Exam 2 - Viral Hepatitis Flashcards

1
Q

Name the five major immunoglobulins.

A

1) IgM
2) IgG
3) IgA
4) IgD
5) IgE

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2
Q

What are the signs of hepatitis in a clinical presentation?

A
  • Elevated aminotransferases (AST, ALT, Alk Phos)
  • Hyperbilirubemia
  • Hypoalbuminemia
  • Hypoprothrombinemia
  • Hepatomegaly
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3
Q

What is the ULN of ALT for men?

A

35 U/L for men

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4
Q

What is the ULN of ALT for women?

A

25 U/L for women

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5
Q

What are the symptoms for hepatitis in clinical presentation?

A
  • Constitutional (fatigue, malaise, anorexia, nausea, myalgia, arthralgia, HA)
  • Icterus
  • RUQ abdominal pain
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6
Q

Name the 3 major hepatitis complications.

A

1) Liver failure
2) Cirrhosis
3) Hepatocellular carcinoma

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7
Q

What are the 3 things for diagnosis of liver failure in hepatitis?

A

1) Elevated AST/ALT
2) Hepatic encephalopathy
3) Prolonged prothrombin time (>1.5)

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8
Q

Name the 6 complications of cirrhosis that classify the condition as Decompensated Cirrhosis.

A

1) Ascites
2) Variceal hemorrhage
3) Spontaneous bacterial peritonitis
4) Hepatic encephalopathy
5) Hepatorenal syndrome
6) Hepatopulmonary syndrome

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9
Q

HAV stands for?

A

Hepatitis A Virus

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10
Q

How is HAV transmitted?

A

Oral-fecal route

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11
Q

What is the incubation period for HAV?

A

28 days

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12
Q

Which hepatitis virus is associated with low socioeconomic status, poor sanitary conditions, and dense population?

A

HAV

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13
Q

T/F: Infection with Hep A confers lifelong immunity.

A

TRUE

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14
Q

Describe the serologic response to HAV infection.

A
  • Jaundice
  • Increased ALT
  • Fecal HAV
  • IgM Anti-HAV
  • IgG Anti-HAV
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15
Q

How long do symptoms of HAV last?

A

Generally 2 months

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16
Q

What are the symptoms of HAV?

A

Similar to other forms of Hepatitis

17
Q

What is required for HAV diagnosis?

A
  • Elevated ALT
  • Presence of IgM antibodies directed against HAV (IgM anti-HAV) = ACUTE infection
  • IgG antibodies against HAV (IgG anti-HAV) suggest immunity = previous infection or vaccination
18
Q

What is the only recommended treatment for HAV?

A

SUPPORTIVE CARE

19
Q

Is vaccination recommended after acute HAV?

A

NO - infection confers lifelong immunity

20
Q

T/F: Supportive care is the only recommended treatment for Hepatitis A Virus infections.

A

TRUE

21
Q

T/F: Immune globulin administration (GamaSTAN) is not recommended in HAV.

A

TRUE