Exam 5 - Infectious Disease Pathophysiology Flashcards

1
Q

T/F: Meropenem does not cover MRSA, enterococcus, or fungus.

A

TRUE

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2
Q

What are the four types of BETA-LACTAMS?

A

1) PCN
2) Cephalosporins
3) Carbapanems
4) Monobactam

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3
Q

The four types of beta-lactams include: ____, _____, _____, and _____.

A

The four types of beta-lactams include: PENICILLINS, CEPHALOSPORINS, CARBAPENEMS, and MONOBACTAM.

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4
Q

Name the four penicillin drugs.

A

1) PCN G
2) PCN VK
3) Procaine PCN
4) Benzathine PCN

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5
Q

Name the three penicillin-ase resistant penicillins.

A

1) Nafcillin
2) Oxacillin
3) Dicloxacillin

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6
Q

Name the 4 amino penicillins.

A

1) Ampicillin
2) Amoxicillin
3) Ampicillin-sulbactam = UNASYN
4) Amoxicillin-clavulanic acid = AUGMENTIN

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7
Q

What is the generic name for Unasyn?

A

Amoxicillin-sulbactam

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8
Q

What is the brand name for Amoxicillin-sulbactam?

A

Unasyn

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9
Q

What is the generic name for Augmentin?

A

Amoxicillin-clavulanic acid

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10
Q

What is the brand name for Amoxicillin-clavulanic acid?

A

Augmentin

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11
Q

Name the extended spectrum PCN.

A

Piperacillin-tazobactam = ZOSYN

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12
Q

How is Piperacillin-tazobactam classified?

A

It is an extended-spectrum pcn

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13
Q

What is the generic name for Zosyn?

A

Piperacillin-tazobactam

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14
Q

What is the brand name for Piperacillin-tazobactam?

A

Zosyn

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15
Q

Name the two Oxazolidinone drugs.

A

1) Linezolid = Zyvox

2) Tedazolid = Sivextro

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16
Q

How are Linezolid and Tedazolid classified?

A

They are both Oxazolidinone drugs

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17
Q

What is the brand name for Linezolid?

A

Zyvox

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18
Q

What is the brand name for Tedazolid?

A

Sivextro

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19
Q

What is the generic name for Sivextro?

A

Tedazolid

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20
Q

What is the generic name for Zyvox?

A

Linezolid

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21
Q

When are the penicillin-ase resistant penicillins used?

A

For MSSA

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22
Q

What are the penicillin-ase resistant penicillin drugs that are used for MSSA?

A

Nafcillin
Oxacillin
Dicloxacillin

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23
Q

Why are penicillin drugs used so often?

A

They are narrow spectrum drugs

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24
Q

What are the uses for Benzathine and Procaine?

A
Syphillis
Strep throat (IM injection)
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25
Q

Name the classes of drugs that fall under Beta-Lactam drugs.

A
  • PCN
  • Cephalosporins
  • Carabapenems
  • Monobactam
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26
Q

What do Unasyn (Ampicillin-sulbactam), Augmentin (Amoxicillin-clavulanic acid), and Zosyn (Piperacillin-tazobactam) have in common?

A

They have beta-lactamase inhibitors with them

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27
Q

Name the two 1st generation cephalosporins.

A

1) Cefazolin (Ancef)

2) Cephalexin (Keflex)

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28
Q

How are Cefazolin and Cephalexin classified?

A

1st generation cephalosporin

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29
Q

What is the brand name for Cefazolin?

A

Ancef

30
Q

What is the generic name for Ancef?

A

Cefazolin

31
Q

What class of drug is Cefazolin (Ancef)?

A

1st generation cephalosporin

32
Q

What is the generic name for Keflex?

A

Cephalexin

33
Q

What is the brand name for Cephalexin?

A

Keflex

34
Q

What class of drugs are Ancef and Keflex?

A

1st generation cephalosporins

35
Q

Name the five 2nd generation cephalosporins.

A

1) Cefuroxime = Ceftin
2) Cefoxitin = Mefoxitin
3) Cefotetan
4) Cefaclor = Ceclor
5) Cefprozil = Cefzil

36
Q

What is the generic name for Ceftin?

A

Cefuroxime

37
Q

What is the generic name for Mefoxitin?

A

Cefoxitin

38
Q

What is the generic name for Ceclor?

