Exam 2: Uptake / Distribution of Inhalation Agents Flashcards
Uptake =
ƛ * Q * (A-v)
Solubility * CO * difference in alveolar/venous partial pressures
For IAs, blood is an:
inactive reservoir
Higher blood-gas coefficient means:
Agent is more soluble
More agent in blood = less in alveoli/brain
Another name for blood-gas partition coefficient:
Oswaldt Solubility Coefficient
Brain-level activity of a highly vs. minimally soluble IA:
Highly soluble: low brain activity
Minimally soluble: high brain activity
Effect of solubility on induction and emergence:
Less soluble = faster induction/emergence
More soluble = slower induction/emergence
Five partial pressure gradients between vaporizer and end-target tissue:
Vaporizer and inflow Inflow and circuit Circuit and alveoli Alveoli and blood Blood and tissues
Impact of HCT on B/G coefficient:
↓ HCT = ↓ B/G coefficient
Dropping HCT from 21 –> 43 drops B/G coefficient by 20%
D/t less binding sites in the blood
FA vs. FI:
FA = alveolar concentration FI = inspired concentration
FD = FI when:
High flow rate with no re-breathing
Make these changes to ventilation to ↑ uptake:
↓ TV, ↑ rate
PA of volatile anesthetic is determined by (4):
PI (inhaled partial pressure)
Alveolar ventilation
Breathing circuit
FRC
Normal VA:
4L/min
Solubility’s effect on the rate at which FA approaches FI:
Least soluble = fastest rate of matching FA to FI
Describe the FA/FI curve:
First rise: VRG uptake First knee: VRG at equilibrium Second rise: MG uptake Second knee: MG at equilibrium Third rise: FG/VPG uptake (very slow)