Exam 2 Gut Microbiome Flashcards
Microbiome includes collection of microbes in/on
Skin
GI tract
Important of microbiome
Compete with pathogens Produce vitamins Digest indigestible foods Energy source for intestinal cells Talk to immune system Prevent over reaction and allow symbiosis
Most gut microbes present in
Large intestine
___ sample environment and determine whether to mount inflammatory response
Peyer’s Patches
Brain-gut-microbiota axis
Communication between brain-gut-enteric microbiota
Reduce anxiety, stress, depression
SCFA cause production of ___ to help control inflammation
TReg cells
_____ don’t release great deal of cytokines and deal with normal microbiota and “small attacks”
Non inflammatory macrophages in Lamina Propria
___ specifically designed for mucosal surfaces
IgA
IgA neutralizes invaders by binding to them in LP and escorting to ___
Lumen
IgA doesn’t cause inflammation because..
Doesn’t bind to and activate immune cells
Macrophages, lymphocytes, DCs, and IgA always on guard and deal wit invaders quickly to reduce
Inflammation
___ distributed thought GI tract
Educated B and T cells
DCs and WBCs activated in _____ and LP
Mesenteric lymph nodes
Default environment of GI tract
Anti-inflammatory
Intestinal epithelial cells produce
TGFbeta
