Exam 3 Flashcards
What are the distinguishing characteristics of muscles tissue?
- Excitability: outside stimuli initiate electrical change
- Contracity: stimuli leads to contractions
- Elasticity: muscles fibers are able to return to og shape
- Extensibility: muscle fibers need to stretch beyond relaxed length
What is the heirchy of the structure of muscles?
Muscles
Fascicles
Muscle Fibers
Myofibrils
Myofilaments
Actin & Mysin
What are Myofilaments?
- do not run entire length of muscle fibers
- organized in sarcomere (functional unit of contraction) - Short contractile proteins of two types:
1. thick (composed of myosin)
2. thin (composed of actin and associated proteins (tropomyosin and troponin)
What are Myofibrils?
Have the ability to shorten, resulting in contraction of the muscle and the production of motion
What is Epimysium?
dense CT that surrounds the entire muscle tissue
What is Sacrolemma?
plasma membrane that surrounds muscle fiber & regulate re-entry
What is a Sarcomere?
- functional unit of contraction
- defined by area between 2 adjacent Z discs
- each sarcomere shortens as the muscle fibers contract
- only H & I shorten (Hi)
What makes up skeletal muscle fibers?
- Attached to bone via tendon
- Multiple fasicles bundled together make up skeletal muscle
- contract and protect skeleton
- Muscle fibers have striations
- Skeletal Muscles are considered organs
- they are multinucleated
Nueron Junction?
What is the process of muscular contractions? What is the role of NT?
Muscle contraction begins with motor nuerons
1. Synaptic Knob: expanded end of the nueron
2. Synaptic Vesicles: membrane-bound vessicles filled w/ acetylcholine (ACh)
3. Motor end plate: region of sarcolemma across from synaptic knob that has folds and indentations to increase the surface area in that region
4. Synaptic cleft: narrow space seperating the synaptic knob from the motot end plate
5. ACh receptors: in the motor end plate that bind to ACh
6. Acetylcholinesterase: (AChE) an enzyme in the synaptic cleft that rapidly **breaks down **ACh
What is Hypertrophic Cartiomyopathy?
- excessive thickening of the heart muscle that inhibits the hearts ability to contract
- Myocardial disarray instead of normal muscle structure
What is Dilated Cardiomyopathy?
thinning and stretching of of heart muscle that cause it to grow larger
- dilated left ventricle
- loss of myocytes
- decrease in contractile proteins
- myofilament disarray
- interstitial fibrosis
What is CN VII paralysis?
- Facial nerve paralysis on the left side of the face
- lack of the left orbicularis oculi contraction
What is Strabismus?
- irregular eye alignment
- can be crossed eyes or walleyes
What is Torticollis?
- condition in which the neck muscles contract, causing the head to twist to one side
- happens in babies
What is Tetanus?
- a disease caused due to the action of toxin (tetanospasmin) produced by (Clostridium tetani) on synapses within the central nervous system
Symptoms: lockjaw and generalized muscle spasms risis sardonics= sardonic smile in older children and adults and opisthotonus=intense contraction of the paravertebral muscles in babies