Exam 3: Lecture 5, Targeted Therapy

Question 1

Standard Chemo vs Targeted Therapy

Answer 1

Non-specific vs specific

Many adverse effects vs may have less systemic toxicity

Question 2

primary Mechanism TKI

Answer 2

inhibit abnormal signals that lead to formation of neoplastic cells

Question 3

What do TKI have in common?

Answer 3

They’re all oral

Question 4

Targeted Therapy Limitations

Answer 4

cancer cells can become resistant to targeted agents so…
combo therapy of Targeted Therapy maybe best
or combo targeted therapy + chemo

another limitation is drugs for some targets hard to develop

Question 5

adverse effects with targeted therapy

Answer 5

most common: diarrhea and liver problems,

Interstitial long disease (ILD, <1%)

others: High BP, Blood clotting/wound healing, skin issues, GI perforation

may not all be bad, some ADRs linked to better outcomes

Question 6

Types of skin reactions

Answer 6

Changes how skin feels
Photosensitivity
Rash
Dry skin
Hand-foot syndrome

Question 7

Types of targeted therapy>

Answer 7

Antibodies (MABs)
Small molecules (TK inhibitors, immunomodulators,misc)
Vaccines

Question 8

Drugs block extracellular receptor?

Answer 8

Rituximab, trastuzumab

Question 9

Drugs act as carriers?

Answer 9

Ibritumomab = carry radiation
Brentuximab = carry microtubule disrupting agent

Question 10

Drugs trigger immune response?

Answer 10

Rituximab

Checkpoint inhib

Question 11

Sipuleucel T

Answer 11

cancer vaccine that stimulates immune system