Exam 6 Review Flashcards
you do a CBC on a patient that presents for an annual wellness exam. the patient has a moderate lymphocytosis with 20k lymphocytes that appear small and mature on the blood smear. you submit peripheral blood for flow cytometry and the only abnormality is a high level in CD21. what is your interpretation of these results?
an increase in CD21 is suggestive of B cell chronic lymphocytic leukemia
what are the best differentials for a persistent lymphocytosis in a dog?
- thymoma
- hypoadrenocorticism (addison’s)
- leukemia
a dog presents for peripheral lymphadenopathy. cytology is diagnostic for lymphoma. the CBC and biochem profiles are normal. what is the next best test to characterize the lymphoma and determine prognosis?
flow cytometry on a lymph node aspirate
you do flow cytometry on a Golden that presents for lymphocytosis and peripheral lymphadenopathy. Flow reveals a homogenous population of T cells that have lost expression of the pan-leukocyte antigen CD45. what type of tumor does this patient have and what is the prognosis?
T zone lymphoma- good prognosis!
describe epithelial cells on a smear
clusters with distinct cell junctions
a PARR assay reveals a clonal T cell receptor rearrangement and polyclonal Ig rearrangements in a 10 year old cat that presents for respiratory signs and fluid in the chest. what is the most likely diagnosis?
T cell lymphoma/leukemia
what is the best diagnostic test for a leukocyte adhesion deficiency?
flow cytometry with antibodies that detect CD18 protein
you do an aspirate on a suspicious mammary tumor. a portion of the mass is fluid-filled. what is the most appropriate next step?
aspirate the solid mass surrounding the fluid-filled portion of the mass
what sampling technique is best for mucosal cytology (ex vaginal cytology)?
swab/roll technique
what cytologic findings would support your hypothesis that an enlarged mandibular lymph nodes are reactive?
many small, mature lymphocytes; moderate numbers of plasma cells
the main purpose of Kohler illumination is to set the _______ at the correct position
condensor knob
what technique is most likely to result in a diagnostically useful sample?
aspirate multiple areas of the mass to ensure a representative sample
