Examples of Enzyme Inhibitors with Therapeutic Applications

Question 1

Xanthine oxidase

Treatment of gout

Answer 1

Allopurinol

Question 2

Cyclooxygenase

Antiinflammatory agent

Answer 2

Aspirin

Question 3

Thymidylate synthetase

Antineoplastic agent

Answer 3

5-Fluorouracil

Question 4

HMG-CoA reductase

Cholesterol-lowering agent

Answer 4

Lovastatin

Question 5

Monoamine oxidase

Antihypertensive agent

Answer 5

Pargyline

Question 6

Transpeptidase

Antibacterial agent

Answer 6

Penicillin

Question 7

● Gout is the accumulation of_____

● Uric acid came from the breakdown of_____.

● In order for the purine to become a uric acid it needs the help of_____

Answer 7

URIC ACID

PURINE

XANTHINE OXIDASE

Question 8

if we eat food that is rich in_____ our_____ will now convert it into ____for it to be urinated.

● Too much accumulation of uric acid will now be deposited into our joints and will lead to gout

Answer 8

purine

xanthine oxidase

uric acid

Question 9

In patients with gout, uric acid is avoided and the drug______ inhibits Xanthine oxidase thus uric acid production is LOWERED.

Answer 9

ALLOPURINOL