Chapter 2

Question 1

What is distribution?

Answer 1

Is a process of moving the drug from the blood stream to site of action

Question 2

What happens to bioavailabilty of a drug if there is a decreased liver function?

Answer 2

increased bioavailability of a drug, Less drug is destroyed by hepatic metabolism in the presence of liver disorder resulting in toxicity.

Question 3

Define Bioavailability

Answer 3

Is the % of the administered drug that reaches the systemic circulation

Question 4

IV adminstered dosages should be smaller or larger than other routes, why?

Answer 4

Smaller, because IV meds have a 100 % bioavailability

Question 5

What does Protein binding do to drugs?

Answer 5

decreases the concentration of free drug circulation

Question 6

What type of drug is able to diffuse into tissues?

Answer 6

free drug

Question 7

Name the common highly protein bound drugs

Answer 7

warfarin, ibuprofen, furosemide, diazepam

Question 8

Name the common weakly protein bound drugs

Answer 8

gentamicin, metformin, metoprolol , lisinopril

Question 9

What drugs cross easily in the blood bank barrier

Answer 9

lipid soluble

Question 10

what are teratogenic effects?

Answer 10

effects from the drug on developing fetus

Question 11

What is biotransformation?

Answer 11

Metabolism

Question 12

What do Liver diseases do drugs?

Answer 12

Slows metabolism, and prolongs effects

Question 13

If there is a liver disease or dystfunction which process will not take place, or not properly function

Answer 13

Metabolism

Question 14

Whats is CYP450?

Answer 14

a group of enzymes in the livers that break down the drug

Question 15

What is half life of a drug?

Answer 15

The time it takes for one half of the drug concentration to be eliminated

Question 16

Clearance is another word for?

Answer 16

Elimination or Excretion

Question 17

What tests are used to measure Kidney function ?

Answer 17

BUN and creatinine

Question 18

If the Urine is acidic what type of drugs are promoted to be excreted?

Answer 18

weak base drugs such as morphine

Question 19

If Urine is alkaline what type of drug is promoted to be excreted?

Answer 19

weak acid drugs such as asprin

Question 20

What does ED and LD stand for?

Answer 20

Effective dose, and Lethal Dose

Question 21

Define Agonists

Answer 21

Drug that has the ability to produce a desired therapeutic effect when bound to a receptor

Question 22

Define Anatgonists

Answer 22

Drugs that bind well to the receptor but produce no receptor response. This can prevent other drugs from having an effect this they are called blockers.

Question 23

What is the Loading dose?

Answer 23

A process by which the minimum effective concentration level when achieved in a short time. Giving a large initial dose to maintain minimum effective concentration