Exam II Practice Questions Flashcards
The toxic agent MOST likely to produce degeneration of peripheral neurons is
arsanilic acid
Deferoxamine is the chelating agent of choice for
iron
Enlarged yellow liver, enlarged friable and hemorrhagic kidneys, enlarged black spleen, and red wine-colored urine are lesions MOST likely associated with
chronic copper toxicosis
Reduced cytochrome oxidase in cattle can be used as a diagnostic test in toxicosis with
Molybdenum
Chronic diarrhea, depigmentation, emaciation and lameness in cattle suggest toxicosis with
Molybdenum
Clinical signs of subacute selenium toxicosis in pigs are generally similar to toxicosis with
Arsanilic acid
Swine consuming feed containing high (10 ppm) levels of selenium over several weeks are likely to show clinical signs that would be very similar to which disease?
Arsanilic acid toxicosis
Poisoning by ingestion of seleniferous plants can be seen in the following states EXCEPT:
a. South Dakota
b. North Dakota
c. Wyoming
d. Florida
e. Montana
Florida
Poisoning by ingestion of seleniferous plants can be seen in the following states EXCEPT:
a. South Dakota
b. North Dakota
c. Montana
d. Wyoming
e. New York
New York
Which of the following is NOT effective in the treatment or prevention of chronic selenium toxicosis?
a. the addition of copper to diet
b. the addition of organic arsenicals to the diet
c. intramuscular injection of BAL
d. Increasing the dietary level of sulfur-containing proteins
c. intramuscular injection of BAL
Inhibition of lipoic acid which results in inhibition of citric acid cycle is the mechanism of action of
trivalent arsenic
Which of the following metal toxicoses causes inhibition of the activity of several enzymes in heme synthesis?:
a. iron
b. zinc
c. inorganic arsenic
d. lead
Lead
Which of the following is LEAST likely a clinical sign of chronic copper toxicosis in sheep?:
a. GI signs
b. jaundice
c. hemoglobinuria
d. methemoglobinemia
e. hemolysis
a. GI signs
The presence of an odor of rotten garlic in a fresh carcass is suggestive of acute toxicosis with
Selenium
A dog showing gastrointestinal signs followed by a phase of apparent recovery, which deteriorates into multiorgan failure is MOST likely poisoned with oral
Iron
The metal toxicosis LEAST likely to cause signs of gastroenteritis is:
a. lead
b. zinc
c. inorganic arsenic
d. organic arsenic feed additives
e. iron
d. organic arsenic feed additives
* TREATS enteric (GI) diseases!*
Lameness, hoof abnormalities, emaciation, and loss of hair in cattle MOST likely suggest toxicosis with
chronic selenium
Methylene blue IV is the antidotal treatment for
Copper, Nitrate (and Nitrogen Oxide gases)
The MOST appropriate treatment for nitrate poisoning is
Methylene Blue IV
Clinical signs in cows suffering from milk fever (hypocalcemia) are MOST similar to poisoning with which of the following toxicants in sheep?:
a. fluoride
b. soluble oxalate
c. cyanide
d. nitrate
e. urea
Soluble oxalate
- fluoride – gasteroenteritis, hemorrhagic, CNS stimulation, death from respiratory and cardiac failure, bony exostoses, spontaneous fractures
b. soluble oxalate – colic, muscles twitching, rapid breathing, blood tinged froth around the mouth, similar to milk fever
c. cyanide – MM bright red and blood is cherry red,
d. nitrate – sudden death with no signs, abortion, seizures
e. urea - Restlessness. Aggression, Muscle tremors, Colic, Bloat, Usually NO diarrhea
Ingestion of plants that have been sprayed with the recommended levels of 2,4-D herbicides may cause poisoning in livestock MAINLY because:
a. recommended levels of 2,4-D herbicides usually cause poisoning in livestock
b. conversion of 2,4-D herbicides to more toxic metabolites
c. accumulation of toxic levels of soluble oxalates by the plant
d. accumulation of toxic levels of nitrate by the plant
e. direct inhibition of the satiety center resulting in increasing ingestion of toxic levels of the 2,4-D herbicide
accumulation of toxic levels of nitrate by the plant
Ingestion of kerosene is MOST likely to cause:
a. posterior paralysis
b. severe CNS depression
c. hemolysis and methemoglobinemia
d. severe aspiration pneumonia
e. bone abnormalities and osteoporosis
severe aspiration pneumonia
Chronic fluoride poisoning in cattle causes:
a. diarrhea, pale hair coat, lameness and hoof overgrowth
b. icterus, hemoglobinuria, and photosensitization
c. emaciation, hair loss, and lameness
d. rumen stasis, nephrosis, and constipation
e. lameness, exostoses, and excessive dental wear
lameness, exostoses, and excessive dental wear
The specimen of choice to confirm a diagnosis of chronic fluoride poisoning in a live animal is:
a. feed
b. water
c. urine
d. bone
e. GI contents
Bone
Soluble oxalate poisoning is often associated with which plant:
a. Jimsonweed (Datura stramonium)
b. Halogeton (Halogeton glomeratus)
c. milkweed (Asclepias carassavia)
d. castor bean (Ricinus communis)
Halogeton (Halogeton glomeratus)
A selenium indicator plant which is grown widely in the west is:
a. larkspur (Delphenium spp.)
b. greasewood (Sarcobatus vermiculatus)
c. prince’s plume (Stanlyea spp.)
d. halogeton (Halogeton spp.)
e. wild cherry (Prunus spp.)
