Exam 3 Flashcards
Translocation (parts are moved around) is
not a big deal; still have same number of genes
tumors that are cancerous and dangerous
Malignant
Mitotic stage has which 2 stages?
Mitosis and Cytokinesis
Proteins are made from a
DNA gene
Homologs in center of spindle (independent assortment)
Metaphase I
sister chromosomes are at the end of which stage?
S
Checkpoints are
highly regulated; prevents skipping and premature cell division
A diploid zygote happens because
haploid gametes fuse during fertilization
Mitosis has how many stages?
5
Name the 5 stages of mitosis in order
Prophase, metaphase, anaphase, telophase, cytokinesis
Are animals diploid or haploid?
Diploid
_____ control almost everything in a cell
Proteins
Meiosis I stages are:
Prophase I Metaphase I Anaphase I Telophase I Cytokinesis
Chromosomes align at metaphase plate
Metaphase II
This generates genetic variation:
Independent Assortment; happens during metaphase
G2 is:
Gap 2; final prep for division
Gametes are haploid or _:
n
Stages 1-3 are also known as:
Interphase
Many life forms have ___ copies of each chromosome
2
Name the “phase” of mitosis:
Sister chromatids separate into new cells
–now called daughter chromosomes
Anaphase
Chromosomes are visible at the end of which stage?
G2
Name the “phase” of mitosis:
Chromosomes are forced to align in the middle of the cell (forced by the spindle)
Metaphase
Offspring of F1 generation is known as
F2
mistakes in anaphase I and II are known as
nondisjunction
malignant tumors can _____ which means they can move throughout the body
Metastasize
Parental generation is also known as
P generation
G1 is:
Gap 1; Growth
No programmed cell death is known as:
Apoptosis
trisomy:
3 chromosomes
one cell going through division is known as the
cell cycle
DNA gene —> transcription —-> RNA —–> translation —> protein
how it works
Cleavage furrow forms and 4 haploid cells form which are all genetically different
Telophase II
S is:
DNA synthesis
Name the "phase" of mitosis: 2 clusters of DNA -Will become nuclei -Will become diploid Spindle disappears
Telophase
Sister chromatids separate in this meiosis stage; centromere dissolves
Anaphase II
when original tumor fragments travel through the bloodstream and lymphatic system and cause new tumors to appear:
Metastasizing
Offspring of parental generation is also known as
F1
cell size increases in which stage?
A) G1
B) S
C) G2
G1
All 4 cells become sperm:
Spermatogenesis
1 diploid cell divides into 4 haploid cells
meiosis
Some nerve and muscle cells stay in interphase, this is known as
G0
Division of the cytoplasm:
Cytokinesis
Name the “phase” of mitosis:
-Division of the cytoplasm
In animals: Cleavage furrow appears between daughter nuclei contractile ring of actin filaments —> works like a drawstring
Cytokinesis
Protein or action of those proteins; observable traits
Phenotype
Is the development of cancer spontaneous or gradual?
Gradual
At the end of S, cells are now __n
4n, meaning there are 4 copies of each of them
Each cell now has one copy of the chromosome
Telophase I
Children always look like the parent for a given trait. Same phenotype (homozy D or homozy r)
True Breeding
When a tumor secretes VEGF molecule, it causes what to happen?
