Exam 3 - Non-surgical Therapy Flashcards
What measurement identifies how much dental plaque (undisturbed oral biofilm) we accumulate per day?
82 to 200 um/day
If the effect of chlorhexidine was tested on undisturbed dental plaque following 1 min of exposure, what time period showed the most significant effect?
6 hr plaque.
- the effect of CHX on 24 and 48 hr place was limited to the outer layer. Middle and inner layers were not appreciably affected.
After SRP, what was the mean reduction in probing depth for the following probing depths
PD 7mm
What about mean gain in CAL?
PD 0.03 mm
PD 4-6 mm –> 1.29 mm
PD >7mm –> 2.16 mm
CAL:
PD -0.34 mm
PD 4-6mm –> 0.55 mm
PD >7mm –> 1.19 mm
List the instruments in order of their mean distance from the instrument limit to maximum pocket depth.
Gracy Curette (1.25 mm) Traditional Ultrasonic (1.13 mm) Ultrasonic Perio Insert (0.78 mm)
List the problems of restricted access
Probing depth Furcations Root proximity Root flutings CEJ relationships Restorations
Clinical protocol for non-surgical therapy
- OHI
- Electric power toothbrush
- Interproximal cleaning (flows, waterpik)
- Rinse with CHX twice daily
- SRP with local anesthesia
- Low Dose Doxycycline (periostat)
Smokers - Re-evaluation at 4-6 weeks post-SRP
- Retreat residual sites of >5mm (SRP or Site-specific drug delivery)
- If desired response is not achieved then consider surgical treatment
Low Dose Doxycycline was originally marketed as what?
Periostat
Name the dosage for Periostat
20 mg, #180 tabs, q. 12 h.
Describe the reasoning for 20 mg of dosage per tablet of Doxycycline
There is no bacterial effect at this dosage. However, doxycycline (like all tetracycline family) chelate calcium and other metals such as Zn and Mg. Therefore, the tetracycline drugs have the ability to inactivate matrix metalloproteinase - specifically the collagenases and gelatinizes produced by PMNs and macrophages
Where would you perform SRP + Local delivery of antimicrobial
- Pockets of > or = 5mm
- Maintenance patients with isolated PD of 5-6 mm
- Early stage periodontal abscess
- PD at the distal-facial line-angle of 2nd molars related to 3rd molar extractions
- Ailing implants (peri-implantitis)
- Furcations
3 locally delivered antimicrobials that are commercially available?
- Periochip
- Atradox
- Arestin
Describe Periochip
Chlorhexidine gluconate in a polymerized polylactic acid disc
Describe Atradox
Doxycycline in a poly-lactide gel that polymerizes on contact with water
Describe Arestin
1 mg of minocycline micro encapsulated in a poly-glycolide-co-lactide dry powder
To be effective, a locally delivered antimicrobial must do what 5 things?
- Kill or inhibit the appropriate target microbes
- Reach the disease site
- Achieve adequate concentration for effectiveness
- Achieve appropriate duration of effect
- Have few side effects and/or cause no harm to the patient
What microbes are susceptible to minocycline at concentrations of 2-8 ug/ml
Porphyromonas gingivalis Prevotella intermedia Fusobacterium nucleatum Eikenella corrodens Aggregatibacter actinomycetemcomitans
Mouth Rinse in its ratings of the following factors to treat Chronic Periodontitis? 1- Reach disease site 2- Achieve adequate concentration 3- Achieve adequate duration of effect 4- Kill/Inhibit target microbes 5- Does not harm patient
1 - Poor 2 - Good 3 - Poor 4 - Poor 5 - Good
Sub gingival irrigation in its ratings of the following factors to treat Chronic Periodontitis? 1- Reach disease site 2- Achieve adequate concentration 3- Achieve adequate duration of effect 4- Kill/Inhibit target microbes 5- Does not harm patient
1 - Good 2 - Good 3 - Poor 4 - Fair 5 - Good
Systemic Antibiotics in its ratings of the following factors to treat Chronic Periodontitis? 1- Reach disease site 2- Achieve adequate concentration 3- Achieve adequate duration of effect 4- Kill/Inhibit target microbes 5- Does not harm patient
1 - Good 2 - Fair 3 - Fair 4 - Good 5 - Fair
Locally Delivered Antimicrobial in its ratings of the following factors to treat Chronic Periodontitis? 1- Reach disease site 2- Achieve adequate concentration 3- Achieve adequate duration of effect 4- Kill/Inhibit target microbes 5- Does not harm patient
1 - Good 2 - Good 3 - Good 4 - Good 5 - Good
Describe the load of Arestin
1 mg of minocycline micro encapsulated in a poly-glycolide-co-lactide dry powder
GCF concentration of Arestin at following times:
- time of application
- Day 3
- Day 14
- Day 28
- 90,000 ug/ml at time of application
- 3,250 ug/ml at day 3
- 340 ug/ml at day 14
- 10-20 ug/ml at day 28
Open Flap Debride (4-6 mm pocket)
- Reduction in PD
- Change in CAL
Reduction: 3.00 mm
Change in CAL: 1.50 mm
SRP + Arestin (4-6 mm pocket)
- Reduction in PD
- Change in CAL
Reduction: 1.65 mm
Change in CAL: 1.05 mm
SRP treatment (4-6 mm pocket)
- Reduction in PD
- Change in CAL
Reduction: 1.30 mm
