Exam 2 Flashcards
What is pulmonary circulation?
The flow of blood from the right side of the heart, to the lungs, and back to the left side of the heart.
What is the systemic circulation?
The flow of blood from the heart, to the tissues, and then back to the heart.
Endocrinology is the study of what?
The glands and hormones of the body and their related disorders.
Endo- means?
Within
Crin- means?
Secretion
-ology means?
Study of
Secretion whose effects are very localized?
Paracrine agents
Chemical messengers; small concentration; physiologic responses
Hormones
Chemical classes of Hormones (Classic)?
- Peptides: (2 or more amino acids chained together….peptide bond.
- Steroids: begins as cholesterol
- Amines: biochemical modifications of a single amino acid, tyrosine.
Signaling molecules that are derivatives of long-chain fatty acids, usually arachadonic acid, made by every cell of the body
Eicosanoids
Four families of eicosanoids?
- Prostaglandins
- Prostacyclin
- Leukotrienes
- Thromboxane
Blood vessel diameter, inflammation, blood clotting, uterine contraction during parturition and ovulation
Prostaglandins
Inhibits platelet activation
Prostacyclin
Allergic rx, increases vascular permeability and induces airway constriction
Leukotrienes
Increases blood clotting and platelet stickiness
Thromboxane
A form of signaling in which a cell secretes a chemical messenger (called the autocrine agent) that signals the same cell.
Autocrine signaling
An example of an autocrine agent?
The cytokine interleukin-1 in monocytes. When this is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it.
A form of cell signaling in which the target cell is close to the signal releasing cell?
Paracrine signaling
Examples of paracrine signaling agents?
Include growth factor and clotting factors.
Growth factor signaling plays an important role in may aspects of _____.
Development