Exam 2 - Agonist & Antagonists of Nicotine Receptors

Question 1

Another name of anti-nicotinic drugs?

Answer 1

ganglion blocking drugs

Question 2

What is the function of anti-nicotinic (ganglion blocking) drugs?

Answer 2

prevent nicotinic physiological responses to acetylcholine
* action potential firing
* muscle contractions

Question 3

What are examples of anti-nicotinic drugs?

Answer 3

• mecamylamine
• trimethaphan

Question 4

Where do ganglion blocking drugs work?

Answer 4

inhibit Nn-mediated neurotransmission in both sympathetic and parasympathetic ganglia

Question 5

Why do ganglionic blocking drugs work on both the SNS and PNS?

Answer 5

lack of selectivity

Question 6

Ganglion blocking drugs’ lack of selectivity leads to:

Answer 6

broad effects with limited clinical use

Question 7

What disorders are ganglionic blocking drugs used to treat?

Answer 7

• severe hypertension
• atherosclerosis
  both adjunct therapies

Question 8

What are common side effects of anti-nicotinic drugs?

Answer 8

the opposite of the normal effects of the predominating system (SNS or PNS)

Question 9

How does nicotine affect the autonomic nervous system?

Answer 9

nicotine is an addictive drug that affects both the CNS and PNS

Question 10

Nicotine

Answer 10

agonist of the Nn receptor and promotes postganglionic neurotransmission

Question 11

What happens with a nicotine overdose?

Answer 11

elicits dominant autonomic effects
* in the peripheral nervous system = increased HR and BP
* in the central nervous system = convulsions