Exam 5 - HIV Flashcards

1
Q

how is HIV transmitted

A

direct contact with infected blood, blood product, and/or bodily fluid

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2
Q

which 3 cell types are primarily infected

A

helper T
CD4
macrophages

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3
Q

where is CD4 located

A

antigen that sits on the surface of T cell

primary receptor for taking on the HIV virus

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4
Q

initial infection s/sx can occur when

A

within days to weeks

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5
Q

initial infection s/sx

A

fever
fatigue
sore throat
arthralgia
myalgia
N/V/D
HA
rash

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6
Q

s/sx with disease progression

A

malaise, fatigue
fever, night sweat
invol. weight loss
anemia
thrombocytopenia
leukopenia
mouth ulcers, thrush
pharyngitis
genital ulcers
hepatomegaly

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7
Q

normal CD4 count

A

> 1000

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8
Q

HIV CD4 count

A

< 500

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9
Q

CD4 count < 200 indicates ___

A

AIDS

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10
Q

can a person with an intact immune system have pneumocystis carinni PNA

A

No

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11
Q

pneumocystis carinii PNA is caused by a common

A

fungus

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12
Q

s/sx of pneumocystis carinii PNA

A

fever
cough
dyspnea, tachypnea
tachycardia
mild CP
sputum production

may lead to cyanosis and respiratory distress

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13
Q

leading cause of death among those with HIV

A

TB

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14
Q

s/sx of TB

A

productive cough
fatigue
weight loss
lymphadenopathy

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15
Q

this is often the first indication of progression to AIDS

A

candidiasis

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16
Q

candidiasis can cause these

A

oral thrush
esophagitis
vaginal candidiasis

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17
Q

when does mycobacterium avium complex occur

A

CD4 count is < 50

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18
Q

this is the major cause of wasting syndrome

A

mycobacterium avium complex

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19
Q

most common sites for Kaposi’s sarcoma

A

face + ears

common viscera sites: GI tract + lungs

20
Q

average survival rate after Kaposi’s sarcoma dx

21
Q

which 2 types of lymphomas are common with HIV

A

Hodgkin’s
lymphoma of the brain

22
Q

common s/sx of lymphomas in HIV pts

A

HA
change in mental status

23
Q

will a women with cervical can who has AIDS likely die from the cancer or AIDS

24
Q

HIV associated nephropathy leads to these changes

A

proteinuria
azotemia
normal to enlarged kidneys
glomerular lesions

25
what is the leading cause of ESRD in HIV pts
HIV associated nephropathy
26
what 2 tests need to be performed together for HIV dx
ELISA Western blot they detect HIV antibodies
27
women with HIV should have this performed every 6 months
pap smear to screen for cervical cancer
28
what is the 3 goals of HIV drug therapy
suppress the infection decrease symptoms prolong life
29
4 drug classes used for HIV management
Neucleoside reverse transcriptase inhibitors (NRTIs) nonnucleoside reverse transcriptase inhibitors (NNRTIs) Protease inhibitors (PIs) Integrase inhibitors (INSTIs)
30
how to know HIV drug therapy is effective
monitor viral load and CD4 count
31
is drug therapy single or multi-drug therapy
multi-drug therapy
32
Nucleoside reverse transcriptase inhibitors (NRTIs) end in what
-ine
33
nonnucleoside reverse transcriptase inhibitors have what in their name
-vir-
34
Protease inhibitors (PIs) end in what
-navir
35
what is protease
an enzyme needed for viral assembly and maturation
36
inTEGRAse strand transfer inhibitors (INSTIs) end in what
-telgravir
37
why is tenofovir (Truvada) administered for
reduce risk fo HIV for those at high risk for contraction
38
tenofovir (Truvada) education
must be used with a condom
39
all pts with HIV should receive which vaccines
Pneeumococcal flu Hep A and B HiB
40
caution giving which vaccines to those with HIV
live vaccines MMR varicella rotavirus intranasal flu
41
what abx is used with CD4 count falls less than 200
trimethoprim-sulfamethoxazole (Bactrim)
42
when is isoniazid administered
positive PPD, negative CXR
43
how long can HIV live on the surface
7-10 days
44
should you recap needles/syringes
No
45
what should be used to clean blood + body fluids
germicidal solution 1:10 concentration of household bleach is okay
46
PPE for HIV with bodily fluid contact
gloves mask eye shield gown