Exam 2 Flashcards
what are the functions of muscle contraction
allow material to move through the body
allow parts of the body to move
generation of heat
what are the different types of muscle tissue
skeletal, cardiac, smooth
what does the skeletal muscle do
moves the skeleton under voluntary control
is skeletal muscle multinucleated? is it striated?
yes
yes
what is another term for muscle cell
muscle fiber
where is cardiac muscle found
in the heart wall
how many nuclei does cardiac muscle have? is it striated?
one nucleus per cell
yes, it is striated
are cardiac and smooth muscle under voluntary or involuntary control
involuntary
where is smooth muscle found
in the walls of hollow organs
how many nuclei does smooth muscle have? is it striated?
it has one nucleus per cell
no striations
what are the properties of muscle tissue
excitability
contractility
extensibility
elasticity
what does excitability mean in relation to the properties of muscle tissue
nerve signal excites the muscle, causing a contraction
what does contractility mean in relation to the properties of muscle tissue
when a muscle contracts, it shortens
-occurs at a microscopic level as myofilaments pull past each other
what does extensibility mean in relation to the properties of muscle tissue
after contraction, the muscle can go back to resting length (by gravity or an antagonist)
what does elasticity mean in relation to the properties of muscle tissue
after being stretched, a muscle recoils passively and resumes its resting length
-when muscle is stretched beyond its resting length, it can return to its resting length (titin)
what do arteries provide to muscle cell
provide oxygen and nutrients
what do veins do for the muscle cell
remove cellular wastes
what do nerves do in a muscle cell
innervate the muscle cell
what are the subunits of the WHOLE muscle called
fascicles
what are fascicles made of
individual muscle fibers (muscle cells)
what does the epimysium surround?
the whole muscle
what is the epimysium made of
dense irregular CT
what does the perimysium surround
fascicles
what is the perimysium made of
fibrous CT
what does the endomysium surround
individual muscle fibers
what is the endomysium made of
loose CT
what are individual muscle fibers (muscle cells) made of
myofibrils
what are myofibrils made of
sarcomeres
what are sarcomeres made of
proteins called myofilaments
what gives skeletal muscle its striated appearance
the sarcomeres
what are the boundaries of the sarcomere called
z-disc
what are the two different myofilaments
thick filament and thin filament
what is the thick filament made of
myosin
what is the thin filament made of
actin, troponin, tropomyosin
what is the myosin anchored to
the M line
what is the actin anchored to
the z line
what is the elastic filament
titin that attaches the z disc to the thick filament
-provides elasticity
what binds to the active site during muscle contraction
the myosin head
how do myosin heads cause muscle contraction
they use leverage to move the thin (actin) filaments inward
which protein blocks the active sites in muscle contraction
tropomyosin
how does the actin binding site become unblocked
Ca2+ binds to troponin which causes tropomyosin to unblock the binding site
which does not change with contraction?
-I band
-H zone
-A band
-Z disc
the A band does not change length with contraction
what is the A band? what will it include?
the length of the thick filament (myosin)
-will include thick and thin filaments
what is the H zone? what will it include?
the area between thin filaments (actin) within a single sarcomere
-will include only thick filaments
does the H zone change size with contraction
the H zone gets smaller with contraction
-it can disappear completely with full contraction
what is the I band? what will it include?
the area between 2 thick filaments of adjacent sarcomeres
-will include the Z disc, thin filament, elastic filament
does the I band change length with contraction
it gets shorter with contraction but cannot completely disappear because of the elastic filament
what is the M line
the middle of the H zone
-filaments hold thick filament (myosin) in place
what is the sarcolemma
the plasma membrane of a muscle fiber
what is the sarcoplasm
the cytoplasm of the muscle fiber
what direction to myofibrils run in relation to the muscle fibers
parallel to each other and the muscle fiber
what are t tubules
extensions of the sarcolemma that extend into muscle fiber
what do the t tubules wrap around
myofibrils
what do t tubules do for the muscle cell
carry electrical stimulus to the myofibrils
where is Ca2+ stored in the muscle
sarcoplasmic reticulum
what is the sarcoplasmic reticulum? what does it do?
