Exam 3 Flashcards
what are the four functions of the respiratory system
- bring in oxygen and remove carbon dioxide
- sound production
- smell
- protection of airway via coughing and sneezing
what are the three types of respiration
ventilation, gas exchange, oxygen utilization by cells
what is ventilation
breathing (inhalation and exhalation)
what is gas exchange`
external and internal respiration
what does external respiration occur between
air and red blood cells in the lungs
where does the gas exchange occur in internal respiration
between red blood cells and the body tissues outside of the lungs
what are the two zones that the respiratory system is divided into
conducting zone
respiratory zone
what is the conducting zone
the respiratory passages that transport air
-filter out dust
-humidify and warm incoming air
what is the respiratory zone
site of gas exchange in the lungs
what are the structures of the conducting zone in order of passage of inhalation
nasal cavity
pharynx
larynx
trachea
main bronchi
lobar bronchi
segmental bronchi
bronchioles
terminal bronchioles
which structures of the conducting zone are closest to the respiratory zone
bronchioles and terminal bronchioles
what structures of the conducting zone are a part of the respiratory tree
main bronchi, lobar bronchi, segmental bronchi, bronchioles, terminal bronchioles
what structures are a part of the respiratory zone
respiratory bronchioles, alveolar ducts, alveoli
what is a cluster of alveoli called
alveolar sac
what kind of membrane are the lungs lines with
pleural membranes
what is the visceral pleura
the serous membrane surrounding the lungs
what is the parietal pleura
serous membrane lining the cavity
what two things are included in the parietal pleura
thoracic wall
mediasteum
what is located between the visceral and parietal pleura
pleural fluid
what is the purpose of pleural fluid
causes the lungs to inflate with breathing (vacuum)
what is a pneumothorax
when the negative pressure between the visceral and parietal pleura is broken and a lung collapses
what is pleural effusion
the accumulation of fluid in the pleural cavity
what are the support structures of the external nose
nasal bones, hyaline cartilage, dense CT
what are the three functions of the nose and nasal cavity
filter, warm, humidify air
smell
speech
where is the olfactory mucosa located
near roof of nasal cavity
what is housed in the olfactory mucosa
receptors for smell
what does the respiratory mucosa line
most of the respiratory passageway
-opens to outside of body
what kind of epithelium is the respiratory mucosa
pseudostratified ciliated columnar epithelium
what kind of cells are in the respiratory mucosa to produce mucus
goblet cells
what is underlying the epithelium in the respiratory mucosa
lamina propria
what two kinds of cells are in the underlying lamina propria of the respiratory mucosa
mucus cells: secrete mucus
serous cells: secrete digestive enzyme
what is the reason for the lamina propria of the respiratory mucosa being so vascular
to warm air
what two things make up the mucous membrane
pseudostratified ciliated columnar epithelium
lamina propria
why does the respiratory mucosa have sticky mucus
to trap pathogens and debris
what is the mucociliary escalator referring to
the cilia constantly moving sheets of mucus to posterior region of nasal cavity
what happens to cilia when it is cold
the cold air slows the cilia down
where are the external nares and vestibule located
the opening to the nasal cavity
what are the external nares and vestibule lined with
vibrissae (protective hairs)
what are the nasal conchae
bony ridges that create air turbulance
why does the nasal conchae need to create air turbulance
to fling pathogens onto mucus lined epithelium and warm the air
where are the olfactory receptor cells located
passing through the cribriform plate onto the olfactory mucosa
how is smell created
odorants bind to the receptors on the olfactory receptor cells
where does the nasal cavity end
posterior nasal aperture
what are paranasal sinuses
air filled cavities in bone
what are the two main functions of the sinuses
lighten the skull
warm/moisten the air
how many openings into the nasal cavity do the sinuses have
one
what kind of epithelium are the sinuses lined with
pseudostratified ciliated columnar epithelium
what are the four paranasal sinuses
frontal
ethmoid
sphenoid
maxillary
where is the frontal sinus located
right above eyes
where are the ethmoid sinuses located
between eyes more forward than sigmoid
where are the sigmoid sinuses located
between eyes but further back where the pituitary gland starts
where are the maxillary sinuses located
next to nose (cheeks)
what does the nasal meatus contain
an opening for sinus into nasal cavity
