Exam 4: Drugs 2

Question 1

Levodopa

Answer 1

L-isomer of DOPA
Crosses BBB; crosses even more with carbidopa
On/off phenomenon
Prevents COMP from breaking down L-dopa

Question 2

Levodopa drug interactions

Answer 2

Vitamin B6 and MAOIs

Question 3

Levodopa contraindications (3)

Answer 3

1. Psychosis
2. Glaucoma
3. Melanoma

Question 4

Pimavanserin

Answer 4

Antipsychotic taken w/ carbidopa
DO NOT JUST TAKE IT IT IF NOT ON CARBIDOPA
Inverse agonist at 5HT 2A

Question 5

Selegeline

Answer 5

MAO-B selective MAOI
Early treatment for alzheimers

Question 6

Tolcapone

Answer 6

COMT inhibitor = inc. circulating dopamine

Question 7

Apomorphine

Answer 7

Dopamine agonist
Good during the on/off phenomenon
Relief akinesia

Question 8

Baclofen

Answer 8

MM relaxer
Cerebral palsy

Question 9

Tetrabenazine

Answer 9

Benign herediary chorea

Question 10

Haloperidol

Answer 10

Huntington’s disease; dopamine receptor blocker

Question 11

Riluzole

Answer 11

ALS treatment
Sodium channel blocker

Question 12

Tacrine

Answer 12

Alzheimer’s
CNS Ach esterase inhibitors

Question 13

Memantine

Answer 13

Alzheimer’s
NMDA Receptor antagonist; GABA receptor

Question 14

Tremor

Answer 14

rhythmic movement around a joint
HALLMARK OF PARKINSONISM

Question 15

Intentional tremors are found with what 2 things?

Answer 15

Brain lesions
Drug toxicity

Question 16

Chorea

Answer 16

muscle jerks in various areas

Question 17

Ballismus

Answer 17

subtype of chorea; WILD movement/jerking
HUNTINGTON’S DISEASE

Question 18

Athetosis

Answer 18

slow writhing-like movement

Question 19

Dystonia

Answer 19

abnormal posture not associated w/ movement