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MID Exam 3 > Exam 3 - Ortho-Paramyxoviruses > Flashcards

Exam 3 - Ortho-Paramyxoviruses Flashcards

1
Q

Paramyxoviruses

General profile

A
  • ss RNA viruses
  • lipid envelope
  • bud from cell surfaces
  • bind surface ligands, mem fusion
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2
Q

Paramyxoviruses
Parainfluenza virus
Clinical syndromes

A
  • URI/LRI
  • otitis media (15% of cases)
  • croup (laryngeotracheobronchitis)
  • bronchiolitis, bronchiectasis
  • pneumonia (esp w/ immunosuppression)
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3
Q

Paramyxoviruses
Rubula/Mumps
epi/transmiss

A
  • imported from UK
  • human res
  • direct contact, droplets, fomites
  • MMR vaccine (diminishes over time)
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4
Q

Paramyxoviruses
Rubula/Mumps
clinical

A
  • parotitis
  • epididymo-orchitis
  • meningitis/encephalitis
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5
Q

Paramyxoviruses
Morbilli/Measles
epi/transmiss

A
  • winter/spring (unusual!)
  • nasopharyngeal droplets
  • highly contagious
  • MMR
  • still active in US
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6
Q

Paramyxoviruses
Morbilli/Measles
pathogenesis

A
  • URI
  • viremia
  • resp, GI, GU, vessels, lymph, CNS
  • Dz is T cell response to virus in cap beds
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7
Q

Paramyxoviruses
Morbilli/Measles
clinical pres

A
  • koplik spots on cheeks (dx)
  • maculopap rash after 2 wks
  • face > trunk/limbs
  • pneumonia
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8
Q

Paramyxoviruses
RSV (resp synct virus)
epi/transmiss

A
  • winter/spring
  • all children infected at some pt
  • 2 subtypes
  • respiratory secretions
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9
Q

Paramyxoviruses
RSV
clinical

A
  • bronchiolitis
  • pneumonia (mononuclear infiltration)
  • apnea, wheezing, bronchiectasis
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10
Q

Paramyxoviruses
RSV
Tx

A
  • aerosolized ribavirin

- prevention

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11
Q

Paramyxoviruses
Metapneumovirus
epi/transmiss

A
  • similar to RSV
  • winter months
  • co-infection w/ RSV
  • vacc in development
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12
Q

Orthomyxoviruses
Influenza
general profile

A
  • ss RNA viruses
  • lipid envelope
  • types A, B, C
  • NA and HA surface receptors
  • serotypes based on receptors
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13
Q

Orthomyxoviruses
Influenza
epi/transmiss

A
  • BIRD RESERVOIR!
  • can reassort in piggy-pies
  • aerosolized
  • young and elderly
  • vaccines (trivalent (d)
  • antigenic drift (partial, minor) or shift (total, major)
  • reassortment
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14
Q

Orthomyxoviruses
Influenza
pathophys

A
  • URI, LRI
  • infects columnar epithelium
  • loss of mucociliary fxns
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15
Q

Orthomyxoviruses
Influenza
clinical pres

A
  • RIGORS, fever, myalgias, headache
  • sore throat, dry cough, rhinorrea/congestion
  • viral pneumonia
  • seconary bacterial pneum
  • rare guillan-barre
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16
Q

Orthomyxoviruses
Influenza
dx

A
  • rapid test

- can do PCR, but no one does

17
Q

Orthomyxoviruses
Influenza
relevant strains

A

H5N1
H7N5
all start in SE Asia
bird->human

MID Exam 3 (13 decks)

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