what is a sinus infection
inflammation of epithelium caused by virus or bacteria
what happens to the meatus with a sinus infection
it becomes blocked
what is a nasal septum
bone and cartilage that separates nasal cavity in half
what is a deviated septum
when the cartilage separating the nasal cavity becomes misaligned
what happens to the air flow with a deviated septum
it is disrupted
what are the three sections of the pharynx
nasopharynx, oropharynx, laryngopharynx
what section is the nasopharynx
posterior nares to soft palate
what section is the oropharynx
soft palate to epiglottis
what section is the laryngopharynx
epiglottis to superior esophagus
which regions of the pharynx have passage of food and liquid
oropharynx and laryngopharynx
what kind of epithelium makes up the nasopharynx
pseudostratified ciliated columnar
what primarily passes through the nasopharynx
air
what kind of epithelium makes up the oropharynx
stratified squamous
what primarily passes through the oropharynx
food and air
what kind of epithelium makes up the laryngopharynx
stratified squamous
what primarily passes through the laryngopharynx
food and air
what are the pharyngeal tonsils
lymphoid tissue in the nasopharynx
what is the pharyngotympanic tube
connects to middle ear
what closes off the nasopharynx during swallowing to prevent food from moving into the nasal cavity
uvula
what are the palatine tonsils
the tonsils that are more superior
what are the lingual tonsils
tonsils that are more inferior and are located at back of the tongue
what is tonsillitis
inflammation of palatine tonsils
what is connected by the laryngopharynx
pharynx with openings to larynx (air) and esophagus (food)
what kind of cartilage is the epiglottis made of
elastic cartilage
what does the epiglottis cover
the larynx when swallowing food
what type of cartilage is thyroid cartilage
hyaline cartilage
what is attached to the thyroid cartilage
attachment site for vocal folds
what kind of cartilage is the cricoid cartilage
hyaline
where is the cricoid cartilage located
under the thyroid cartilage
what kind of cartilage is arytenoid cartilage
hyaline
what does the arytenoid cartilage do
anchors vocal folds posteriorly
what are the vocal folds
true vocal cords; actually vibrate and make sound
what are the vocal folds made of
elastic fibers covered with mucosa
what are the vocal folds suspended between
thyroid and arytenoid cartilages
what happens to the vocal folds as air passes over
they vibrate
why do males have deeper voices
the vocal folds are longer so the vibrations are slower
what are vestibular folds
false vocal cords
what are the vestibular folds made of
folds of mucosa that support vocal folds
what is the rima glottidis
space between open vocal folds
what is the glottis
vocal folds and rima glottidis
what creates sound
the vibrations of vocal folds as air moves past them
what creates a higher pitch
longer and thinner vocal fold
what 4 structures contribute to making sound
pharynx, nasal cavity, oral cavity, sinuses
as you breathe in air, what happens to vocal folds
they move apart
as air moves through the vocal folds, what happens to them
they close
what is laryngitis
excess mucus and inflammation prevent proper vibration of vocal folds
what were castrati (1600s-1800s)
male sopranos
castrated before puberty
lower testosterone levels
larynx does not enlarge
what does the trachea connect
larynx and lungs
what kind of epithelium is in the trachea
pseudostratified ciliated columnar epithelium
does the trachea contain goblet cells
yes
what kind of rings make up the trachea
hyaline cartilage rings
what are the hyaline cartilage rings in the trachea joined by
fibroelastic CT
what shape are the rings in the trachea
C shaped
what is the purpose of the rings of the trachea
to keep tracheal lumen open when we swallow food
what are the two specialized mucus-secreting structures in the trachea
goblet cells - epithelium
seromucous glands - submucosa
what are the effects of smoking on cilia
they can be paralyzed or destroyed by toxins in cigarette smoke
what is the path in which cilia moves mucus away from lungs
up (away from lungs) then down (into esophagus)
what surrounds the lumen of the trachea
mucous membrane
what layer of the trachea is under the mucous membrane
submucosa with seromucous glands
what kind of cartilage makes up the trachea
hyaline cartilage
what is the covering of the trachea called
adventitia
what is the trachealis muscle
smooth muscle that completes posterior of trachea
what is the carina
last ring of tracheal cartilage
what happens at the carina of the trachea
the trachea branches into left and right main bronchi
what initiates the cough reflex
the carina of the trachea has epithelial cells that are very sensitive to irritants and excess mucus
