EXAM #4 Flashcards
Functions of the urinary system
- Elimination
- Excretion
- Homeostatic regulation of blood plasma by the kidneys
Functions of the urinary system:
Role of ureters, bladder, urethra
- Discharge of waste products out of body
Elimination
Functions of the urinary system:
_ first than _ second
- excretion
- elimination
Functions of the urinary system:
Role of the kidney
- Remove of organic waste products from body fluids, produce urine
Excretion
Functions of the urinary system:
3. Homeostatic regulation of blood plasma by the kidney
- Regulating blood _ & _
- volume & pressure
Functions of the urinary system:
3. Homeostatic regulation of blood plasma by the kidney
- Regulating plasma _ concentrations
ion
Functions of the urinary system:
3. Homeostatic regulation of blood plasma by the kidney
- Stabilizing _
blood pH
Functions of the urinary system:
3. Homeostatic regulation of blood plasma by the kidney
- conserving _
nutrients
Functions of the urinary system:
- Regulating blood volume & pressure
- Regulating plasma ion concentrations
- Stabilizing blood pH
- Conserving nutrients
Homeostatic regulation of blood plasma by the kidney
Kidney tissue:
- _ contains ~1.25 million nephrons that make urine
Cortex
Kidney tissue:
- Medulla consists of _ that drain urine from nephron to calyces
collecting ducts
Kidney tissue:
_ drain into central renal pelvis
Calyces (plural of calyx)
Kidney tissue:
Renal pelvis drains into the _
ureters
Kidney has extensive _
- Kidneys receive 20-25% of cardiac output
vascular system
The nephron consists of a renal _ and renal _
- corpuscle
- tubule
The nephron:
Renal corpuscle is composed of _
Bowman’s capsule and the
glomerulus capillary bed
The nephron:
_ consists of
- Proximal convoluted tubule (PCT)
- Nephron loop (Loop of Henle)
– Descending limb
– Ascending limb
- Distal convoluted tubule (DCT)
Renal tubule
Blood supply to the nephrons:
Glomerulus
_ arterioles & _ arterioles
afferent arterioles & efferent arterioles
Blood supply to the nephrons:
Glomerulus
- _ arterioles supply blood to
capillary bed of glomerulus in the renal corpuscles
Afferent
Blood supply to the nephrons:
Glomerulus
- _ arterioles collect blood _
glomerulus capillary bed
- Efferent
- leaving
Blood supply to the nephrons:
Glomerulus
- _ exits capillaries into renal tubules
Filtrate
Blood supply to the nephrons:
Renal tubules
- _ surround renal tubules - collect nutrients, water, and ions reabsorbed out of filtrate
Peritubular capillaries
Two types of nephron
- cortical nephrons
- Juxtamedullary nephrons
Type of nephron:
- ~85% of all nephrons
- Loops of Henle are shorter and mostly within the cortex
cortical nephrons
Type of nephron:
Cortical nephrons loops of Henle are _ and mostly within the cortex
shorter
Type of nephron:
- Loops of Henle are longer and extend deep into renal pyramids
- Produce more concentrated urine
– More water reabsorbed
Juxtamedullary nephrons
Type of nephron:
Juxtamedullary nephrons
- Loops of Henle are _ and extend deep into renal pyramids
longer
Type of nephron:
Juxtamedullary nephrons
- Produce more _ urine
– More water reabsorbed (less water wasted)
concentrated
Basic process of urine formation
- Filtration
- Reabsorption
- Secretion
Basic process of urine formation:
- Blood pressure causes water & solutes to move out of glomerular capillaries into renal tubules
Filtration
Basic process of urine formation:
Filtration
- _ - Fluid within renal tubule
Filtrate (tubular fluid)
Basic process of urine formation:
- Removal of water and solutes from filtrate into peritubular fluid (then blood)
Reabsorption
Basic process of urine formation:
Reabsorption
- _ - interstitial fluid surrounding renal tubule and peritubular capillaries
Peritubular fluid
Basic process of urine formation:
- Transport of solutes from the (blood to) peritubular fluid into the filtrate
Secretion
Composition and volume of normal urine varies with the _ and _ events of the body
- metabolic
- hormonal
Composition and volume of normal urine:
_ liters per day of filtrate produced
180
Composition and volume of normal urine:
180 liters per day of filtrate produced – _ is reabsorbed
99%
Composition and volume of normal urine:
1.2 liters (1200 ml ) per day of _ produced
urine
Composition and volume of normal urine:
Failure of kidneys to _ would be fatal in a few hours
(dehydration)
concentrate urine
Composition and volume of normal urine:
- Blood/filtrate ~ _ mOsm/liter
300
Composition and volume of normal urine:
