Exam 2 Glomerular Filtration Flashcards
Glomerular filtrate also called filtrate is composed of what and filtered out of where
The fluid and solutes filtered out at the Bowman’s capsule
what is the Filtration fraction
The small amount of plasma that is filtered out at the glomerulus
Increase in filtration fraction is a sign of what disease?
Kidney disease
Production of filtrate in liters
Higher in which gender and why?
Between 150 and 180 l
Higher in males because males have higher BP
What two structures form the filtration membrane?
The glomerulus and the podocytes of the Bowman’s capsule
Filtration membrane permits what to pass through and prevent what to pass through and why
Permits the passage of water and small solute and prevents the passage of blood proteins and blood cells as they are larger
Glomerular endothelial cell type of the glamorous part of the filtration membrane and what they control
Are they the location fenestrations?
Simple squamous cells, the line blood vessels
Can contract to control BP?
They are the Location of fenestrations
Basal lamina
What it’s made of
Type of charge it has
What does it prevent from passing through?
Made of collagen
Has slightly negative charge
Prevents the passage of negatively charged molecules
Pressure of the kidneys versus the rest of the body
Three reasons why filtration is better in the kidneys
Glomerulus
Filtration membrane
The efferent arteriole
Pressure is the same but filtration is greater because of
The glomerulus creates a large surface area
Filtration membrane is very leaky with large spaces between the cells
Efferent arterial is smaller than the afferent arteriole increasing pressure in the glomerulus
What are Fenestrations
Gaps in the glomerular endothelial cells of the filtration membrane
Extensions of podocytes And purpose of them
Pedicels purpose is to increase surface area for filtration
Layers of the Bowman’s capsule
Inside layer is the visceral layer
Location of podocytes
Outside layer is the parietal layer
