a black ping pong ball. Everyday le platform is moved.

Either they use the ping pong ball to find the platform, or spatial cues

• all learning
• trial 1: cholesterol does better, using the ping pong ball
• trial 4: estrogen does better, using cognitive map

Question 8

Androgenes and Radial arm maze

Answer 8

Working memory

• castrated rodents show impairment in spatial memory

Question 9

Androgenes and WM

Answer 9

Castration decrease performance

Testosterone treatment with castration = compensate and gets better