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Cell Bio > Exam 2 > Flashcards

Exam 2 Flashcards

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Biology 101 flashcards
1
Q

The following is true regarding transcriptionally active chromatin:
a) The nucleosomes are in the heterochromatic state.
b) The HdAC has stimulated Activators.
c) HAT proteins are active.
d) Methyl binding proteins are needed.

A

HAT proteins are active

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2
Q

The following is not needed for the transcription of a gene needed for cell survival:
a) Euchromatin
b) CpG islands
c) RNA polymerase
d) Basal transcription factors

A

CpG islands

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3
Q

The following would not be included as a part of a transcript from a gene:
a) A 3’ UTR
b) TATA box
c) An intron
d) Kozac sequence

A

TATA box

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4
Q

The CpG island of a gene promoter___:
a) Can bind to the basal transcription site.
b) Causes euchromatin.
c) Attracts transcription factors.
d) Can stimulated chromosome compaction.

A

can stimulated chromosome compaction

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5
Q

The correct sequence position of the following DNA elements in a gene and its promoter is: (Hint: The relative location of the DNA sequences do not necessarily have to be adjacent to one another.)

a) 3’-TATA -> start nucleotide -> intron -> UTR - 5’
b) 5’- Exon1 -> Intron 1 -> TATA-> UTR - 3’
c) 5’-TATA -> start nucleotide -> Intron 2 -> UTR - 3’
d) 3’ Enhancer-> TATA -> Exon 1-> Intron 5 -3’

A

c) 5’-TATA -> start nucleotide -> Intron 2 -> UTR - 3’

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6
Q

The following protein would be predicted to have an tRNA binding domain:
a) eIF 2
b) TFIID
c) An activator
d) EF 4E protein

A

a) eIF 2

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7
Q

During translation elongation using the mRNA encoding the 60S ribosomal subunit, the following is true:
a) Peptidyl transferase is active.
b) Ribosomes do not undergo translation.
c) Histone deacetylase (HDAC) is active at the enhancer site.
d) The ribosome binds to the Shine/Delgarno sequence.

A

peptidyl transferase is active

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8
Q

The following is reasonable to assume regarding a mature mRNA encoding histone 2A.
a) Its signal is cleaved after delivery to the nucleus.
b) It has not been spliced yet.
c) It is controlled by proteins that attract the matrix stimulating factor.
d) It interacts with proteins having an NES.

A

it interacts with proteins having an NES

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9
Q

The following is false of Lysosome Storage Diseases
a) A mutation may be on a hydrolase.
b) Waste products build up in the cell.
c) A mutation may be on the 40S subunit.
d) The infant may die at a very early age.

A

A mutation may be on the 40S subunit

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10
Q

The following happens to vesicle transported proteins that are secreted:
a) Translation occurs in the nuclear membrane.
b) Translation is halted until the ribosome locates the TOM receptor.
c) They get unfolded for entry into the translocon.
d) Their release involves complexin.

A

their release involves complexin

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11
Q

Secreted proteins _________
a) Are carried by the SRP to the translocon.
b) Have stop-transfer signal sequences.
c) Leave the cell through a specialized channel.
d) Travel in vesicles that have matrix targeting sequences.

A

are carries by the SRP to the translocon

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12
Q

The following is false of the TOM40 receptor:
a) It interacts with the MSF.
b) It interacts with the TOM channel protein.
c) It interacts with a protein that has an NES sequence.
d) It is involved in mitochondrial entry.

A

it interacts with a protein that has an NES sequence

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13
Q

The following is false regarding transport of a protein into the nucleus.
a) The protein could be a heterodimer.
b) The protein has an internal peptide targeting sequence.
c) Ran must be in its GTP bound state.
d) The NLS sequence gets recognized by importin-alpha

A

c) Ran must be in its GTP bound state.

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14
Q

____________ is a method for identification of a specific protein.

A

Western

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15
Q

______________ are proteins that attach peptides to GPI anchors.

A

Transamidase

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16
Q

_______ is a sequence needed for basal transcription of genes.

A

TATA

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17
Q

_________________is a motif used by a transcription factor to identify a specific nucleic acid sequence.

A

Alpha helix

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18
Q

_______________ is the catalytic site for covalent bond synthesis between amino acids.

A

peptidyl transferase site

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19
Q

______ is a protein that allows movement of the ribosome on the mRNA.

A

EF-G

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20
Q

_________ allows for GTP/GDP exchange in nuclear transport.

A

RAN-GAP

21
Q

_____________ is an enzyme that can covalently bind a sugar to an amino acid.

A

Oligotransferase

22
Q

__________ is a non-standard nucleotide contained on tRNA.

A

Wobble Base

23
Q

____ is the DNA element that ensures nearby genes are not regulated by the same promoter.

A

Insulator

24
Q

____ is the most prominent gene sequence found in a population and generally is not associated with a disease.

A

Wild Type

25
Q

___ is the bridge protein between the PABP and eIF4E .

A

eIF4G

26
Q

___ is the bond catalyzed by the ribosome.

A

Pepetide

27
Q

__________ is the organelle that needs the M6P structure for targeting.

A

Lysosome

28
Q

_______ is an experimental technique that would be used to determine if histones are targeted to the nucleus.

A

Immunofluorescence

29
Q

The following is true regarding euchromatin.
A: It is compacted
B: Basal transcription factors can bind to the TATA Box.
C: HdAC makes chromatin available for activator binding.
D: Methyl transferase would be active.

