EXAM 3 - Psychotic Disorders Flashcards

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1
Q

Psychosis

A

gross departure from reality, which may include

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2
Q

Hallucinations

A

Sensory experiences in the absence of sensory input (e.g. hearing voices)

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3
Q

Delusions

A

Strong, inaccurate beliefs that persist in the face of evidence to the contrary

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4
Q

Schizophrenia

A

A pervasive type of psychosis characterized by disturbed thought, emotion, behavior

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5
Q

Psychosis: History Thinking

A

Emil Kraepelin – used the term dementia praecox to describe schizophrenic syndrome
Early subtypes of schizophrenia – Catatonia, hebephrenia and paranoia
Eugen Bleuler – introduced the term “schizophrenia”
“Splitting of the mind”

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6
Q

Psychosis: History Thinking

Bleuler’s 4 A’s (1857-1938)

A

Association (Thought disorder: loosening of associations where ideas have little connection to each other)
Affect (Decreased or inappropriate)
Ambivalence (Simultaneous opposite feelings)
Autism (Withdrawal from reality and illogical, fantasy-ruled thinking)

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7
Q

Positive (additive) Symptoms of Schizophrenia

A
Delusions
Disorganized Speech
Disorganized and bizarre behavior
Hallucinations
Unusual motor behavior
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8
Q

Negative Symptoms of Schizophrenia

A

Flat affect
Loss of energy
Loss of motivation
Loss of feelings of pleasure

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9
Q

Disorganized” Symptom Cluster

A

Confused or abnormal speech, behavior, and emotion
Nature of disorganized speech
Cognitive slippage – illogical and incoherent speech
Tangentiality – “going off on a tangent”
Loose associations – conversation in unrelated directions
Nature of disorganized affect
Inappropriate emotional behavior
Nature of disorganized behavior
Includes a variety of unusual behaviors
Catatonia
May be considered a psychotic spectrum disorder in its own right or, when occurring in the presence of schizophrenia, a symptom of schizophrenia

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10
Q

Subtypes of Schizophrenia: A Thing of the Past

A

Schizophrenia was previously divided in to subtypes based on content of psychosis
This is no longer the case in DSM-5, but outdated terms are still in partial use
Included paranoid, catatonic, residual (minor symptoms persist after past episode), disorganized (many disorganized symptoms) and undifferentiated

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11
Q

Former Subtypes of Schizophrenia in DSM-IV

A

Paranoid (Delusions of persecution or grandeur. May trust no one or be anxious or angry about supposed tormentors)
Disorganized (Incoherent speech and inappropriate, often silly, emotion. May be very withdrawn, have odd grimaces and mannerisms)
Catatonic (Bizarre physical movements, ranging from motionless stupor to violent hyperactivity, sometimes alternating)
Undifferentiated (Delusions, hallucinations, and incoherence, but doesn’t fit into any of the other subtypes)
Residual (Minor symptoms of schizophrenia lingering after a serious episode)

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12
Q

DSM-5 Diagnostic Criteria for Schizophrenia

A

A. Two or more of the following, each present for a significant portion of time during a 1-month period (or less if successfully treated). At least one of these must be (1), (2), or (3):

  1. Delusions.
  2. Hallucinations.
  3. Disorganized speech (e.g., frequent derailment or incoherence).
  4. Grossly disorganized or catatonic behavior. 5. Negative symptoms (i.e., diminished emotional expression or avolition).

B. For a significant portion of the time since the onset of the disturbance, level of functioning in one or more major areas, such as work, interpersonal relations, or self-care, is markedly below the level achieved prior to the onset (or when the onset is in childhood or adolescence, there is failure to achieve expected level of interpersonal, academic, or occupational functioning).

C. Continuous signs of the disturbance persist for at least 6 months.This 6-month period must include at least 1 month of symptoms (or less if successfully treated) that meet Criterion A (i.e., active-phase symptoms) and may include periods of prodromal or residual symptoms. During these prodromal or residual periods, the signs of the disturbance may be manifested by only negative symptoms or by two or more symptoms listed in Criterion A present in an attenuated form (e.g., odd beliefs, unusual percepptual experiences).

D.Schizoaffective disorder and depressive or bipolar disorder with psychotic features have been ruled out because either 1) no major depressive or manic episodes have occurred concurrently with the active-phase symptoms: or 2) if mood episodes have occurred during active-phase symptoms, they have been present for a minority of the total duration of the active and residual periods of the illness.

E. The disturbance is not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication) or another medical condition.

F. If there is a history of autistic spectrum disorder or a communication disorder of childhood onset, the additional diagnosis of schizophrenia is made only if prominent delusions or hallucinations, in addition to the other required symptoms of schizophrenia, are also present for at least 1 month (or less if successfully treated).

