Exam 3 (Ch. 44, 45, & 46) Flashcards
Nausea & Vomiting
Nausea is blank (objective or subjective) & is usually accompained by what?
Subjective
Anorexia
Nausea & Vomiting
What does anorexia mean?
Not E.D.
Lack of appetite, an abnormal loss of the appetite for food.
Nausea & Vomiting
Persistent vomiting leads to ?(4)
- Severe electrolyte imbalance
- Fluid volume loss
- Weight loss
- Eventual ciruclatory failure
GERD
What does GERD stand for and what is it?
Gastroesophageal Reflux Disease
A symptom of mucosal damage caused by reflux of stomach acid into the lower esophagus
Syndrome, not disease
Nausea & Vomiting
What are some treatments for N/V?
Antiemetic drugs
Scopolamine transdermal
Ondansetron (Zofran)
Promethazine
Metoclopramide (Reglan)
NPO
Intravenous Fluids
Nutritional therapy
Nausea & Vomiting
What will high frequent doses of Metoclopramide (Reglan) lead to?
Tardive Dyskinesia (frequent mouth movement)
What is the most common upper GI problem?
GERD
About 15 million Americans have GERD symptoms each day.
GERD
What are some symptoms & complications of GERD?
Heartburn
Chest Pain
Dyspepsia
Regurgitation
Wheezing/Coughing
Dyspnea
Hoarseness
Sore Throat
Esophagitis
Barrett Esophagus
Respiratory Complication
GERD
What is dyspepsia?
Pain or discomfort in the upper abdomen mainly in or around the midline.
GERD
What are some diagnostic test for GERD?
Endoscopy
Biopsy & cytologic specimens
Motility studies
Ambulatory esophageal pH monitoring
Radionuclide tests
GERD
Drug therapy for GERD focuses on what?
Decreasing the volume & acidity of reflux
Increasing esophageal clearance
Protecting the esophageal mucosa
GERD
What are some medications given for GERD? (6)
Esomeprazole (Nexium)
Omeprazole (Prilosec)
Pantoprazole (Protonix)
Famotidine (Pepcid)
Calcium carbonate (Tums)
Sucrafate (Carafate)
PUD
What does PUD stand for and what is it?
Peptic Ulcer Disease
Erosion of GI mucosa from HCl acid and pepsin
PUD
What area of the GI tract are susceptible to PUD?
Lower esophagus
Stomach
Duodenum
Post-op gastrojejunal anastomosis
PUD
PUD is classified by degree and duration of mucosal involvement and by location.
What is Acute and what is Chronic
Acute—superficial erosion and minimal inflammation
Chronic—Erosion of muscular wall with formation of fibrous tissue; present continuously for many months or intermittently throughout lifetime – more common
Gastric Ulcers
Who is gastric:antrum more prevalent in? What are they at an increased risk for? What are the risk factors? What is the mortality & recurrence rate?
More prevalent in females older than 50 years
Increased obstruction
Risk factors: Helicobacter pylori, NSAIDs, bile reflux
Increased mortality
High recurrence
Gastric Ulcers
Who is duodenal:1-2cm more prevalent in? What are is the etiology? What do these ulcer cause a high secretion of? What are the risk factors? What is the recurrence rate?
Prevalent ages 35 to 45
Etiology: H. pylori
High HCL secretion
High risk: COPD, cirrhosis, pancreatitis, hyperparathyroidism, Zollinger-Ellison syndrome, CRF (Chronic renal failure)
Occur, disappear, recur
Risk Factors and Clinical Manifestations
How is H. pylori is transmitted & what does the bacteria produce?
Transmission
* From family members to a child
* Oral-oral or fecal-oral
Bacteria produce urease
* Increased gastric section, tissue damage
Risk Factors and Clinical Manifestations
What may make someone more susceptible to H. pylori?
Medication-Induced Injury
* NSAIDs; especially with Corticosteroids or anticoagulants
Lifestyle factors
Risk Factors and Clinical Manifestations
How is a gastric ulcer presented in a pt? What is the first symptom in some pts?
Epigastric discomfort 1 to 2 hours after meal; burning or gaseous pain; food may worsen
Perforation is first symptom in some patients
Risk Factors and Clinical Manifestations
What might the pain from a duodenal ulcer feel like?
Burning or cramplike pain in midepigastric or back; 2 to 5 hours after meal
Risk Factors and Clinical Manifestations
What S/S do gastric & duodenal ulcers have in common?
Bloating, nausea, vomiting, early feeling of fullness
- May be silent (older adults and NSAIDs)
Gastric Ulcers: Diagnostic Studies
What are some diagnositc studies for gastric ulcers?
Endoscopy
- Obtain specimens for H. pylori Rule out stomach cancer
Biopsy of antral mucosa w/testing for urease
* Gold standard for H. pylori
Non-invasive tests: serology, stool, breath testing
Other tests: barium contrast, high fasting serum gastrin levels, secretin stimulation
Labs: CBC, liver enzymes, serum amylase
Stool is tested for blood
Gastric Ulcer: Interprofessional Management
What are some key parts of drug therapy gastic ulcer treatment?
Reduce gastric acid secretion (PPI)
Eliminate H. pylori (antibiotics and PPI)
Patient education: adherence important; teach about drugs; report recurrence of pain or blood in vomitus or stool