Electrical Activity of the Heart Flashcards
Calcium is released from the
Sarcoplasmic reticulum
All cells of the heart are connected
Physically and electrically
What allows for physical connection of cells
Desmosomes
What allows for electrical connection of cells
Gap junction
Desmosomes and gap junctions together form
Intercalated discs
Cardiac muscle froms a
Functional syncytium
Action potential of cardiac muscle
250ms
Why can cardiac muscle not exhibit tetanic contraction
Due to long refractory period
Tetanus
Sustained contraction
What regulates the contraction of cardiac muscle
Calcium ions entry from outside the cell
Cardiac muscle can only contract in the presence of
Calcium ions
More calcium ions results in
Greater strength of contraction
Cells with unstable resting membrane potentials act as
Pacemakers
2 types of cardiac muscle
Non-pacemakers and pacemakers
Resting membrane potential of non-pacemaker cardiac muscle is maintained by
Potassium ions leaving the cell
Initial depolarisation in non-pacemaker cardiac muscle occurs by
Entry of sodium ions into cell
Plateau in non-pacemaker cardiac muscle is reached by
Entry of calcium ions via L-type voltage gated channels and potassium ions leaving the cell
Repolarisation in non-pacemaker cardiac muscle occurs by
Calcium ions leave the cell and potassium ions enter the cell
Action potential on pacemaker cardiac muscle occurs by
Entry of calcium ions inside the cell via L-type channels
Pacemaker potential/pre-potential occurs by
Gradual decrease (leave) of potassium ions inside cell, early increase (entry) of sodium ions and late increase (entry) of calcium ions via T-type channels
Autorhythmic
Heart has its own rhythm
How is the heart autorhythmic
By pacemakers always reaching threshold and contraction
Modulators of electrical activity
Sympathetic and parasympathetic systems Drugs Temperature Potassium ions Calcium ions
Effect of calcium ion channel blockers
Decrease force of contraction
Effect of cardiac glycosides
Increase force of contraction
Effect of increase of temperature
Increases electrical activity
Effect of hyperkalemia
Fibrillation and heart block
Heart block
Smaller electrical currents causing everything to work much slower than it should
Effect of hypokalemia
Fibrillation and heart block
Effect of hypercalcemia
Increased heart rate and force of contraction
Effect of hypocalcemia
Decreased heart rate and force of contraction
Sinoatrial node
Node containing the most pacemakers
Function of sinoatrial node
Causes atrial excitation and sets the pace for the rest of the heart (0.5m/s)
Location of sinoatrial node
Right atrium
Annulus fibrous
Fibrous tissue that separates atrium and ventricle
Atrioventricular node is also known as
Delay box
Function of atrioventricular node
Slows down excitation until the atrium is finished contracting (0.05m/s)
Bundle of His function
Conducts the electrical impulses from the atrioventricular node to the purkinje fibres
Function of purkinje fibres
Cause ventricle excitation (5m/s)
Bundle of His divides into
Purkinje fibres
How are large extracellular electrical waves formed
Summation of many small extracellular electrical potentials
Electrical activity can be recorded at the periphery as an
ECG (electrocardiodiagram)
P wave of ECG corresponds to
Atrial depolarisation
QRS complex corresponds to
Ventricular depolarisation
T wave corresponds to
Ventricular repolarisation
2 things that ECG can indicate
Disorders of conduction
Disorders of rhythm