modified smooth ER
-stores and releases calcium ions
what is the sliding filament theory
during a contraction, actin and myosin myofilaments slide over each other
-thin slide over thick
what is a motor unit
1 motor neuron and all the muscle fibers it innervates
what causes a larger/stronger contraction
more muscle fibers are stimulated
what is the neuromuscular junction
where a motor neuron meets a muscle fiber
what occurs at the neuromuscular junction
stimulation of the muscle fiber
what does the motor neuron release to start an action potential
ACh
when the action potential travels down the T tubule, what is released
Ca2+ from the sarcoplasmic reticulum
how does an action potential of a muscle occur
ACh is released from vesicles in the axon terminal by exocytosis
- this ACh binds to receptors that open channels to trigger the action potential
what does the action potential ultimately cause
sarcomere shortening
how are muscle fibers arranged
in a pattern that provides the most efficient movement for an extended action
what does muscle power depend on
the total number of muscle fibers in the muscle
-more fibers –> stronger contraction
how much is each muscle fiber able to shorten
to about 1/3 of its resting length
-longer muscle fibers are able to shorten more than short muscle fibers
which muscle would you expect to shorten the most during a contraction
the one with the longest fibers
which muscle would you expect to apply the most force during a contraction
the one with the largest amount of muscle fibers
what are the different fascicle arrangements in muscles
parallel
pennate
convergent
circular
which direction do parallel muscles run in
parallel to the axis of the muscle
what is on either end of parallel muscles
tendons
do parallel muscles have more or less fibers than other types
fewer fibers
do parallel muscles have long or short fibers
long
what is the major characteristic of pennate muscles
the tendon runs the whole length of the muscle
how and where to the fascicles attach in a pennate muscle
attach to the tendon at an angle (feather-like)
do pennate muscles have longer or shorter fibers
shorter fibers
do pennate muscles have more or less fibers than parallel muscles
more fibers
what is the main characteristic of convergent muscles
the origin of the muscle is broad (ex. pectoralis major)
where do the fascicles converge in a convergent muscle
converge into a tendon at the insertion
what are convergent muscles shaped like
a fan
do convergent muscles have more or less fibers than parallel muscles
more fibers
do convergent muscles have longer or shorter fibers than pennate
longer fibers
which type of muscle arrangement is the weakest
parallel (few muscle fibers)
which type of muscle arrangement is the strongest
pennate (most muscle fibers)
which type of muscle arrangement can shorten the least
pennate (shortest muscle fibers)
which type of muscle arrangement can shorten the most
parallel (longer muscle fibers)
how are the fascicles shaped in circular muscles
arranged in a ring
what muscles are circular muscles
sphincter muscles
what happens to circular muscles when contracted
the muscle constricts an orifice (opening), closing it
what is the origin of a muscle
attachment site that is not moved, or is moved the least during a muscle contraction
what is the insertion of a muscle
the attachment site that is moved when a muscle shortens
what is the action of a muscle
the resulting movement of a muscle contraction
what are tendons continuous with
the periosteum of bones
what CT does the direct muscle attachment use? what is it connecting?
short, dense regular CT fibers connect origin of muscle to bone
what CT does the indirect muscle attachment use? what is it connecting?