A

Cefaclor

39
Q

What is the generic name for Cefzil?

A

Cefprozil

40
Q

What is the brand name for Cefprozil?

A

Cefzil

41
Q

What is the generic name for Ceclor?

A

Cefaclor

42
Q

What is the generic name for Mefoxitin?

A

Cefoxitin

43
Q

What is the generic name for Ceftin?

A

Cefuroxime

44
Q

What are the 2nd generation cephalosporins?

A

Cef x 5 (Cef-o x 2, Cef-a, Cef-p, Cef-u)

1) Cefuroxime
2) Cefoxitin
3) Cefotetan
4) Cefaclor
5) Cefprozil

45
Q

What class of drug is Cefepime (Maxipime)?

A

4th generation cephalosporin

46
Q

What class of drug is Ceftaroline (Teflaro)?

A

5th generation cephalosporin

47
Q

What class of drug is Clindamycin (Cleocin)?

A

Lincomycin

48
Q

Name the ten 3rd generation cephalosporins.

A

1) Ceftriaxone = Rocephin
2) Cefotaxime = Claforan
3) Ceftazidime = Fortax
4) Ceftazidime-avibactam = Avycaz
5) Cefpodoxime = Vantin
6) Ceftibuten = Cedax
7) Cefixime = Suprax
8) Cefditoren = Spectracef
9) Cefdinir = Omnicef
10) Ceftolozane-tazobactam = Zerbaxa

49
Q

What is the generic of the following 3rd gen cephalosporin: Rocephin?

A

Ceftriaxone

50
Q

What is the generic of the following 3rd gen ceph: Claforan?

A

Cefotaxime

51
Q

What is the generic of the following 3rd gen ceph: Fortax?

A

Ceftazidime

52
Q

What is the generic of Rocephin?

A

Ceftriaxone

53
Q

Name the 1st gen ceph drugs (FA, PHA).

A

1) Cefazolin (Ancef)

2) Cephalexin (Keflex)

54
Q

Name the 2nd Gen Ceph drugs (1 ME, TIN, TAN, CLOR, ZIL).

A

1) Cefuroxime
2) Cefoxitin
3) Cefotetan
4) Cefaclor
5) Cefprozil

55
Q

What type of Gram stain are Staphylococci, Coagulase-negative staphylococcus, and streptococcus?

A

Gram POSITIVE

56
Q

What type of Gram stain is E. coli?

A

Gram NEGATIVE

57
Q

What type of Gram stain is Klebseilla, Enterobacter, and Citrobacter spp.?

A

Gram NEGATIVE

58
Q

Zosyn, Cefepime, and Meropenem all cover what type of bacteria (+ or -)?

A

Gram NEGATIVE

59
Q

What does mecA convert?

A

MSSA into MRSA

60
Q

What does mecA do?

A

Converts MSSA into MRSA

61
Q

A mecA positive organism is what type of organism?

A

MRSA

62
Q

T/F: Not all carbapenems cover pseudomonas.

A

TRUE

- Ertapenem does not cover pseudomonas

63
Q

_____ makes enterococcus vancomycin-resistant enterococci (VRE).

A

vanA makes enterococcus vancomycin-resistant enterococci (VRE).

64
Q

____ makes E. coli, K. pneumoniae, Proteus spp. resistant to 3rd gen CPN.

A

ESBL makes E. coli, K. pneumoiae, Proteus spp. resistant to 3rd gen CPN.

65
Q

What is the drug of choice for ESBL?

A

Carbapenems - Ertapenem since you do not need pseudomonas coverage

66
Q

Brand name of Ertapenem = ?

A

Invanz

67
Q

____ makes K. pneumoniae resistant to carbapenems (Carbapenemase).

A

KPC makes K. pneumoniae resistant to carbapenems (Carbapenemase).

68
Q

What is the drug of choice for KPC?

A

Ceftazidime/Avibactam

Cefiderocol

69
Q

Drug of choice for MSSA?

A

Nafcillin
Oxacillin
Cefazolin

70
Q

Drug of choice for Rocky Mountain Spotted Fever?

A

Doxycycline

71
Q

Drug of choice for B. fragilis?

A

Metronidazole - for ANAEROBES

72
Q

What do you give in a pregnant patient with Group B strep?

A

PCN G