Exam 5 (final) - Svensson cannabis Flashcards

1
Q

hemp contains _____% or less THC

A

0.3%

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2
Q

marijuana contains _____% THC

A

15-20

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3
Q

synthetic marijuana contains analogs of THC that bind to _____ and ____ receptors as _____ agonists, unlike THC in non-synthetic marijuana, which is a ______ agonist at the same receptors

A

CB1, CB2, full, partial

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4
Q

T/F: cannabidiol binds to CB1 and CB2 receptors

A

F

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5
Q

dronabinol (Marinol) uses

A

-AIDS associated anorexia
-refractory chemotherapy-related N and V
-appetite stimulant in cancer pts

comes as synthetic delta-9 THC in sesame oil

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6
Q

nabilone (Casamet) uses

A

chemotherapy related N and V

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7
Q

cannabidiol (Epidolex) uses

A

2 rare seizure disorders:
Dravet syndrome
Lennox-Gastaut syndrome

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8
Q

what is cannabinoid hyperemesis syndrome

A

prolonged, excessive cannabinoid ingestion that leads to ab pain and cyclic vomiting
-often pts will take hot baths/showers to relieve symptoms

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9
Q

primary euphoric agent in cannabis

A

delta-9 THC

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10
Q

4 main components of Endocannabinoid System (ECS) in CNS

A

-receptors (CB1 and CB2)
-ligands (anandamide and 2-AG)
-transporter (endocannabinoid membrane transporter-EMT)
-enzymes (FAAH, MAGL, DAG)

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11
Q

CB1 is predominantly expressed in ____ (brain or periphery)

A

brain

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12
Q

CB2 is predominantly expressed in ____ (brain or periphery)

A

periphery

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13
Q

CB1 receptor expression is ______ in respiratory centers of brainstem

A

low

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14
Q

T/F: CBD products are regulated by FDA

A

F
-and they may contain highly variable amounts of THC and CBD

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15
Q

THC content in cannabis samples seized by DEA has markedly ______ over the past ~25 years

A

increased

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16
Q

cannabis use disorder requires __ or more of the criteria

A

2

17
Q

what percent of cannabis users will develop CUD

A

10%

18
Q

most commonly seen association between cannabis and a mental health disorder is what disorder?

A

schizophrenia

19
Q

two risk factors for increasing your risk of developing schizophrenia

A

-age of use (younger you start using, more likely you are to get it)
-more potent product (more potent, more likely you are to get it)

20
Q

treatment of cannabinoid hyperemesis syndrome

A

-cannabis cessation
-benzos (antianxiety)
-haloperidol (antinausea)
-capsaicin cream (on abs)