Prince’s Plume (Stanleya spp.)
Dogs poisoned by ingesting large amount of chocolate will be expected to show which of the following clinical signs?
a. Posterior paralysis and constipation
b. CNS depression, skin rashes, and oliguria
c. bleeding, vomiting, dehydration and shock
d. convulsions, tremors, tachycardia, and urination
e. reddening of the skin, alopecia, and lameness
convulsions, tremors, tachycardia, and urination
Cyanide and hydrogen sulfide both:
a. are plant related toxicants
b. react with other metals to form black or dark colored compounds in the GI tract and may stain the tissues
c. cause sudden death mainly due to preventing tissue oxygen utilization
d. are free of irritant effects to mucous membranes
e. can cause tolerance in animlas to their characteristic odors
cause sudden death mainly due to preventing tissue oxygen utilization
Which of the following statements concerning hydrogen sulfide and cyanide is TRUE?
a. They are plant related toxicants
b. They react with metals to form black or dark colored compounds in the GI tract
c. They are free of irritant effect
d. Sodium nitrite IV is useful in their treatment
Sodium nitrite IV is useful in their treatment
The specimen of choice for nitrate poisoning in an animal that has been dead for several hours is
ocular fluid
Which of the following is LEAST effective in the treatment of poisoning by cyanogenic plants?
a. sodium nitrite IV
b. sodium thiosulfate IV
c. vinegar in cold water orally
d. activated charcoal orally
e. mineral oil orally
activated charcoal orally
A toxicant that causes very rapid death, has a characteristic odor (almonds), and causes bright red mucous membranes and cherry red blood is
a. carbon monoxide
b. hydrogen sulfide
c. nitrate
d. urea
e. cyanide
Cyanide
(Carbon monoxide also causes cherry red mm and blood, but it is odorless!)
Late clinical signs of ethylene glycol poisoning are PRIMARILY related to
a. CNS depression
b. cardiovascular depression
c. acute renal failure
d. hepatic failure
e. peripheral neurotoxicity
acute renal failure
Acute renal failure as a result of ethylene glycol toxicosis usually occurs how long after ingestion in the dog?
a. 1-6 hours after ingestion
b. 6-12 hours after ingestion
c. 12-24 hours after ingestion
d. 24-72 hours after ingestion
24-72 hours after ingestion
Which of the following serum parameters is LEAST likely to be elevated in urea toxicosis?
a. ammonia
b. blood urea nitrogen (BUN)
c. glucsose
d. pH
e. transaminases (ALT, AST)
pH
[rumen pH is increased (basic), but serum pH is decreased (acidic)]
Toxicity of a new chemical is 3 mg/kg to lambs. if lambs eat 6% of their body weight, what will be the concentration of this chemical in ppm in feed for a lamb weighing 11 pounds?
a. 1 ppm
b. 5 ppm
c. 15 ppm
d. 50 ppm
e. 500 ppm
50 ppm
11 lbs = 5 kg
3 mg x 5 kgs = 15 mgs (toxic dose)
6% of 5 kg = 0.3 kg (so you need 15 mgs in 0.3 kgs of feed to be toxic)
15 mg/ 0.3 kg = 50 mg/kg = 50 ppm
Remember: mg/kg = ppm!
You wish to prepare chlorhexidine disinfectant solution at 150 ppm. How much approximately do you need from chlorhexidine disinfectant solution 2% to add it to water to make 1 gallon of 150 ppm chlorhexidine solution?
a. 0.25 fluid ounce
b. 0.5 fluid ounce
c. 1 fluid ounce
d. 2 fluid ounces
e. 4 fluid ounces
1 fluid ounce
[Stock (ppm)x(vol)] / [Wanted (ppm)x(vol)] = 1
1% = 10,000 ppm. 1 gallon = 128 oz
20,000(vol)/150(128) = 1
20,000(vol)/19,200 = 1
20,000 (1.04 oz) /19,200 = 1
Fomepizole (4-methyl pyrazole) is recommended as an antidote for both ethylene glycol and propylene glycol poisonings in dogs.
a. True
b. False
FALSE
Fomepizole (4-methyl pyrazole) is used in the treatment of ethylene glycol in dogs and cats by inhibiting alcohol dehydrogenase and is most effective within 3 hours from ingestion of ethylene glycol.
a. True
b. False
FALSE
- Fomepizole (4-methyl pyrazole) is used as an antidote for ethylene glycol poisoning in dogs, but is not recommended in cats because of its toxicity.
a. True
b. False
FALSE