Exchange and the Lymphatic System Flashcards
How are capillaries specialised for exchange
Lots of them
Thin walled - diffusion barrier
Small diameter - large area:volume ratio
Continuous capillaries
Have no clefts or pores or only clefts
Fenestrated capillaries
Have clefts and pores
Discontinuous capillaries
Clefts and massive pores
By what methods to capillaries exchange material
Diffusion and carrier-mediated transport (blood-brain barrier)
Diffusion in capillaries
Self-regulating
Non-saturable
Non-polar substances across membrane
Polar substances through clefts/channels
Bulk-flow
Mass exchange of fluid
Effect of hydrostatic pressure in capillaries
Pushes fluid through the leaky capillaries, building up an osmotic (oncotic) pressure
Effect of osmotic (oncotic) pressure in capillaries
Draws fluid back into capillaries
Starlings forces
Balance of hydrostatic and osmotic pressures
Volume of fluid lost from capillaries per day
20L
Volume of fluid regained in capillaries per day
17L
Remaining fluid in capillaries
3L
The excess fluid is drained via
The lymphatic system
Oedema
Accumulation of excess fluid
Causes of oedema
Lymphatic obstruction
Raised central venous pressure (CVP)
Hypoproteimemia
Increased capillary permeability