Exam 5 - Anti-Hyperlipidemic Drugs Hockerman

Question 1

which is described below?

-essential component of cell membranes
-precursor to sterols and steroids

a. cholesterol
b. triglyceride (triacylglycerol)

Answer 1

a. cholesterol

Question 2

which is described below?

-storage form of fuel to support generation of high energy compounds
-component of structural lipids

a. cholesterol
b. triglyceride (triacylglycerol)

Answer 2

b. triglyceride (triacylglycerol)

Question 3

true or false: both cholesterol and triglyceride (triacylglycerol) are transported in blood macromolecular aggregates known as lipoproteins

Answer 3

true

Question 4

what is the lipoprotein core made of? (2 things)

Answer 4

triglyceride & cholesterol ester

Question 5

which is the main cholesterol form in blood?

a. chylomicrons
b. VLDL
c. IDL
d. LDL
e. HDL

Answer 5

d. LDL

Question 6

which is involved in transport of dietary lipids from gut to liver & adipose tissue?

a. VLDL
b. IDL
c. LDL
d. HDL
e. chylomicrons

Answer 6

e. chylomicrons

Question 7

which apolipoprotein is structural in HDL and mediates reverse cholesterol transport?

a. ApoA-I
b. ApoB-100
c. ApoB-48
d. ApoE
e. ApoCII

Answer 7

a. ApoA-I

Question 8

which apolipoprotein is structural in chylomicrons and produced in the intestine?

a. ApoA-I
b. ApoB-100
c. ApoB-48
d. ApoE
e. ApoCII

Answer 8

c. ApoB-48

Question 9

____ ____ synthesis is the major source of cholesterol. _____ synthesis is most critical to total body burden

Answer 9

De novo; liver

Question 10

ratio of total cholesterol to HDL-cholesterol is key in assessing risk of CVD. Ratio of > ___ is associated with increased risk of CVD

Answer 10

4.5

Question 11

consequences of hypertriglyceridemia (3 of them)

Answer 11

-pancreatitis
-xanthomas (fat build up under surface of skin)
-inc risk of CHD

Question 12

bile acid sequestrants mechanism (2)

Answer 12

-inhibit reabsorption of bile acids from intestine by binding bile acids to form insoluble complex excreted in feces
-up-regulate LDL receptors in liver

Question 13

two bile acid sequestrant drugs from class

Answer 13

cholestyramine (Questran)
colestipol (Colestid)

(colesevelam is another one that Chaudry talked about)

Question 14

basic mechanism for upreg of LDL receptors by statins

Answer 14

statin is ingested, it goes to liver, inhibits HMG-CoA reductase, thus lowering cholesterol production. The dec in liver cholesterol activates SREBP processing