- Blood/filtrate pH = _
7.35-7.45
Composition and volume of normal urine:
- Urine ~ _ mOsm/liter
850 to 1300
Composition and volume of normal urine:
- Urine pH = _
4.5-8.0
Three metabolic wastes
- Urea
- creatinine
- uric acid
Composition and volume of normal urine:
Wastes are eliminated only when _ in urine, so removal
is accompanied by _
- dissolved
- water loss
Urine production:
Glomerulus – produces _ similar in composition to plasma without plasma proteins
filtrate
Urine production:
_ – produces filtrate similar in composition to plasma without plasma proteins
Glomerulus
Urine production:
PCT- reabsorbs _ by carrier
mediated transport and 60-70% of by _ osmosis
- nutrients & ions
- H2O
Urine production:
_ - reabsorbs nutrients & ions by carrier mediated transport and 60-70% of by H2O osmosis
Proximal convoluted tubule (PCT)
Urine production:
_ - reabsorbs H2O by osmosis
Descending limb
Urine production:
Descending limb - reabsorbs _ by osmosis
H2O
Urine production:
Thick ascending limb - reabsorbs _ and _
- Na+
- Cl-
Urine production:
_ - reabsorbs Na+ and Cl-
Thick ascending limb
Urine production:
DCT and collecting ducts – function depends on levels of _
hormones
Urine production:
_ – function depends on levels of hormones
Distal convoluted tubules (DCT) and collecting ducts
Reabsorption and secretion:
occur via diffusion, osmosis, and carrier-mediated
transport across _ forming the wall of renal tubule
epithelial cells
3 Carrier Mediated transport
- Facilitated diffusion
- Active transport
- Cotransport & Countertransport
Characteristics of Carrier
Mediated Transport:
- specific for a particular molecule
- transport only in one direction
- distribution of carrier proteins vary
- Can be controlled by hormones
carrier proteins
Characteristics of Carrier
Mediated Transport:
carrier proteins
- _ for a particular molecule
specific
Characteristics of Carrier
Mediated Transport:
carrier proteins
- transport only in _
one direction
Characteristics of Carrier
Mediated Transport:
carrier proteins
- distribution of carrier proteins _
vary
Characteristics of Carrier
Mediated Transport:
carrier proteins
- Can be controlled by _
hormones
Characteristics of Carrier
Mediated Transport:
carrier proteins have a _
transport maximum (Tm)
Characteristics of Carrier
Mediated Transport:
carrier proteins have a transport maximum (Tm)
- Determines _ for reabsorption of substances in tubular fluid
- Excess is _
- renal threshold
- “lost” in urine
Filtration and the Glomerulus:
_ forces water and solutes out of glomerular capillaries
Blood pressure
Filtration and the Glomerulus:
Large molecules such as
plasma proteins _ due to 3 layers of glomerulus filtration
do not cross
Filtration and the Glomerulus:
3 layers of glomerulus filtration
- Capillary endothelium
- Lamina densa
- Podocytes cover lamina
densa
Filtration and the Glomerulus:
3 layers of glomerulus filtration
- specialized basal lamina
Lamina densa
Filtration and the Glomerulus:
3 layers of glomerulus filtration
- Podocytes cover lamina
densa of capillaries producing _
filtration slits
Filtration at Glomerulus:
Net filtration pressure is sum of opposing forces
FP = GHP - CsHP - BOP
Filtration at Glomerulus:
Net filtration
- blood hydrostatic pressure in glomerular capillaries pushing _ (GHP)
fluids & solutes out
Filtration at Glomerulus:
Net filtration
- capsular hydrostatic pressure pushing _ capillaries (CsHP)
fluids & solutes into
Filtration at Glomerulus:
Net filtration
- blood osmotic pressure _ capillaries (BOP)
pulling water into
Filtration at Glomerulus:
- blood osmotic pressure (BOP) = _ mm Hg
25 (OP)
Filtration at Glomerulus:
- Capsular hydrostatic pressure (CsHP) = _ mm Hg
15
Filtration at Glomerulus:
- blood hydrostatic pressure (GHP) = _ mm Hg
50 (BP)
Filtration at Glomerulus:
Filtration pressure = (BP) 50 - (OP) 25 - (CsHP) 15 = _ mm Hg
10
Amount of filtrate produced in the kidneys each minute
Glomerular filtration rate
(GFR)
Glomerular filtration rate
(GFR):
Amount of filtrate produced in the kidneys each minute - - _ /minute = _/day
- 100 ml
- 180 liters
GFR is altered by any factors that alter net _
filtration pressure (FP)
GFR is altered by any factors that alter net filtration pressure (FP)
- Causing changes in _ of urine output and _ of urine
- volume
- composition
GFR altered by net filtration pressure (FP):
- Causing changes in urine output volumes & composition of urine
– Changes in _
– Changes in _ levels
