Exam 2 Flashcards
signal transduction
converts information from signal into cellular response
ligand
binds to receptor protein making the cell respond; the signaling molecule
Animal cell signals
- Hormones, peptide (insulin) or steroid (estrogen)
- Neurotransmitters (catecholamine)
- Cytokines (interleukins)
Plant cell signals
- Hormones (auxin, gibberellin, brassinosteroid)
- Red light
- Blue light
intracellular receptor
- steroid hormones
- cytoplasm
- nonpolar; bind to lipid-soluble ligands (hydrophobic)
- can easily cross plasma membrane and bind to a cytoplasmic protein
cell surface/membrane receptor
3 types:
- channel linked- ion channel that opens in response to a ligand
- enzymatic- an enzyme activated by ligand
- G protein-coupled- bound to GTP and assists in transmitting signal
- water soluble; cannot cross membrane
- outside cell (cytoplasm + environment)
How to turn receptors on/off
- On: Add a phosphate from ATP (Kinase)
Off: Remove a phosphate (phosphatase) - On: add GTP (GEF trades GDP for GTP)
Off: release P (GAP)
second messenger
alter behavior of cellular proteins by binding to them and changing their shape
- cyclic-AMP(cAMP)
- calcium/calmodulin
Steroid receptor’s 3 domains
- hormone-binding
- DNA- binding
- a domain that can interact with coactivators to affect the level of gene transcription
substrate
molecule that undergo reaction
active site
region of the enzyme that binds to substrate
allosteric enzymes
possess allosteric site where molecules other than the substrate can bind
-active or inactive site
cofactor
usually metal ions that bind to a protein to make it active
coenzyme
- non-protein organic molecules
- electron donor or acceptor in redox reaction
biochemical pathway
a series of reactions in which a product of one reaction becomes the substrate for the next