long, dense regular CT fibers connect insertion of muscle to bone
what are examples of indirect muscle attachments
tendons and aponeuroses
what is the aponeuroses
flat sheet of muscle (external oblique)
what is visible on the bone where muscles attach
raised bone markings
what causes an increase in muscle strength and size
with injury (during exercise) satellite cells fuse with muscle fibers and proliferate
-the new satellite cells produce proteins that help repair the damages muscle fibers
do skeletal muscle cells divide
no
what are satellite cells
stem cells, immature cells that resemble undifferentiated myoblasts
what happens if there is too severe of an injury to the skeletal muscle cells
muscle cells will be replaced by scar tissue
what are some characteristics of cardiac muscle (is it striated, multinucleated, voluntary or involuntary)
striated, branched, uninucleate, involuntary control
do cardiac muscle cells have regenerative ability
some, ~1% a year
what are cardiac muscle cells surrounded by
endomysium
what are cardiac muscle cells connected by
intercalated discs
what is an intercalated disc made of
gap junctions and desmosomes
what is the role of gap junctions in intercalated discs
allow for coordinated contractions by allowing action potentials to quickly spread from cell to cell
what is the role of desmosomes in intercalated discs
provide strength
site where intermediate filaments attach
what is the inherent rhythmicity of cardiac muscle
cardiac muscle cells are able to initiate their own contraction without stimulation from the nervous system
what are smooth muscle cells shaped like
small, spindle shaped cells
how many nuclei do smooth muscle cells have
uninucleate (one)
are smooth muscle cells striated
no
do smooth muscle cells contain myofilaments
yes but they are not arranged in sarcomeres
what covers the smooth muscle cell
endomysium
do smooth muscle cells have a regenerative capacity
yes
what anchors actin and myosin in a smooth muscle cell
intermediate filaments
what does a contraction in a smooth muscle cell consist of
myosin and actin filaments moving against one another
how is smooth muscle typically arranged
in two distinct layers
what are the two distinct layers that smooth muscle cells are arranged in
circular layer
longitudinal layer
what is the circular layer in a smooth muscle cell
the layer closest to the lumen of the organ
what is the longitudinal layer in a smooth muscle cell
the layer that wraps around the circular layer
what is the typical orientation of cells in the layers of smooth muscle
typically perpendicular to each other
what is mobility
the amount of movement at a joint
what is mobility dependent on
the type of materials joining the bones and the articulating surfaces of the bones
what are the three types of joint classification based on mobilty
synarthrosis
amphiarthrosis
diarthrosis
what is synarthrosis
immobile, mostly axial
what is amphiarthrosis
slightly moveable, mostly axial
diarthrosis
freely movable, mostly appendicular
what are the three joint classifications based on joint structure
fibrous
cartilaginous
synovial
what is the structural classification of joints based on
the type of material that binds the bones together and whether or not there is a joint cavity
what are the characteristics of a fibrous joint
no joint cavity
dense regular CT connects bones
what are the characteristics of a cartilaginous joint
no joint cavity
cartilage connects bones
what are the characteristics of a synovial joint
yes joint cavity
ligaments and articular capsule connect bones
ends of bones covered with articular cartilage (hyaline)
what is a suture
fibrous joint is held together by short, interconnecting fibers
bone edges interlock
where are sutures found
between bones of the skull
what are sutures connected with
short dense regular CT fibers
what does synarthrotic mean
bones do not move independently
what is the reason for sutures in the skull
allow for skull growth
when do skull bones fuse together
during middle age
what are syndesmoses
fibrous joints where the joint is held together by a ligament
what does syndesmoses mean
with ligament
what does amphiarthrotic mean
a small amount of movement
(longer fibers=more movement)
what are syndesmoses made of
dense regular CT
-longer than sutures
where are syndesmoses usually found
between long bones
what is a gomphosis
peg-in-socket fibrous joint
where are gomphoses found
in teeth
-attach tooth to bone of socket
what are the types of fibrous joints
sutures
syndesmoses
gomphoses
what are the types of cartilaginous joints
synchondroses
symphyses
what is a synchondroses
a cartilaginous joint where bones are united by hyaline cartilage
do synchondroses move
no, they are synarthrotic
where are synchondroses found
epiphyseal plates
between first rib’s costal cartilage and sternum
what are symphyses
cartilaginous joint where the bones are united by fibrocartilage
can symphyses move
amphiarthrotic: small amount of movement
what are bones united by in a symphyses joint
fibrocartilage pad
where are symphyses joints found
intervertebral disc
pubic symphysis
do synovial joints move
yes, they are diarthrotic (freely movable)
what are the three things that synovial joints have
ligaments
joint cavity
articular capsule (joint capsule)
what do ligaments connect
bone to bone
what are ligaments made of
dense regular CT
what is the joint cavity
potential space with small amount of synovial fluid
what protects the synovial fluid
the synovial membrane
what is the articular capsule
the outer fibrous layer and the inner synovial membrane
what is the fibrous layer of the articular capsule made of? what is it continuous with?
dense irregular CT
continuous with the periosteum
what is the synovial membrane of the articular capsule? what is it made of?
the inner lining of the capsule and all other internal joint surfaces not covered in cartilage
loose CT
is the synovial membrane vascular
yes
what does the synovial membrane produce
synovial fluid
what is synovial fluid
blood filtrate
acts as a lubricant within the capsule
what makes the synovial fluid slippery
glycoproteins