Exam 2 - Integumentary, Bone, Skeleton Flashcards
Functions of the skin
resistance to infection
sensory reception
thermoregulation
water retention
vitamin D synthesis
skin provides resistance to trauma and infections because:
it has a tough keratin exterior
dermatology
study and treatment of the integumentary system
keratinocyte
produces protein that increases durability of the skin
keratinocytes continually undergo mitosis because:
they are constantly flaking off the outer surface of the skin
dermis composed of:
connective tissue
epidermal ridges
downward extensions of the epidermis at the dermis and epidermal boundary
another name for hypodermis
subcutaneous layer
melanin
primary determinant of skin color
brown pigmentation
results from deposition of melanin by melanocytes
exposure to sunlight leads to
increased melanin production and darkening of the skin
cyanosis
condition in which the skin turns blue because of oxygen deficiency in the circulating blood
pallor
pale coloration in the skin
soft keratin vs. hard keratin
hard keratin is compact and crosslinked
hematoma
bruse
flexion lines
lines on palms, wrists, and elbows
mole
elevated patch of melanized skin
hair
thin filament of keratinized cells growing from a follicle
pilus
another name for individual hair
composition of hair and nails
dead, keratinized epidermal cells
examples of skin markings
flexion creases
friction ridges
pigmentation patches
thick skin
epidermis is .5 mm thick
thick stratum corneum
resists pressure and friction
found in palms and soles of feet
sweat glands but no hair
follicles or sebaceous glands
thin skin
epidermis is .1 mm thick
thin stratum corneum
hair, sebaceous glands, sweat glands
covers rest of the body
epidermis
keratinized stratified squamous epithelium
lacks blood vessels
depends on diffusion of nutrients from underlying connective tissue
sparse nerve endings for touch and pain
cells of epidermis
stem cells
keratinocytes
melanocytes
tactile (Merkel) cells
dendritic (Langerhans) cells
stem cells
undifferentiated
divide and produce keratinocytes
found in stratum basale
keratinocytes
majority of epidermal cells
synthesize keratin
melanocytes
stratum basale
synthesize melanin
long branching processes that spread among keratinocytes and continually shed melanin from tips
tactile (Merkel) cells
few in number
receptors for touch
basal layer of epidermis
associated with underlying dermal nerve fiber
dendritic (Langerhans) cells
stratum spinosum and stratum granulosum
immune cells that originate in bone marrow
migrate to epidermis and epithelia of oral cavity, esophagus, and vagina
carry fragments of foreign matter to lymph nodes to alert immune system
stratum basale
single layer of cuboidal to low columnar stem cells and keratinocytes resting on basement membrane
stratum spinosum
several layers of keratinocytes and is the thickest stratum everywhere but the palms and soles
deepest cells are capable of mitosis, but as they are pushed upward they cease dividing, produce more keratin filmanets
stratum granulosum
three to five layers of keratinocytes and some dendritic cells
stratum lucidum
thin translucent zone only in thick skin
keratinocytes densely packed with clear protein named eleiden
stratum corneum
30 layers of dead, scaly, keratinized cells that form durable surface layer
epidermal water barrier
a layer of dead keratinocytes between stratum granulosum and stratum spinosum
dermis
beneath epidermis
connective tissue layer
.2mm - 4mm thick
mostly collagen
blood vessels, cutaneous glands, nerve endings
dermal papillae
upward waves of dermis
epidermal ridges
downward waves of epidermis
papillary layer
layer of dermis
thin zone of areolar tissue in/near dermal papillae
loose tissue allows for leukocyte mobility
reticular layer
layer of dermis
dense irregular connective tissue
thick collagen bundles
stretching of the collagen fibers produce striae (stretch marks)
hypodermis
beneath the skin
more areolar and adipose tissue
pads body and binds skin to underlying tissue
highly vascular
subcutaneous fat
hypodermis composed mostly of adipose tissue
energy reservoir and thermal insulation
8% thicker in women
less in infants and elderly people (more sensitive to cold)
melanin
produced by melanocytes and accumulates in keratinocytes of stratum basale and stratum spinosum
eumelanin
brownish black
pheomelanin
reddish yellow
contains sulfur
erythema
