Exam 1 Cont.

Question 1

Place to show antigens to T cells

Answer 1

MHC

Question 2

Professional APCs

Answer 2

Dendritic cells
Macrophages
Experienced B cells

Question 3

2 methods of antigen presentation

Answer 3

MHC1

MHC2

Question 4

MHC1 allows us to see

Answer 4

What is being made in cells

Question 5

MHC 2 allows us to see what is happening

Answer 5

Outside cell

Question 6

Only ___ can use MHC2

Answer 6

APCs

Question 7

Almost ____ can use MHC 1

Answer 7

All cells

Question 8

____ constantly inspect presented fragments on MHCs

Answer 8

Killer T cells

Question 9

MHC 1 presents ordinary cell proteins, including ____, but they also present

Answer 9

Enzymes, structural proteins

Proteins encoded by viruses
Parasite proteins

Question 10

___ are normal cell enzymes that constantly chew up cellular proteins

Answer 10

Proteasomes

Question 11

Specific transport proteins that bring peptides to ER, where they are attached to MHC1 molecules

Answer 11

TAP1

TAP2

Question 12

Most peptides bound to MHC1 molecules are ____ long and the peptide is anchored to

Answer 12

8-11 AA

Both ends

Question 13

Extracellular proteins eaten by APCs are contained in

Answer 13

Phagosome

Question 14

Protein that protects binding area of MHC2

Answer 14

Invariant chain protein

Question 15

Most peptides bound to MHC2 are ___ long, and are anchored in the ___, allowing peptides to hang over

Answer 15

13-25

Center

Question 16

In addition to MHC2, APCs also provide ____ required for T cell activation

Answer 16

Co-stimulatory molecules

Question 17

Macrophages co-stimulatory protein ___ binds to ____ on Th

Answer 17

B7 binds to CD28

Question 18

2 signals that can activate dendritic cells

Answer 18

Chemical signals

• from dying cells
• from cells in battle (TNF)

Recognition of pathogen

Question 19

Activated dendritic cells leave area and go to nearest

Answer 19

Lymph node