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Pharmacology > Athersclerosis Drugs > Flashcards

Athersclerosis Drugs Flashcards

1
Q

Resins

A
  • cholestyramine
  • reduced LDL levels by increasing bile acid secretion and indirectly live bile acid production
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2
Q

Niacin

A

decreases LDL levels indirectly by preventing liver production of one of its precursors VLDL

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3
Q

statins

A
  • lovestatin (activated by first pass metabolism through liver
  • decreases LDL by inhibiting de novo hepatocyte cholesterol production by HMG-CoA
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4
Q

ezetimibe

A

inhibits cholesterol uptake into the intestine (beneficial combo with statins)

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5
Q

PCSK9

A
  • binds the LDL receptor causing its degradation and preventing cholesterol uptake
  • alirocumab (antibody) : inhibits PCSK9 increasing the number of LDL receptors on the surface of the liver
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6
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A
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Pharmacology (12 decks)

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