Exam 5 (final) - Svensson cannabis Flashcards
hemp contains _____% or less THC
0.3%
marijuana contains _____% THC
15-20
synthetic marijuana contains analogs of THC that bind to _____ and ____ receptors as _____ agonists, unlike THC in non-synthetic marijuana, which is a ______ agonist at the same receptors
CB1, CB2, full, partial
T/F: cannabidiol binds to CB1 and CB2 receptors
F
dronabinol (Marinol) uses
-AIDS associated anorexia
-refractory chemotherapy-related N and V
-appetite stimulant in cancer pts
comes as synthetic delta-9 THC in sesame oil
nabilone (Casamet) uses
chemotherapy related N and V
cannabidiol (Epidolex) uses
2 rare seizure disorders:
Dravet syndrome
Lennox-Gastaut syndrome
what is cannabinoid hyperemesis syndrome
prolonged, excessive cannabinoid ingestion that leads to ab pain and cyclic vomiting
-often pts will take hot baths/showers to relieve symptoms
primary euphoric agent in cannabis
delta-9 THC
4 main components of Endocannabinoid System (ECS) in CNS
-receptors (CB1 and CB2)
-ligands (anandamide and 2-AG)
-transporter (endocannabinoid membrane transporter-EMT)
-enzymes (FAAH, MAGL, DAG)
CB1 is predominantly expressed in ____ (brain or periphery)
brain
CB2 is predominantly expressed in ____ (brain or periphery)
periphery
CB1 receptor expression is ______ in respiratory centers of brainstem
low
T/F: CBD products are regulated by FDA
F
-and they may contain highly variable amounts of THC and CBD
THC content in cannabis samples seized by DEA has markedly ______ over the past ~25 years
increased