Exocrine Pancreas

Question 1

Dog vs cat pancreatitis

Answer 1

• dog: acute, vomit/lethargy, abdominal pain, dietary indiscretion, shock, dehydration, large bowel diarrhea
• cat: chronic, lethargy, anorexia, weight loss, some diarrhea or icterus or fever, not due to dietary indiscretion-idiopathic, non suppurative most common

Question 2

What mechanism prevent intrapancreatic enzyme activation.

Pancreatic pathogenesis

Answer 2

Inactive forms, infra cellular compartmentalization, enzyme inhibitors.
Etiologic factors—activation of pancreatic enzymes in pancreas—auto digestion—necrosis and inflammation—trypsin activates other proteins—systemic effects (shock, dic, edema)

Question 3

Triaditis

Answer 3

Cholangitis, ibd, pancreatitis

Question 4

Epi-scenario, lesion, pathophysiology. Does it happened in cats?

Answer 4

• gsd, weight loss but good appetite, small bowel greasy stool, no improvement after food changes, really wasting
• cats: chronic pancreatitis is the most common cause of epi, pancreas replaced by fibrous tissue, may have concurrent diabetes