Exam 3 - Adeno--Parvoviruses Flashcards

1
Q

Adenoviruses

General Morphology

A

-non-enveloped DNA

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2
Q

Adenoviruses

Path

A
  • lytic phase (epithelium)
  • latent phase (lymphoid cells)
  • oncogenic transformation
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3
Q

Adenoviruses

Epi/transmiss

A

-usually primary infx’n in children

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4
Q

Adenoviruses

clin/sx

A
  • Pharyngoconjunctival fever (swimming pools)
  • epidemic keratoconjunctivitis (bilat)
  • hemorrhagic cystitis (esp boys)
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5
Q

Adenoviruses

dx

A
  • viral tissue culture, e- microscopy, Ab detection

- sputum, nasopharyngeal secretions, throat swab ELISA

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6
Q

Adenoviruses

tx

A
  • supportive tx

- sometimes antiviral for immunocompromised

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7
Q

Papillomavirus

morphology

A

-dsDNA

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8
Q

Papillomavirus

path

A

-binds tumor suppressor genese

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9
Q

Papillomavirus

Epi/transmiss

A
  • skin-skin or membrane-membrane contact
  • common/plane warts more common in children
  • plantar warts more common in adults
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10
Q

Papillomavirus
Cutaneous Warts
clin/sx

A

-deep plantar: painful, raised, keratotic
-common: demarcated, hyperkeratotic, hands
plan/flat: irregular contour, smooth

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11
Q

Papillomavirus
Anogenital
clin/sx

A
  • gray/fleshy, sessile/pedunculated
  • shaft of the peen, posterior introitus, labia, cervix, ayn
  • cervical cancer, anal cancer
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12
Q

Papillomavirus

dx

A
  • acetic sol’n
  • colposcopy
  • Pap
  • HPV DNA typing
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13
Q

Papillomavirus

tx

A

-topical salicylate, cryotherapy, lasers

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14
Q

Papillomavirus

prevention

A
  • Gardasil
  • against 4 types
  • most imp’t: types 16 and 18
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15
Q

Parvovirus B19

morphology

A

-small non-enveloped DNA

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16
Q

Parvovirus B19

path

A
  • propagates in erythroid progenitor cells
  • causes anemia with predisposed Pts
  • can cause aplastic crisis
17
Q

Parvovirus B19

transmiss/epi

A
  • children
  • 50% pop has serologic evidence
  • resp route
18
Q

Parvovirus B19

clin/sx

A

-Fifth Dz (erythema infectiosum): slapped face,
rash, immune-mediation
-Transient Aplastic Crisis: if Pt already has an anemic dz
-Pure Red Cell Aplasia: if combo’d w/ AIDS, immunosuppression

19
Q

Parvovirus B19

dx

A
  • DNA hybrid technology

- Fifth Dz is non-viremic (immune-mediated; IgM)

20
Q

Parvovirus B19

tx

A

-For immunosuppressed, med adjustment

or Igb tx