Exam 1: Opioid Pharmacokinetics

Question 1

pK of morphine:

Answer 1

7.9

Question 2

% nonionized (pH 7.4) of morphine:

Answer 2

23%

Question 3

Pb of morphine:

Answer 3

35%

Question 4

Clearance of morphine:

Answer 4

1,050 mL/min

Question 5

Vd of morphine:

Answer 5

224 L

Question 6

Partition coefficient of morphine:

Answer 6

1

Question 7

Et1/2 of morphine:

Answer 7

1.7 - 3.3 hrs

Question 8

pK of meperidine:

Answer 8

8.5

Question 9

% nonionized (pH 7.4) of meperidine:

Answer 9

7%

Question 10

Pb of meperidine:

Answer 10

70%

Question 11

Clearance of meperidine:

Answer 11

1,020 mL/min

Question 12

Vd of meperidine:

Answer 12

305 L

Question 13

Partition coefficient of meperidine:

Answer 13

32

Question 14

Et1/2 of meperidine:

Answer 14

3 - 5 hrs

Question 15

pK of fentanyl:

Answer 15

8.4

Question 16

% nonionized (pH 7.4) of fentanyl:

Answer 16

8.5%

Question 17

Pb of fentanyl:

Answer 17

84%

Question 18

Clearance of fentanyl:

Answer 18

1,530 mL/min

Question 19

Vd of fentanyl:

Answer 19

335 L

Question 20

Partition coefficient of fentanyl:

Answer 20

955

Question 21

Et1/2 of fentanyl:

Answer 21

3.1 - 6.6 hrs

Question 22

Context sensitive t1/2 (4 hr infusion) of fentanyl:

Answer 22

260 min

Question 23

Effect-site equilibration time of fentanyl:

Answer 23

6.8 min

Question 24

pK of sufentanil:

Answer 24

8.0

Question 25

% nonionized (pH 7.4) of sufentanil:

Answer 25

20%

Question 26

Pb of sufentanil:

Answer 26

93%

Question 27

Clearance of sufentanil:

Answer 27

900 mL/min

Question 28

Vd of sufentanil:

Answer 28

123 L

Question 29

Partition coefficient of sufentanil:

Answer 29

1,727

Question 30

Et1/2 of sufentanil:

Answer 30

2.2 - 4.6 hrs

Question 31

Context sensitive t1/2 (4 hr infusion) of sufentanil:

Answer 31

30 min

Question 32

Effect-site equilibration time of sufentanil:

Answer 32

6.2 min

Question 33

pK of alfentanil:

Answer 33

6.5

Question 34

% nonionized (pH 7.4) of alfentanil:

Answer 34

89%

Question 35

Pb of alfentanil:

Answer 35

92%

Question 36

Clearance of alfentanil:

Answer 36

238 mL/min

Question 37

Vd of alfentanil:

Answer 37

27 L

Question 38

Partition coefficient of alfentanil:

Answer 38

129

Question 39

Et1/2 of alfentanil:

Answer 39

1.4 - 1.5 hrs

Question 40

Context sensitive t1/2 (4 hr infusion) of alfentanil:

Answer 40

60 min

Question 41

Effect-site equilibration time of alfentanil:

Answer 41

1.4 min

Question 42

pK of remifentanil:

Answer 42

7.3

Question 43

% nonionized (pH 7.4) of remifentanil:

Answer 43

58%

Question 44

Pb of remifentanil:

Answer 44

66 - 93%

Question 45

Clearance of remifentanil:

Answer 45

4,000 mL/min

Question 46

Vd of remifentanil:

Answer 46

30 L

Question 47

Et1/2 of remifentanil:

Answer 47

0.17 - 0.33 hrs

Question 48

Context sensitive t1/2 (4 hr infusion) of remifentanil:

Answer 48

4 min

Question 49

Effect-site equilibration time of remifentanil:

Answer 49

1.1 min