abnormal redness of skin due to increased blood flow in dilated cutaneous blood vessels or dermal pooling of red blood cells that have escaped from abnormally permeable capillaries (sunburn)
albinism
genetic lack of melanin due to inherited recessive, nonfunctional tyrosinase gene
jaundice
yellowing of skin and whites of the eyes due to high levels of bilirubin in the blood
friction ridges
markings on fingertips
freckles
flat, melanized patches that vary with heredity and exposure to sun
mole
elevated patch of melanized skin
hemangiomas (birthmarks)
patches of discolored skin caused by benign tumors of the blood capillaries
accessory organs of skin
hair
nails
cutaneous glands
function of keratinocytes in stratum granulosum
production of filaggrin, a binding protein
production of a protective waterproof lipid
production of a protein sac around the keratin bundles
striae
stretching of collagen fibers of dermis, common during pregnancy or after weight gian
function of hair
UV protection
signals the presence of parasites
warms and insulates individual
types of hair
lanugo
vellus
terminal
lanugo hair
fine, downy, unpigmented hair of fetus
vellus hair
fine, pale hair
2/3 of women’s hair
1/10 of men’s hair
all hair of children except eyebrows, eyelashes, and scalp
terminal hair
longer, coarser, more heavily pigmented
eyebrows and eyelashes; scalp
after puberty: axillary and pubic hair; male facial hair; some hair on trunk and limbs
bulb of hair
swelling at the base where hair originates in the dermis of hypodermis
root of hair
remainder of hair within follicle
shaft of hair
portion above the skin surface
hair matrix
region of mitotically active cells above the papilla
hair’s growth center
layers of hair (cross section)
medulla
cortex
cuticle
medulla of hair
core of loosely arranged cells and air spaces
cortex of hair
most of the bulk of the hair with several layers of elongated keratinized cells that appear cuboidal to flattened in cross sections
cuticle of hair
composed of multiple layers of very thin, scaly, surface cells that overlap like roof shingle
follicle of hair
diagonal tube that dips deeply into dermis and sometimes as far as hypodermis
hair receptors
nerve fibers that entwine each follicle and respond to hair movements
piloerector muscle/pilomotor muscle/arrector pili
bundle of smooth muscle cells extending from dermal collagen fibers to the connective tissue root sheath of the follicle
texture of hair
related to differences in cross-sectional shape
straight: round
wavy: oval
tightly curled: flat
hair color
due to pigment granules in cortex
brown/black: rich in eumelanin
red: less eumelanin, rich in pheomelanin
blond: intermediate pheomelanin, little eumelanin
gray/white: absence of melanin, presence of air
function of torso/limb hair
vestigial but with sensory purpose
function of scalp hair
heat retention, sun protection
function of beard, pubic, axillary hair
indicate sexual maturity
associated with apocrine sweat glands
modulates dispersal of pheromones
function of guard hairs
protect nostrils and auditory canals
eyelashes protect eyes
function of eyebrows
enhances facial expression
reduce sun glare
keep perspiration from eyes
nails
derivatives of stratum corneum
very thin, dead, scaly cells with parallel keratin rows
sudoriferous glands
sweat glands
apocrine and merocrine
apocrine sudoriferous glands
groin, anal region, axilla, areola, beards of mature males
ducts open to hair follicle
sweat is thicker (more fatty acids)
develop with puberty
associated with sex pheromones
produce secretions via exocytosis
enlarge/shrink with menstrual cycle
merocrine sudoriferous glands
most numerous
perspiration
secrete to surface of skin via sweat pore
abundant on palms, soles, forehead, but all over
simple tubular gland located in dermis
3-4 million in skin
myoepithelial cells
properties similar to smooth muscle
contract in response to sympathetic nervous system and squeeze perspiration up the duct
sebaceous glands
produce oily secretion called sebum
usually open into hair follicle
holocrine secretion
keep hair/skin from becoming brittle
everywhere except thick skin (abundant on face/scalp)
secretions = broken down cells replaced around gland perimeter
ceruminous glands
auditory canal
cerumen (earwax - combo of sebum + dead epidermal cells)
keeps eardrums pliable
waterproofs canal
kills bacteria
coats guard hairs
mammary glands
produce milk during lactation
small traces in males and females
