Exam 1 - Drug Receptor Families & Cell Signaling

Question 1

ligand

Answer 1

a molecule that binds to a specific site on a target protein to form a complex

Question 2

receptor

Answer 2

a protein or protein complex located on the surface of a cell or within a cell that specifically binds to a ligand

Question 3

endocrine signaling

Answer 3

secreted ligands enter the bloodstream and are carried to distant receptor-containing target cells.

Question 4

paracrine

Answer 4

igands, secreted by the signaling cell, act on neighboring, receptor-containing cells

Question 5

autocrine

Answer 5

a cell secretes a ligand and responds/expresses receptors for that ligand

Question 6

synaptic

Answer 6

ligands, secreted by a neuron, act on receptors expressed on the
adjacent cell in the synapse

Question 7

contact-dependent

Answer 7

membrane-bound ligands act on neighboring, receptor-
containing cells.

Question 8

What are the five main cell signaling receptor families that are targeted by drugs?

Answer 8

1. ion channels
2. transporters
3. enzymes or enzyme-containing.-associated receptors
4. nuclear receptors
5. G protein-coupled