- blood pressure
- blood osmotic
Glomerular filtration rate
(GFR):
Kidney has mechanisms to keep GFR at _
- Disease or damage can alter that
homeostasis
Factors affecting the GFR:
Decrease in GFR
- If GFR falls too low, can be fatal in a few days to weeks due to _
toxic waste buildup in blood
Factors affecting the GFR:
Decrease in GFR
_ will decrease filtration
Low BP
Factors affecting the GFR:
Decrease in GFR
- Low BP will decrease filtration
– Hemorrhage (blood loss), dehydration, or shock that _
dilates blood vessels
Factors affecting the GFR:
Decrease in GFR
- Glomerulonephritis
– _ of filtration slits by antigen-antibody complexes in blood
Blockage
Factors affecting the GFR:
Decrease in GFR
- Glomerulonephritis
– Blockage of _ by antigen-antibody complexes in blood
filtration slits
Factors affecting the GFR:
Decrease in GFR
- Glomerulonephritis
– Fluids _ move out of capillaries
can not
Factors affecting the GFR:
- Glomerulonephritis
– _, urine production falls
GFR decreases
Factors affecting the GFR:
Decrease in GFR
- _ is inflammation of kidney
Nephritis
Factors affecting the GFR:
Decrease in GFR
- Nephritis - inflammation of kidney
– Swelling causes _ so filtration rate slows
increased capsular pressure
Control of the GFR:
Autoregulation of _ can keep GFR constant despite changes in _
- afferent and efferent arteriole diameters
- systemic BP
Control of the GFR:
Autoregulation of afferent and efferent arteriole diameters can keep GFR constant despite changes in systemic BP
- Decreasing BP causes:
– Dilation of _ arteriole
afferent
Control of the GFR:
Autoregulation of afferent and efferent arteriole diameters can keep GFR constant despite changes in systemic BP
- Decreasing BP causes:
– Dilation of _ capillaries
glomerular
Control of the GFR:
Autoregulation of afferent and efferent arteriole diameters can keep GFR constant despite changes in systemic BP
- Decreasing BP causes:
– Constriction of _ arteriole
efferent
Control of the GFR:
_ causes:
- Dilation of afferent arteriole
- Dilation of glomerular capillaries
- Constriction of efferent arteriole
Decreasing BP
Control of the GFR:
Autoregulation of afferent and efferent arteriole diameters can keep GFR constant despite changes in systemic BP
- Increasing BP causes:
– _ of afferent arteriole
constriction
Control of the GFR:
_ causes:
- constriction of afferent arteriole
increasing BP
Control of the GFR:
_ regulation can over-ride autoregulation during stress response
Sympathetic ANS
Control of the GFR:
Sympathetic ANS regulation can over-ride autoregulation during stress response
- Hypotensive stress → strong vasoconstriction of
afferent arteriole, _ blood flow to _
- reducing
- glomerulus
Control of the GFR:
Sympathetic ANS regulation can over-ride autoregulation during stress response
- _ stress → strong vasoconstriction of
afferent arteriole, reducing blood flow to glomerulus
Hypotensive
Control of the GFR:
Sympathetic ANS regulation can over-ride autoregulation during stress response
- Overheating and exercise stress → _ from kidney by vasodilation of arterioles in skin and skeletal muscles
divert blood away
Control of the GFR:
Sympathetic ANS regulation can over-ride autoregulation during stress response
- _ stress → divert blood away from kidney by vasodilation of arterioles in skin and skeletal muscles
Overheating and exercise
Control of the GFR:
Sympathetic ANS regulation can over-ride autoregulation during stress response
- Reduced kidney perfusion & _
urine output
Role of kidney in systemic BP control:
Release of _ by juxtaglomerular apparatus (JGA)
renin
Role of kidney in systemic BP control:
Release of renin by JGA
- Stimulated by a drop in _
filtration pressure
Role of kidney in systemic BP control:
Release of renin by JGA
- Renin release –> formation of _
angiotensin II
Role of kidney in systemic BP control:
- _ —> Angiotensin I
Angiotensinogen
Role of kidney in systemic BP control:
_ converts angiotensiongen to angiotensin I
Renin
Role of kidney in systemic BP control:
- Angiotensin I —> _
Angiotensin II
Role of kidney in systemic BP control:
_ converts Angiotensin I to Angiotensin II
angiotensin converting enzyme (ACE)
Role of kidney in systemic BP control:
As blood passes through _ , _ converts angiotensin I to the active form angiotensin II
- lungs
- angiotensin converting enzyme (ACE)
Role of kidney in systemic BP control:
Angiotensin II produces increases in _ and _
- blood volume
- BP
Control of the GFR:
Effects of _
