Excitatory and Inhibitory Neurotransmission

Question 1

Sodium agonists cause excitation of a cell and potassium agonists cause inhibition of a cell. True/false?

Answer 1

True

Question 2

What are the four morphological regions of a neurone?

Answer 2

Soma
Dendrites
Axon
Synapse

Question 3

What are the two types of receptors for a neurotransmitter?

Answer 3

Ionotropic

Metabotropic

Question 4

In ionotropic receptors, the ion binds directly/indirectly

Answer 4

Directly

Question 5

GABA, glycine and ACh receptors are tetramers/pentamers

Answer 5

Pentamers

Question 6

Which neurotransmitter’s receptor is a tetramer channel?

Answer 6

Glutamate

Question 7

What is the major excitatory neurotransmitter?

Answer 7

Glutamatw

e

Question 8

When glutamate binds to its channel it allows the flow of cations/anions

Answer 8

Cations (Na/Ca/K)

Question 9

Non-NMDA ionotropic receptors mediate fast/slow excitatory synaptic transmission

Answer 9

Fast

Question 10

NMDA glutamate receptors have a high permeability to which ion?

Answer 10

Calcium

Question 11

What is the main inhibitory neurotransmitter?

Answer 11

GABA

Question 12

What two types of receptors does GABA act on?

Answer 12

Ionotropic GABA(a)
Metabotropic GABA(b)

Question 13

GABA(a) operates a K channel while GABA(b) activates a Cl channel. True/false?

Answer 13

False - GABA(a) = Cl and GABA(b) = K

Question 14

How do metabotropic receptors cause decreased neurotransmission?

Answer 14

By stimulating calcium channels or inhibiting potassium channels

Question 15

A depolarising change in change in membrane potential caused by excitatory neurotransmission is called what?

Answer 15

EPSP (excitatory postsynaptic potential)

Question 16

What is inhibitory postsynaptic potential?

Answer 16

When an inhibitory neurotransmitter causes a negative change in resting membrane potential

Question 17

G

Glutamate causes an EPSP while GABA causes an IPSP. True/false?

Answer 17

True