what are the 4 segments of the bronchial tree
main (primary) bronchi - 1 per lung
lobar (secondary) bronchi - 1 per lobe
segmental (tertiary) bronchi - 1 per bronchopulmonary segment
bronchioles
do the bronchioles have cartilage
no
what happens to the cartilage rings in the main primary bronchi
they are replaced by irregular cartilage plates
what kind of epithelium makes up the main bronchi
pseudostratified ciliated columnar epithelium
what is the difference between the right and left bronchus
the right bronchus is wider, shorter, and more vertical than the left
which bronchus do inhaled substances usually enter
the right primary bronchus
how many lobes does the right lung have
3 lobes
how many lobar bronchi does the right lung have
3
how many lobes does the lobar bronchus serve
1 lobe
how many lobes does the left lung have
2 lobes
how many lobar bronchi does the left lung have
2
what does the segmental bronchus serve
the bronchopulmonary segment
what are the lobes divided into
segments
can segments of the lungs function independently of other segments
yes
if one segment is diseased, will it move to other segments
no
how do the lungs regulate air flow
the smooth muscle contracts and relaxes
is smooth muscle present around the alveoli
no
what is the cartilage transition as you go down the pulmonary airway tree
regular plates (bronchi open) –> irregular plates (won’t stay open as regularly) –> no cartilage (broncho-constriction)
what can lead to broncho-constriction
if there is smooth muscle and no cartilage
what is the epithelium transition as you go down the pulmonary airway tree
pseudostratified ciliated columnar –> simple columnar –> simple cuboidal –> simple squamous
what are the two phases of bronchial asthma
early phase and late phase
what are the steps of the early phase of bronchial asthma
- allergens, cold air, etc cause mast cells to release inflammatory chemicals
- contraction of bronchial smooth muscle (bronchoconstriction)
- increase in mucus secretion in airways
what are the steps of the late phase of bronchial asthma
- white blood cells accumulate in bronchi and bronchioles
- inflammatory chemicals are released
- mucosa is damaged
- increased release of mucus
- bronchoconstriction is increased
what are the two treatments for bronchial asthma
bronchodilators
anti-inflammatories
what happens in the respiratory zone
external gas exchange
what does the epithelium switch (from –> to) in the respiratory zone
simple cuboidal to simple squamous
what are the 4 structures of the respiratory zone
respiratory bronchioles
alveolar duct
alveoli
alveolar sac (alveolar duct and alveoli)
what is the alveolar sac
cluster of alveoli on a duct
what do alveoli do for the lungs
increase the volume of lungs and surface area for gas exchange
what surrounds the alveoli
capillary network
what type of cells are type I alveolar cells
flat cells, simple squamous epithelium, part of respiratory membrane
what type of cells are type II alveolar cells
cuboidal cells, not part of respiratory membrane
where does gas exchange occur in the respiratory zone
across the respiratory membrane
what is contained in the respiratory membrane
alveolar epithelium + capillary epithelium + fused basement membranes of both epithelia
what type of epithelium is alveolar epithelium
simple squamous
what type of epithelium is capillary epithelium
simple squamous
what do type II cells secrete
surfactant
what does surfactant do to the alveoli
decrease surface tension and allows alveoli to inflate more easily
what do macrophages do
phagocytize inhaled particles (get rid of bad things in the lungs)
what do the alveolar pores do
equalize the pressure between alveoli
what is a lobule
1 larger bronchiole and all of its branches
what is the shape of a lung lobule
hexagonal
what is the stroma
elastic CT that surrounds lobules
what happens to the diaphragm with inspiration
it moves inferiorly (down) as it contracts
what happens to the ribs and sternum with inspiration
the ribs elevate and the sternum flares as external intercostals contract to create room
what happens to the thoracic volume with inspiration
it increases
what happens to the air pressure in the lungs with inspiration
it decreases
what happens to the diaphragm with expiration
it moves superiorly (up) as it relaxes
what happens to the ribs and sternum with expiration
they depress as the external intercostals relax
what happens to the thoracic volume with expiration
it decreases
what happens to the air pressure in the lungs with expiration
it increases
is inspiration an active or passive process
active (requires ATP)
is expiration an active or passive process
passive (no ATP/energy required)
what type of cells are not fully functional until ~35 weeks of development