Change in CAL: 0.55 mm
SRP + Atridox (4-6 mm pocket)
- Reduction in PD
- Change in CAL
Reduction: 1.20 mm
Change in CAL: 0.88 mm
SRP + Actisite (4-6 mm pocket)
- Reduction in PD
- Change in CAL
Reduction: 1.10 mm
Change in CAL: 1.00 mm
SRP + PerioChip (4-6 mm pocket)
- Reduction in PD
- Change in CAL
Reduction: 0.90 mm
Change in CAL: 0.55 mm
Average Non-Surgical Therapy (4-6 mm pocket)
- Reduction in PD
- Change in CAL
Reduction: 1.23 mm
Change in CAL: 0.81 mm
Systemic antibiotics commonly used as adjuncts in the treatment of aggressive periodontitis include:
Amoxicillin (Amoxil or Trimox) Metronidazole (Flagyl) Tetracycline HCl (Sumycin) Doxycycline (Virbramycin) Clindamycin (Cleosin) Amoxicillin + Clavulanic Acid (Augmentin) Azithromycin (Zithromax or Z-pak)
Advantages in use of systemic antibiotics in the treatment of chronic periodonititis
- Affects bacterial reservoirs
- Targets multiple sites of infection
- Reduces chair time required to treat patients
- Absorb into soft tissues adjacent to infected site
- Penetrates to base of infected pocket
- Wide choice of different antibiotics
Disadvantages in use of systemic antibiotics in the treatment of chronic periodontitis
- Allergy
- Gastrointestinal intolerance
- Patient compliance
- Potential for drug interactions
- Cost to patient
- Inability to penetrate an intact biofilm
Problem of patient compliance of medications at 6 hours, 8 hours, 12 hours and 24 hours
(used in comparison to diabetics/insulin = 60% and Seatbelts = 70%
q. 6 h = 27%
q. 8 h = 40%
q. 12 h = 60%
q. 24 h = 75%
Common side effects of systemic antibiotics
- Gastrointestinal
- Nausea
- Photosensitivity
- Bacterial Resistance
- Esophagitis
- Candidiasis
What four systemic antibiotics may cause candidiasis as a side effect
Tetracycline HCl
Doxycycline
Minocycline
Amoxicillin
Clinical reasons for failure of systemic antibiotic therapy
- Patient non-compliance
- Inability to penetrate infection
- Inability to eradicate source of infection
- Cost to patient
- Inability to penetrate an intact biofilm
Treatment of chronic periodontitis by SRP + Arestin results in what?
significant decreases in levels of serum hsCRP and IL-6
Treatment of chronic periodontitis by SRP + sub-antimicrobial dose doxycycline results in what?
significant decreases in levels of GCF-MMPs (8 & 9), sCRP, HDL, and apolipoprotein-A (Apo-A)
What phase of treatment leads to most subsequent treatment decisions?
Re-evaluation
Where do most changes in the treatment plan occur?
During Re-evaluation
During Re-evaluation, what things are evaluated?
- Review Medical History
- Visual Examination
- Probing Depths
- Gingival Recession
- Clinical Attachment Levels
- Plaque control
- Bleeding on Probing
- Mucogingival Defects
- Furcation Involvements
- Mobility/Fremitus/Occlusion
- Caries
What 4 decisions are made during the Re-evaluation
- Control or re-address primary etiology
- Control or re-address etiologic modifying factors
- Proceed to Phase II (surgical therapy)
- Place in compromised maintenance therapy
List possible etiologic modifying factors
- Systemic disease
- Smoking
- Caries
- Diet
- Overhangs
- Occlusion
- Medications
- Parafunctional habits
During reevaluation, if a patient has improved to a level where the disease is stable and not other treatment is indicated, proceed to what phase?
Maintenance phase
During reevaluation, if there has been no improvement or disease is not stable, then proceed to:
Personalized Re-treatment
During Personalized Re-treatment, if sites are getting deeper or no improvement or if several sites are still exhibiting bleeding on probing, then proceed to:
Antimicrobial therapy (Systemic or Local)
Surgery
Combination
What is the most critical phase of successful periodontal therapy?
Maintenance
Treatment decisions in maintenance are based on?
Changes in probing depths
Presence of bleeding/plaque
Progressive loss of clinical attachment
During Maintenance, if probing depths are stable and there is no BOP, what do you do?
Routine Treatment, review OHI
Same recall interval
During Maintenance, if probing depths are stable but there IS BOP, what do you do?
Review OHI
Re-scale and root plane bleeding sites
Consider local delivery of antimicrobials
Consider shortening recall interval
During Maintenance, if probing depths increase and BOP increases, what do you do?
Review OHI Re-scale and root plane Consider adjunctive therapy - Locally delivered or systemic antibiotics Referral to a periodontist
How long is the normal interval between periodontal maintenance appointments
Every 3 months
- Time needed for pockets to re-infect is three months. i.e, pathogenic bacteria will begin to repopulate a pocket of >4 mm at 60+ days
T or F, Patients referred to a periodontist will generally be placed on an alternating maintenance schedule
True. patient will see GP every second appointment