modified apocrine gland
senescence
age-related degeneration
hair grays, thins
melanocyte stem cells die out
mitosis slows
dead hairs not replaced
atrophy of sebaceous glands
skin becomes thinner, more translucent
skin and blood supply in aging
fewer, more fragile vessels
rosacea
increased bruising
rosacea
dilated blood vessels that causes reddened areas
thermoregulation in agin
vulnerability to hypothermia and heat stroke
skin cancer
induced by UV rays
elderly and fair-skinned most at risk
basal cell carcinoma
most common skin cancer
least dangerous (rarely metastasizes)
stratum basale (invades dermis)
appears as small, shiny bump and enlarges; develops central depression and beaded pearly edge
squamous cell carcinoma
arises from keratinocytes of stratum spinosum
can metastasize to lymph nodes
can be lethal
raised, reddened, scaly and later forms into concave ulcer with raised edges
chance of recovery is good with early detection and surgical removal
malignant melanoma
5% deadly
arises from melanocyte of existing mole
metastasizes quickly, fatal w/o treatment
average life expectancy is 6 months from diagnosis
greatest risk is UV exposure and family history
high incidence in men, redheads, people with severe childhood sunburns
ABCD rule
ABCD rule
asymmetry
border irregularity
color
diameter
burns
leading cause of accidental death
hyperthermal change to skin
death primarily from fluid loss, infection, toxic effects of eschar (dead tissue)
1st degree burn
partial thickness
only epidermis
localized
redness, slight edema, pain
sunburn
2nd degree burn
partial thickness
epidermis and part of dermis
red, tan, white
blistered, painful
may cause damage to hair follicles, nerve endings, cutaneous glands
sunburns and scalds
3rd degree burn
full thickness
epidermis and dermis completely destroyed
contracture and disfigurement
skin grafts
3rd degree burns have no dermis to regenerate
ideally comes from patient, but not always possible
allograft
skin graft from another person
xenograft
skin graft from another speices
compounds excreted in sweat
salts
urrea
ammonia
Cartilage
Embryonic forerunner of most bones
Covers many joint surfaces
Ligaments
Hold bone to bone at joint
Tendons
Attach muscle to bone
Skeletal system functions
Support
Movement
Protection
Blood formation
Electrolyte balance
Acid-base balance
Detoxification
Osteology
Study of bone
Mineralization/calcification
Hardening process of bone
Other tissue present in bone
Blood
Bone marrow
Cartilage
Adipose tissue
Nervous tissue
Fibrous CT
Long bones
Longer than wide
Ex: femur, humerus, phalanges
Short bones
Equal length and width
Ex: carpals and tarsals
Glide across one another, enabling wrist and ankle to flex in multiple directions
Flat bones
Not truly flat (curved)
Enclose and protect soft organs and provide broad surfaces for muscle attachment
Ex: scapula, ribs, sternum
Irregular bones
Elaborate shapes; not in any other category
Ex: vertebrae, sphenoid, ethmoid
Compact (dense) bone
Dense
White tissue that acts as outer shell
3/4 of skeleton
Spongy (cancellous) bone
Loosely organized
Spaces between bone tissue - filled with marrow
1/4 of skeleton
No central canals because blood supply near every osteocyte
Gives strength with little weight
Diaphysis
Shaft of long bone
Epiphysis
Expanded head at each end of long bones
Filled with spongy bone
Marrow (medullary) cavity
Empty space within cylinder of compact bone in diaphysis
Filled with bone marrow
Epiphyseal plate
Plate of hyaline cartilage that separates epiphysis and diaphysis
Zone where bone grows in length
Depleted in adults and replaced by epiphyseal line
Periosteum
Tough, outer fibrous layer of cartilage and inner osteogenic layer of bone forming cells that surrounds bone like a sheath
Fxn in bone growth and healing fractures
Nutrient foramina
Hole where blood vessels penetrate bone
Endosteum
Internal surface of bone with cells that deposit and dissolve bone
Diploe
Spongy bone in skull
Articular cartilage
Thin layer of hyaline cartilage that secretes lubricating fluid between bones
Osteogenic (osteoprogenitor) cells
Stimulated by stress/fractures to increase number of osteoblasts
Stem cells (endosteum, inner periosteum, central canal)
Osteoblasts
Reinforce/rebuild bone
Osteocytes
Former osteoblasts that become trapped in matrix they deposited
Mature bone cells that live in lacunae
Communicate via canaliculi
Resorb bone and deposit it
Osteoclasts
Bone-dissolving macrophages