type II cells
why do premature infants have difficulty inflating collapsed alveoli
insufficient production of surfactant
what is the primary cause of lung cancer
smoking
what does smoking damage
the cilia
increased mucus production
depresses lungs macrophages
what is the most effective treatment for lung cancer
removal of diseased tissue
what is COPD
flow of air into and out of lungs is difficult or obstructed
what are the two types of COPD
chronic bronchitis
emphysema
what are the indications for chronic bronchitis
increased mucus secretion, inflammation, formation of scar tissue
what is dyspnea
labored or difficult breathing
what does emphysema mean
to inflate
what causes permanent enlargement of alveoli
alveolar walls are destroyed by lysosomal enzymes produced by macrophages
what does fibrosis (scarring) of lungs cause
difficulty with expiration
what are COPD patients referred to as
blue bloater
what are emphysema patients referred to as
pink puffer
what are the three components of the cardiovascular system
heart
blood vessels
blood
what do the components of a cardiac muscle cell resemble
skeletal muscle cell
how many nuclei does a cardiac muscle cell have
one
is cardiac muscle branched
yes
what are two different things that cardiac muscle cells can do
- contract
- conduct an impulse
what is an intercalated disc made of
gap junctions and desmosomes
what is the purpose of the gap junction in an intercalated disc
allows for quick communication between cells for coordinated contraction
what is the purpose of the desmosome in an intercalated disc
distribute the tension when the cells contract
what is another name for a desmosome in an intercalated disc
fascia adheren
what is the function of the heart
pumps blood
what is the function of the arteries
carry blood away from heart
what is the function of the veins
carry blood toward heart
what is the function of blood
transports nutrients, wastes, etc
what is the pulmonary circuit
the route between the heart and lungs
what does the pulmonary circuit allow the blood to do
pick up oxygen
what is the order of the pulmonary circuit
right ventricle –> pulmonary trunk –> pulmonary arteries –> lungs –> pulmonary veins –> left atrium
where does the gas exchange occur in the lungs
capillary beds
what is the systematic circuit
route between the heart and the body tissues
what is the purpose of the systematic circuit
brings oxygen to the cells
what is the order of the systematic circuit
left ventricle –> aorta –> cells of body –> veins –> right atrium
what are the four distinct chambers of the heart
right atrium, right ventricle, left atrium, left ventricle
what is the pericardium
a triple layered sac that encloses the heart
what is the outer layer of the pericardium called
fibrous pericardium
what is the inner layer of the pericardium called
serous pericardium
what are the 2 main functions of the fibrous pericardium
anchors heart
prevents overfilling
what is the fibrous pericardium made of
dense irregular CT
what is the heart wall made of
closest to heart
epicardium (serous layer of pericardium)
myocardium (muscle)
endocardium
heart chamber
the serous pericardium is made of what 3 things
visceral pericardium
pericardial cavity
parietal pericardium
what is the purpose of the pericardial cavity
to reduce friction between contracting heart and outer wall of pericardial sac
what is the pericardial cavity filled with
pericardial fluid
what is cardiac tamponade
aka pericardial effusion
occurs when there is excess pericardial fluid
what is the epicardium
visceral pericardium
what is the myocardium
cardiac muscle tissue
what is the endocardium made of
simple squamous epithelium
why is the endocardium made of simple squamous epithelium
so that blood will move smoothly through the heart
which side of the heart has high O2
left
which side of the heart has low O2
right
does the superior vena cava have O2? where is it coming from?
low O2
coming from upper part of body
does the pulmonary trunk have high or low O2
low O2
what is the pulmonary trunk connecting
the heart to the lungs
blood heart –> lungs
does the inferior vena cava have O2? where is it coming from?
low O2
coming from lower part of body
do the pulmonary arteries have O2
low O2
have not been to lungs yet
do the pulmonary veins have O2
high O2
coming to the heart from the lungs
what are papillary muscles
projections of cardiac muscle in both ventricles
what are papillary muscles attached to
atrioventricular valves
how are papillary muscles attached to atrioventricular valves
chordae tendineae
what is chordae tendineae made out of
dense regular CT
which ventricle has a thicker myocardium
left
why does the left ventricle have a thicker myocardium
it pumps blood to the entire body