Exam 3 Flashcards
What activates pain in inflammation?
Arachidonic acid triggers cox pathway which activates prostaglandin which activates the pain and inflammation
What can too much aspirin cause?
too much aspirin inhibits capillary permeability causing kidney impairment
What do Prostaglandins do?
Increase capillary permeability
Increase vasodilation
Increase pain and fever
Explain the difference between Non- selective and selective NSAIDS
non-selective targets both Cox 1 and 2 while selective targets just cox 2
What do corticosteroids end in?
-one and -lone
name the different classes of antigout drugs and their classes
Anitinflammatory-
-Colchicine (inhibits migration of leukocytes)
Uric acid Biosynthesis- ( inhibits the steps of uric acid)
- Alloporinol
- Febuxostat
Uricorsics( increase excretion of uric acid)
- Probenecid
- Sulfinpyrazone
What is Propionic acid
ibprofuen
What are the different classes of DMARD’s and their drugs
- Immunosuppressive: Azathioprine, cyclophosphamide, methotrexate
- Immunomodulatoes: Ankara, inflixmabetanercept
Non-selective have 6 subcategories name them and the drugs associated with them.
- ) Salicyate- Aspirin, diflunisal
- ) Propionic acid- Ibuprofen, naproxen
3) Phenylacetic acid- diclofenac, ketorolac - Parachlorobenzic acid- indomethacon
- ) Fenamate- meclofenamate
- ) oxicams- piroxicam, meloxicam
what is arthrotec?
difolfenac + misoprostol (arthritis+ stomach lining protection)
should you use propionic acid with warafarin?
no can cause increased bleeding.
What is the difference between immunosupressives and immunomodulators
immunomodulators inhibits proinflammatory agents, while immosupressives supresses your immune system
What are antimalarias
used to treat rheumatoid arthritis, take 4-12 weeks to work
