Experiments for Hormones 2

Question 1

Cycle and spatial memory performance

Answer 1

When levels are high, women do better than when levels are low.

Two groups of women: one on estrogen replacment (so level constant° and one on natural cycling.

Question 2

Women on hormone therapy have better cognitive abilities when on hormone therapy?

Answer 2

Many but not all studies said yes.

Question 3

Women’s Health Intiative Memory Study - Results

Answer 3

Large double blind placebo control (standard).

Looking across the board, and one arm looking at memory.

Saw that estrogen increase risk of stroke.

Question 4

Women’s Health Intiative Memory Study - Reconcile

Answer 4

• Conjugated equine estrogen : not estradiol!! So difference from what’s used in basic science.
• They used really quick survey: may be cognitive assessment not appropriate.
• Cohort: They chose women on their 70s who never had hormone therapy before.

Question 5

Support for the critical window

Answer 5

• Ovarectomie Ch for 5month and then Ch again (Ch/Ch)
• Ovarectomie - E/E
• Keep their ovaries and then E : Intact/E
• Ch/E.
  
  • The ones who got E after ovarectomy = better results
  • E/E and Intact/E
• Decrease in expression of ChAT