Exam 4 - NSAIDs Flashcards
Function of Cyclooxygenase (COX)
Enzyme that converts arachidonic acid into prostaglandins
Two groups of cyclooxygenase inhibitors
1 - NSAIDs
2 - Acetaminophen
Two subgroups of NSAIDs
1st gen NSAIDS (inhibit cox1 and cox2)
2nd gen NSAIDS (selective for inhibiting cox2)
Examples of NSAIDs
Aspirin
Celecoxib
Ibuprofen
Naproxen
Advil
Drugs without anti inflammatory properties
Acetaminophen
Action of first generation NSAIDS
Inhibit cox1 and cox2
What are first generation NSAIDs used for?
To treat inflammatory disorders
(Especially rheumatoid arthritis, osteoarthritis, bursitis)
Alleviate mild to moderate pain
Suppress fever
Prototype NSAID
Aspirin
Therapeutic uses of aspirin
Analgesic
Antipyretic
Anti-inflammatory
(Suppression of platelet aggregation, protects in thrombotic disorders)
Unique characteristic about aspirin that other NSAIDs do not have
Protects against MI and stroke
Adverse effects of Aspirin
GI effects: gastric upset, GI bleeding
Renal impairment
Salicylism (ringing in ears, N&V)
Reye’s syndrome in children
Hypersensitivity reaction
Risks of taking Aspirin during pregnancy
Anemia
Postpartum hemorrhage
May prolong labor
Drug interactions with Aspirin
Anticoagulants: Warfarin, Heparin
Glucocorticoids
Alcohol
Ibuprofen
ACE inhibitors and ARBs
Principle indications for non-Aspirin first gen NSAIDs
Rheumatoid arthritis
Osteoarthritis
Class of Ibuprofen
First generation NSAID