Exam 2: Feline Herpesvirus-1 Flashcards
What are the structural components of FHV-1 virus
Enveloped,
Linear dsDNA
Icosahedral Capsid
Tegument
Glycoproteins
What is the function of the capsid
Protection of the nucleic acid
Induction of cell-mediated immunity (CMI)
What is the function of the tegument protein VP16
Initiation of DNA replication
What is the function of envelope glycoproteins
Attachment to cellular receptors
Induction of virus neutralizing antibodies
Who are the susceptible hosts of FHV-1
Domesticated cats and large cats such as tigers
What is the role of FeHV-1 in feline upper respiratory disease
Feline rhinotracheitis 45%
What are the main modes of virus transmission
Aerosol: oral, nasal, and ocular discharge are infectious for 7-21 days
Fomites
Asymptomatic carriers: latently infected: Reactivation takes place as a result of moving, parturition, boarding, nursing, or administration of corticosteroids
What is the pathogenesis of FeHV-1
Exposure
Replication in upper respiratory and conjunctival epithelium
Temperature sensitivity
Inflammatory response with cytokine production
High fever
What are the clinical signs of FeHV-1 (Feline Viral Rhinotracheitis)
Conjunctivitis and conjunctival
Hypersalivation
Sneezing
Possible dyspnea as a result of blockage of nasal passages
Keratitis
Dendritic ulcers in the cornea with possible perforation
Why can the infection of susceptible neonates be fatal
Generalized infection associated with high mortality in young kittens
High morbidity but low mortality in older kittens
What are the latency characteristics of FeHV-1
Lifelong
Neurons within the fifth cranial (trigeminal) nerve ganglia are the primary site of induction, maintenance, and reactivation of latent FeHV-1DNA
What are the samples you could take for FeHV-1
Virus isolation
PCR
Serology
Histopathology
Is their a current vaccine for FeHV-1
Yes
Prevents clinical signs