surrounding tissue to form new blood vessels. blood vessel now “feeds” the tumor
Exchange of DNA between non-sister chromatids in Meiosis I
Crossing-over
Aa genotype is
heterozygous
Production of sperm and egg cells by meiosis:
Gametogenesis
Non-specialized and immortal, have an uncontrolled cell cycle, form tumors, have abnormally shaped nuclei: are ______ cell characteristics
Cancer
division of DNA in nucleus, daughter chromosomes equally split into two daughter nuclei
Mitosis
The Cell splits during:
Cytokinesis
DNA splits during:
Mitosis
Varieties that different in only 1 trait
monohybrid cross
origins of cancer starts with a defect in
cellular communication
sexually combining gametes is called _____ in plants
cross
Homologs separate from diploid to haploid
Anaphase I
having 2 copies of a chromosome is known as a
diploid organism
Name the “phase” of mitosis:
-DNA condenses, each chromosome becomes 2 sister chromatids attached at the centromere; spindle begins to assemble
Prophase
these promote the cell cycle, increase cell cycle/number, and if misregulated-can lead to cancer
Oncogens
These retain the ability to divide and go through the cell cycle
Stem cells
1 of 3 major cyto skeletal elements
Actin
When cell communication is disrupted
tumors develop
________ or interphase II is a period of rest that cells of some species enter during meiosis, between meiosis I and meiosis II
Interkinesis
heredity, radiation sources, pesticides and herbicides, and viruses are
Mutations that cause cancer
She helped to develop polio vaccine, discover telomerase, and link HPV to cancer. Cells known as HeLa cells
Henrietta Lacks
cell division that makes cells have 1 copy of each chromosome
meiosis
phenotypes are produced by
metabolic pathways
1—> 2—> 3—>4—> Purple
Each arrow is an enzyme (protein)
Variation of a gene; same protein with slight differences, and a different sequence of nucleotides and amino acids
Allele
100-1000s of nucleotides make up a
gene
Spindle forms, homologs line up side by side in which meiosis I stage
Prophase I
Meiosis II stages:
Prophase II Metaphase II Anaphase II Telophase II Cytokinesis
When one allele dictates phenotype (A, B, C)
Dominant
Crossing over gives us
New combinations of alleles in gametes
M is:
Mitosis; DNA splits along with the cell
In which stage does the cell make proteins needed for division; cell grows to prep for M phase
G2
tumors that are non-harmful; doesn’t spread
benign
these are the same length with centromeres in the same place and contain the same genes
Homologs
aa genotype is
homozygous recessive
Alleles of an organism that determine phenotype
Genotype
Homologous chromosomes separate into different cells (diploid–> haploid) during
Meiosis I
Duplication of a chromosome is
not serious
the cell cycle happens in how many stages?
4: G1, S, G2, M
abnormal growth of cells
tumor
Chromosomes condense AGAIN in this meiosis stage
Prophase II
Deletion in a chromosome leads to
some abnormalities
Missing or extra chromosomes are:
Meiosis mistakes
gene mutation can lead to:
cancer
thousands of genes make up a
chromosome
Monosomy:
1 chromosome
DNA is _____ into mRNA
transcribed
In which stage does DNA replication begin and end?
A) G1
B) S
C) G2
S; DNA doubles and becomes a diploid cell
Stem cells:
Embryonic and adult
1 of 4 cells become an egg; other 3 disintegrate into polar bodies
Oogenesis
Change in diploid chromosome number
aneuploidy
where chromosomes are attached at a single point
Centromere
Genetic variation happens because of:
Meiosis
Sister chromatids split into different cells; 4 haploid cells produced
Meiosis II
Interphase consists of which stages
G1, S and G2
Parents are diploid, or 2_
2n
2 chromosomes of the same type
homologous chromosomes
trisomy is only viable on which chromosome
21
These are needed to evenly split the chromosomes into daughter cells
microtubules (spindle)
This stage results in 2 genetically identical daughter cells
Mitotic stage
Transitions between stages are also known as
Checkpoints
What are the 2 major stages of the cell cycle?
Interphase and Mitotic stage
______ alleles are masked by dominant alleles
recessive
DNA codes for a protein:
Gene
Proteins produce
Phenotypes
These inhibit the cell cycle and in inhibited can lead to cancer
Tumor suppressor genes
These adult ____ ____ transplants help a person recover from chemotherapy
stem cells
DNA genes/ allele combination (AA, Aa, aa)
Genotype
AA genotype is
homozygous dominant
segment of DNA that encodes protein
Gene
Cells grow larger, number of organelles double, and DNA is replicated before:
Each cell division
mRNA is _____ into proteins
translated
Inversion of a chromosome section is
ok, all genes are still present
Name the 2 stages of meiosis
Meiosis I and Meiosis II
Very long threads of DNA
chromosomes