Specify if:
With catatonia

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13
Q

Incidence rate of Schizophrenia (1%)

A

Higher incidence rate for 1st degree relatives of individuals with schizophrenia, especially of parents and identical twins with schizophrenia

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14
Q

Schizophrenia: Statistics

A

Schizophrenia affects males and females about equally
Females tend to have a better long-term prognosis
Onset slightly earlier for males

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15
Q

The Course of Schizophrenia

A
Prodromal phase
85% experience
1-2 years before serious symptoms
Less severe, yet unusual symptoms:
Ideas of reference
Magical thinking
Illusions
Isolation
Marked impairment in functioning
Lack of initiative, interests, or energy
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16
Q

Other Psychotic Disorders

A
Schizophreniform Disorder 
Schizoaffective Disorder  (Bipolar or Depression types)
Delusional Disorder
Brief Psychotic Disorder
Shared Psychotic Disorder (Folie A Deux)
17
Q

Schizophreniform: DSM-5 Criteria

A

picture slide 21

18
Q

Schizoaffective Disorder: DSM-5

A

picture slide 23

19
Q

Schizoaffective disorder

A

Symptoms of schizophrenia + additional experience of a major mood episode (depressive or manic)
Psychotic symptoms must also occur outside the mood disturbance
Prognosis is similar for people with schizophrenia
Such persons do not tend to get better on their own

20
Q

Delusional Disorder: DSM-5

A

picture slide 26

21
Q

Catatonia

A

Unusual motor responses, particularly immobility or agitation, and odd mannerisms
Tends to be severe and quite rare
May be present in psychotic disorders or diagnosed alone, and may include:
Stupor, mutism, maintaining the same pose for hours
Opposition or lack of response to instructions
Repetitive, meaningless motor behaviors
Mimicking others’ speech or movement

22
Q

Catatonia: DSM-5

A

pic slide 28

23
Q

Psychotic Disorders Due to Other Causes

A

Psychosis may occur as the result of substance use, some medications and some medical conditions
Include:
Substance/medication-induced psychotic disorder
Psychotic disorder associated with another medical condition

24
Q

Substance/Medication-Induced Psychotic Disorder

A

slide 30

25
Q

Psychotic Disorder Associated with another Medical Condition

A

slide 31

26
Q

Brief Psychotic Disorder

A

Positive symptoms of schizophrenia (e.g., hallucinations or delusions) or disorganized symptoms
Lasts less than 1 month
Briefest duration of all psychotic disorders
Typically precipitated by trauma or stress

27
Q

Brief Psychotic Disorder: DSM-5

A

slide 33

28
Q

Causes Etiology of Schizophrenia - Psychoanalytic Theory

A

Weak Ego
Breakdown of Defense Mechanisms
No evidence

29
Q

Causes Etiology of Schizophrenia - Neofreudians

A

Parent-child relations that are hostile and results in anxiety
The individual, therefore, withdraws from reality and people
No evidence

30
Q

Causes Etiology of Schizophrenia - Family Theories

A

Fromm-Reichman’s “schizophrenogenic mother” (double-bind communication)
No evidence

31
Q

Causes Etiology of Schizophrenia - Existential Theory (R.D. Laing’s “Sanity, Madness and the Family”)

A

The False self has been stripped away
Psychosis is a break through toward the search for the authentic self
No evidence

32
Q

Causes Etiology of Schizophrenia - Biological Theories

A

Genetic predisposition is evident
Higher concordance of schizophrenia in monozygotic twins than dizygotic twins
Gottesman & Shield (1972) found a concordance rate of 42% in MZ twins and 9% in DZ twins
This has been replicated several times
Adoption studies confirm genetic evidence
Multiple genes have been associated with schizophrenia and 3 genes in particular are implicated as risk factors (Sections of Chromosome 8 (NRG1), Chromosome 6 (DTNBP1), and Chromosome 22 (COMT). COMT plays a role in Dopamine metabolism, which is disrupted in schizophrenia.

33
Q

Causes Etiology of Schizophrenia - Neurochemical Studies focus on dopamine

A

Neuroleptics block dopamine receptors and reduce the positive symptoms
Amphetamines at high doses can induce a psychotic-like state (they increase available dopamine)

There may be abnormalities in the migration of neurons in utero development during the 2nd trimester of pregnancy

34
Q

Etiology of Schizophrenia

A

Recent PET scan study indicates that a tiny variation in a gene that makes the enzyme COMT may put individuals at risk for schizophrenia (Chromosome 22)
COMT breaks down dopamine
Dopamine and dopamine receptor sites are affected by antipsychotic medications thus the role of COMT is very important
Likely impacts communication among neurons

35
Q

Biological Theories - Neuroanatomy (Abnormalities)

A

Prefrontal Cortex is likely involved
Hippocampus (temporal lobe); smaller neurons
Enlarged ventricles in some patients
Changes in the organization of the nerve cells
Possibly higher incidence of maternal flu during the second trimester of pregnancy (weak evidence)

36
Q

Other Neurobiological Influences

A

Marijuana use also increases the risk for developing schizophrenia in at-risk individuals
Conclusions about neurobiology and schizophrenia
Schizophrenia reflects diffuse neurobiological dysregulation
Structural and functional brain abnormalities
Not unique to schizophrenia

37
Q

Medications Used To Treat Schizophrenia

A

Older (“first generation”) antipsychotics (neuroleptics)
Thorazine the first FDA approved antipsychotic (mid 1950’s)
Haldol, Navane
Had a lot of side effects (ex., tardive dyskinesia)

38
Q

Medications Used to Treat Schizophrenia

A

Atypical antipsychotics
Act on different dopamine receptor sites than the first generation antipsychotics, and also affect other neurotransmitters to varying degrees
Help 30% of patients who were nonresponsive to older antipsychotics
Cozaril, Risperidal, Seroqual, Zyprexa, Geodon, Abilify, Latuda
Fewer side effects too (especially Geodon and Abilify)

39
Q

Integrative Treatment

A

Medication
Psychosocial Rehabilitation
Psychosocial Support