- constricts efferent arteriole
- Stimulates aldosterone secretion
- Stimulates antidiuretic hormone (ADH) secretion
- Stimulates thirst
- Stimulates sympathetic activation
angiotensin II
Control of the GFR:
Effects of angiotensin II
- _efferent arteriole
constricts
Control of the GFR:
Effects of angiotensin II
- Stimulates _ secretion
- Stimulates _ secretion
- aldosterone
- antidiuretic hormone (ADH)
Control of the GFR:
Effects of angiotensin II
- Stimulates _
thirst
Control of the GFR:
Effects of angiotensin II
- Stimulates _ activation
sympathetic
PCT _ 60-70% of filtrate
reabsorbs
PCT reabsorption of most organic nutrients by _
- Sugars, amino acids, vitamins, etc. up to transport maximum (Tm)
carrier mediated transport
PCT reabsorption of most organic nutrients by carrier mediated transport
- Genetic disorders exist in which genes for one or more of transport proteins are _
abnormal
PCT Reabsorption of _, _ and other ions
- sodium
- bicarbonate
PCT Reabsorption of _
water by osmosis
Nephron Loop (Loop of Henle):
- Reabsorbs water by osmosis
- Impermeable to solutes
Thin descending limb
Nephron Loop (Loop of Henle):
Thin descending limb
- Reabsorbs water by _
osmosis
Nephron Loop (Loop of Henle):
Thin descending limb
- Impermeable to _
solutes
Nephron Loop (Loop of Henle):
- Active NaCl reabsorption
- Impermeable to water
Thick ascending limb
Nephron Loop (Loop of Henle):
Thick ascending limb:
- Active _ reabsorption
NaCl
Nephron Loop (Loop of Henle):
Thick ascending limb:
- Impermeable to _
water
Nephron Loop (Loop of Henle):
Exchange between fluids moving in opposite directions
Countercurrent multiplication
Nephron Loop (Loop of Henle):
Countercurrent multiplication
- Exchange between fluids moving in _
opposite directions
Nephron Loop (Loop of Henle):
Countercurrent multiplication
- Increased osmolarity from NaCl transport from ascending limb results in increased movement of _ from descending limb
waste
Nephron Loop (Loop of Henle):
Countercurrent multiplication
- Increased osmolarity from _ from _ results in _ movement of waste from descending limb
- NaCl transport
- ascending limb
- increased
Tubes of smooth muscle ~12 inches long from kidney to bladder
Ureters
Ureters:
_ force urine toward the urinary bladder
Peristaltic contractions
Hollow organ – surrounded
by 3 layers of smooth muscle called the detrusor muscle
Urinary bladder
Urinary bladder:
Hollow organ – surrounded
by 3 layers of smooth muscle called the _
detrusor muscle
Urinary bladder:
_ innervation controls contraction of detrusor muscle which voids (empties) bladder
Parasympathetic
Urinary bladder:
Parasympathetic innervation controls _ which voids (empties) bladder
contraction of detrusor muscle
Elimination of urine:
Urethra
- at base of the bladder
- Smooth muscle, ANS control (involuntary)
Internal urinary sphincter
Elimination of urine:
Urethra
- Internal urinary sphincter
– at _ of the bladder
base
Elimination of urine:
Urethra
- Internal urinary sphincter
– Smooth muscle, _
ANS control (involuntary)
Elimination of urine:
Urethra
- In floor of pelvic cavity =
urogenital diaphragm
- Skeletal muscle, voluntary control
External urinary sphincter
Elimination of urine:
Urethra
- External urinary sphincter
– In _ cavity = urogenital diaphragm
floor of pelvic
Elimination of urine:
Urethra
- External urinary sphincter
– Skeletal muscle, _
voluntary control
expelling urine from urinary bladder through urethra
Urination (voiding)
Urination coordinated by _
micturition reflex
Micturition Reflex:
Stretch receptors in wall of bladder
- Provide _ awareness of bladder distension
conscious
Micturition Reflex:
Stretch receptors in wall of bladder
- Provide input to ANS causing reflex contraction of detrusor muscle via _
parasympathetic input
Urination requires _ micturition reflex with relaxation of internal and external urethral sphincter
coupling
Urinary Disorders:
Inability to voluntarily prevent the release of urine
Incontinence
Urinary Disorders:
Inability to voluntarily release urine
Urinary retention
- Incontinence
- Urinary retention
- Urinary tract infections
- Kidney Stones
Urinary Disorders
Changes with aging include:
Problems with the _
- Incontinence
- Urinary retention due to prostate gland hypertrophy in males
micturition reflex
Changes with aging include:
Higher incidence of _
- Calcium, magnesium, or uric acid crystals
- Amino acid crystals in genetic disorders of amino acid carrier-mediated transport proteins
kidney stones