Exam 1: Opioid Pharmacokinetics Flashcards
1
Q
pK of morphine:
A
7.9
2
Q
% nonionized (pH 7.4) of morphine:
A
23%
3
Q
Pb of morphine:
A
35%
4
Q
Clearance of morphine:
A
1,050 mL/min
5
Q
Vd of morphine:
A
224 L
6
Q
Partition coefficient of morphine:
A
1
7
Q
Et1/2 of morphine:
A
1.7 - 3.3 hrs
8
Q
pK of meperidine:
A
8.5
9
Q
% nonionized (pH 7.4) of meperidine:
A
7%
10
Q
Pb of meperidine:
A
70%
11
Q
Clearance of meperidine:
A
1,020 mL/min
12
Q
Vd of meperidine:
A
305 L
13
Q
Partition coefficient of meperidine:
A
32
14
Q
Et1/2 of meperidine:
A
3 - 5 hrs
15
Q
pK of fentanyl:
A
8.4
16
Q
% nonionized (pH 7.4) of fentanyl:
A
8.5%
17
Q
Pb of fentanyl:
A
84%
18
Q
Clearance of fentanyl:
A
1,530 mL/min
19
Q
Vd of fentanyl:
A
335 L
20
Q
Partition coefficient of fentanyl:
A
955
21
Q
Et1/2 of fentanyl:
A
3.1 - 6.6 hrs
22
Q
Context sensitive t1/2 (4 hr infusion) of fentanyl:
A
260 min
23
Q
Effect-site equilibration time of fentanyl:
A
6.8 min
24
Q
pK of sufentanil:
A
8.0
25
% nonionized (pH 7.4) of sufentanil:
20%
26
Pb of sufentanil:
93%
27
Clearance of sufentanil:
900 mL/min
28
Vd of sufentanil:
123 L
29
Partition coefficient of sufentanil:
1,727
30
Et1/2 of sufentanil:
2.2 - 4.6 hrs
31
Context sensitive t1/2 (4 hr infusion) of sufentanil:
30 min
32
Effect-site equilibration time of sufentanil:
6.2 min
33
pK of alfentanil:
6.5
34
% nonionized (pH 7.4) of alfentanil:
89%
35
Pb of alfentanil:
92%
36
Clearance of alfentanil:
238 mL/min
37
Vd of alfentanil:
27 L
38
Partition coefficient of alfentanil:
129
39
Et1/2 of alfentanil:
1.4 - 1.5 hrs
40
Context sensitive t1/2 (4 hr infusion) of alfentanil:
60 min
41
Effect-site equilibration time of alfentanil:
1.4 min
42
pK of remifentanil:
7.3
43
% nonionized (pH 7.4) of remifentanil:
58%
44
Pb of remifentanil:
66 - 93%
45
Clearance of remifentanil:
4,000 mL/min
46
Vd of remifentanil:
30 L
47
Et1/2 of remifentanil:
0.17 - 0.33 hrs
48
Context sensitive t1/2 (4 hr infusion) of remifentanil:
4 min
49
Effect-site equilibration time of remifentanil:
1.1 min
