Exam 2 - Erdman (full study guide)

Question 1

List all organisms that are gram positives.

Answer 1

Group strep
Viridans strep
PSSP
PRSP
Enterococcus
VRE (enterococcus)
MSSA
MRSA

Question 2

List all organisms that are anaerobes.

Answer 2

ADA
BDA
C. diff
Legionella
Treponema

Question 3

MOA: inhibit cell wall synthesis by binding to and inhibiting PBPs

Answer 3

Penicillins
Cephalosporins
Carbapenems
Monobactams

Question 4

MOA: inhibits DNA synthesis by inhibiting bacterial topoisomerases

Answer 4

FQ

Question 5

MOA: inhibits protein synthesis by IRREVERSIBLY binding to 30S ribosomal subunit

Answer 5

Aminoglycosides

Question 6

MOA: inhibits 2nd stage of cell wall synthesis by binding to D-Ala-D-Ala cell wall precursors

Answer 6

Vancomycin
Dalbavancin

Question 7

MOA: inhibits cell wall synthesis by binding to D-Ala-D-Ala cell wall precursors AND causes membrane depolarization by inserting lipophilic tail in cell wall

Answer 7

Telavancin
Oritavancin

Question 8

MOA: inhibits protein synthesis by binding to 50S ribosomal subunits

Answer 8

Quinupristin-dalfopristin
Clindamycin
Macrolides
Linezolid (near 30S)
Tedizolid (near 30S)

Question 9

MOA: causes membrane depolarization by inserting lipophilic tail in cell wall

Answer 9

Daptomycin

Question 10

MOA: inhibits protein synthesis by binding 30S ribosomal subunits

Answer 10

Tetracyclines
Tetracycline analogs

Question 11

MOA: sequential inhibition of microbial folic acid synthesis pathway by inhibiting bacterial dihydropteroate synthetase and dihydrofolate reductase

Answer 11

SMX-TMP

Question 12

MOA: binds to phospholipids in cell membrane causing displacement of Ca and Mg, which leads to changes in cell wall permeability and leakage of cellular contents

Answer 12

Polymyxins

Question 13

MOA: prodrug activated by ferredoxins whose activated metabolites damage bacterial DNA

Answer 13

Metronidazole

Question 14

When cidal, does it kill in time or conc. dependent manner? (penicillins)

Answer 14

time

Question 15

When cidal, does it kill in time or conc. dependent manner? (cephalosporins)

Answer 15

time

Question 16

When cidal, does it kill in time or conc. dependent manner? (carbapenems)

Answer 16

time

Question 17

When cidal, does it kill in time or conc. dependent manner? (monobactams)

Answer 17

time

Question 18

When cidal, does it kill in time or conc. dependent manner? (macrolides)

Answer 18

time

Question 19

When cidal, does it kill in time or conc. dependent manner? (vancomycin)

Answer 19

time

Question 20

When cidal, does it kill in time or conc. dependent manner? (dalbavancin)

Answer 20

time

Question 21

When cidal, does it kill in time or conc. dependent manner? (quinupristin-dalfopristin)

Answer 21

time

Question 22

When cidal, does it kill in time or conc. dependent manner? (linezolid)

Answer 22

time

Question 23

When cidal, does it kill in time or conc. dependent manner? (tetracyclines and their analogs)

Answer 23

time

Question 24

When cidal, does it kill in time or conc. dependent manner? (SMX-TMP)

Answer 24

time

Question 25

When cidal, does it kill in time or conc. dependent manner? (clindamycin)

Answer 25

time

Question 26

When cidal, does it kill in time or conc. dependent manner? (FQ)

Answer 26

conc.

Question 27

When cidal, does it kill in time or conc. dependent manner? (aminoglycosides)

Answer 27

conc.

Question 28

When cidal, does it kill in time or conc. dependent manner? (azithromycin)

Answer 28

time usually, but conc. against some organisms

Question 29

When cidal, does it kill in time or conc. dependent manner? (tedizolid)

Answer 29

conc.

Question 30

When cidal, does it kill in time or conc. dependent manner? (daptomycin)

Answer 30

conc.

Question 31

When cidal, does it kill in time or conc. dependent manner? (telavancin)

Answer 31

conc.

Question 32

When cidal, does it kill in time or conc. dependent manner? (oritavancin)

Answer 32

conc.

Question 33

When cidal, does it kill in time or conc. dependent manner? (polymyxins)

Answer 33

conc.

Question 34

When cidal, does it kill in time or conc. dependent manner? (metronidazole)

Answer 34

conc.

Question 35

CA-MRSA SSTIs ABx

Answer 35

clindamycin TMP-SMX delafloxacin

Question 36

MRSA ABx

Answer 36

1. vanco 2. quinupristin-dalfopristin 3. linezolid, tedizolid 4. daptomycin 5. telavancin, dalbavancin, oritavancin 6. ceftaroline 7. minocycline, tetracycline analogs

Question 37

Pseudomonas aeruginosa Abx

Answer 37

1. Ticarcillin 2. Piperacillin 3. Zosyn 4. ceftazidime, cefepime, cefiderocol 5. aztreonam 6. ciprofloxacin, levofloxacin, delafloxacin 7. gentamicin, tobramycin, amikacin 8. colistin, polymyxin B

Question 38

Legionella Abx

Answer 38

FQs (Ciprofloxacin, Levofloxacin, Moxifloxacin, Delafloxacin) Macrolides (erythromycin, clarithromycin, azithromycin) Tetracyclines (tetracycline, doxycycline, minocycline)

Question 39

C. diff Abx

Answer 39

Vancomycin Metronidazole

Question 40

below diaphragm anaerobes (BDA) ABx

Answer 40

1. Unasyn 2. Augmentin 3. Zosyn 4. cefoxitin, cefotetan (2nd gen) 5. carbapenems 6. tige-, era-, omadacycline 7. clindamycin 8. metronidazole

Question 41

PRSP ABx

Answer 41

1. ceftriaxone, cefotaxime 2. cefiderocol 3. ceftaroline 4. levo, moxi, delafloxacin 5. vancomycin 6. quinupristin-dalfopristin 7. linezolid 8. tedizolid 9. dapto 10. telavancin 11. dalbavancin 12. oritavancin

Question 42

Which ABx should not be used with warfarin?

Answer 42

1. FQs (levo, moxi, cipro, dela) 2. erythromycin and clarithromycin 3. metronidazole 4. SMX-TMP -increases bleeding risk

Question 43

drug of choice for MSSA

Answer 43

Nafcillin

Question 44

drug of choice for P. aeruginosa

Answer 44

ticarcillin

Question 45

drug of choice for MRSA

Answer 45

vancomycin