Exam 5 (final) - Svensson cannabis

Question 1

hemp contains _____% or less THC

Answer 1

0.3%

Question 2

marijuana contains _____% THC

Answer 2

15-20

Question 3

synthetic marijuana contains analogs of THC that bind to _____ and ____ receptors as _____ agonists, unlike THC in non-synthetic marijuana, which is a ______ agonist at the same receptors

Answer 3

CB1, CB2, full, partial

Question 4

T/F: cannabidiol binds to CB1 and CB2 receptors

Answer 4

F

Question 5

dronabinol (Marinol) uses

Answer 5

-AIDS associated anorexia
-refractory chemotherapy-related N and V
-appetite stimulant in cancer pts

comes as synthetic delta-9 THC in sesame oil

Question 6

nabilone (Casamet) uses

Answer 6

chemotherapy related N and V

Question 7

cannabidiol (Epidolex) uses

Answer 7

2 rare seizure disorders:
Dravet syndrome
Lennox-Gastaut syndrome

Question 8

what is cannabinoid hyperemesis syndrome

Answer 8

prolonged, excessive cannabinoid ingestion that leads to ab pain and cyclic vomiting
-often pts will take hot baths/showers to relieve symptoms

Question 9

primary euphoric agent in cannabis

Answer 9

delta-9 THC

Question 10

4 main components of Endocannabinoid System (ECS) in CNS

Answer 10

-receptors (CB1 and CB2)
-ligands (anandamide and 2-AG)
-transporter (endocannabinoid membrane transporter-EMT)
-enzymes (FAAH, MAGL, DAG)

Question 11

CB1 is predominantly expressed in ____ (brain or periphery)

Answer 11

brain

Question 12

CB2 is predominantly expressed in ____ (brain or periphery)

Answer 12

periphery

Question 13

CB1 receptor expression is ______ in respiratory centers of brainstem

Answer 13

low

Question 14

T/F: CBD products are regulated by FDA

Answer 14

F
-and they may contain highly variable amounts of THC and CBD

Question 15

THC content in cannabis samples seized by DEA has markedly ______ over the past ~25 years

Answer 15

increased

Question 16

cannabis use disorder requires __ or more of the criteria

Answer 16

2

Question 17

what percent of cannabis users will develop CUD

Answer 17

10%

Question 18

most commonly seen association between cannabis and a mental health disorder is what disorder?

Answer 18

schizophrenia

Question 19

two risk factors for increasing your risk of developing schizophrenia

Answer 19

-age of use (younger you start using, more likely you are to get it)
-more potent product (more potent, more likely you are to get it)

Question 20

treatment of cannabinoid hyperemesis syndrome

Answer 20

-cannabis cessation
-benzos (antianxiety)
-haloperidol (antinausea)
-capsaicin cream (on abs)