A

Basal transcription factors can bind to the TATA box.

30
Q

______ is the enzyme active in transcription elongation of tRNA.
A: DNA POL III
B: RNA POL III
C: RNA POL I
D: DNA POL I

A

RNA POL III

31
Q

_______ is the technique that would be used to determine where in the genome a known transcription factor would bind. (remember a given TF may have several genes that it regulates).
A: Northern Blotting
B: Southern Analysis
C: ChIP
D: Immunofluorescence

A

ChIP

32
Q

______ is the term for the entry location of the tRNA in the ribosome.
A: Peptidyltransferase site
B: Aminoacyl Site
C: TATA box
D: COO- (carboxyl) end

A

Aminoacyl Site

33
Q

The following is the correct order in transcription initiation.
A: HAT activity –>Coactivator Binding–> TFIIH activity —>Mediator interaction

B: HAT activity –>Coactivator Binding–> Mediator interaction –> TFIIH activity

C: Mediator interaction —> HAT activity –>Coactivator Binding–> TFIIH activity

D: HaDC activity –>Basal TF binding –> Coactivator Binding–> TFIIH activity

A

B: HAT activity –>Coactivator Binding–> Mediator interaction –> TFIIH activity

34
Q

______ is the protein that interacts with the mGuanine cap.
A: EF-Tu
B: eIF4E
C: eIF4A
D: EF-G

A

eIF4E

35
Q

________ is a protein that recognizes a tRNA for delivery to the Ribosome.
A: TFIID
B: EF G
C: eIF A
D: EF Tu

A

EF Tu

36
Q

_______ is the type of Experiment used by Beadle-Tatum.
A: Northern Blotting
B: Nutrient testing
C: Single nucleotide induction
D: Loss of Function Mutants

A

Loss of Function Mutants

37
Q

_______ are the family of proteins that make distal promotors accessible for transcription initiation.
A: Structural Maintenance of Chromatin
B: TFII Complex
C: Regulatory TF Elements
D: HdACs

A

Structural Maintenance of Chromatin

38
Q

________ is the protein that carries a protein to the mitochondria.
A: TOM receptor
B: Matrix Stimulating Factor
C: RAN-GTP
D: Matrix Targeting Signal

A

Matrix Stimulating Factor

39
Q

_______ is the eukaryotic protein containing the enzymatic activity for making a peptide bond.
A: 50S Subunit
B: EF-tu
C: Aminoacyl site
D: 60S Subunit

A

60S Subunit

39
Q

_______ is the eukaryotic protein containing the enzymatic activity for making a peptide bond.
A: 50S Subunit
B: EF-tu
C: Aminoacyl site
D: 60S Subunit

A

60S Subunit

40
Q

________ amino acid is encoded in the start codon AUG
A: Leucine
B: Arginine
C: Methionine
D: Glycine

A

Methionine

41
Q

________ is the organelle that a protein with the sequence NH3–AAGCKHKHNNTIL–COO would go to.
A: RER
B: Peroxisome
C: Mitochondria
D: Nucleus

A

Nucleus

42
Q

__________ is the protein that synthesis a GPI anchor.
A: 80S Ribosome
B: Transamidase
C: Signal Peptidase
D: Oligotransferase

A

Transmidase

43
Q

_______ a protein that would would interact with the Signal Recognition Particle Receptor.
A: RAN Binding Protein
B: Insulin
C: Matrix Stimulating Factor
D: ATP synthase

A

Insulin

44
Q

________ is the lattice structure that interacts with the M6P Receptor.
A: Clathrin
B: Hydrolase
C: Peroxidase
D: Stop-Transfer Anchors

A

Clathrin

45
Q

_______ is a protein that works with T-SNARES and Complexin for vesicle fusion.
A: M6P Receptor
B: TOM40
C: Syntaxin
D: Clatharin

A

Syntaxin

46
Q

________ is a protein that recognizes an internal peptide sequence consisting of a cluster of basic amino acids.
A: RAN-GAP
B: Matrix Stimulating Factor
C: SRP
D: alpha-importin

A

Alpha-importin

47
Q

The following protein would need to be unfolded to enter its organelle.
A: Na Ion Channel
B: Histone 2A
C: ATP Synthase
D: A hydrolase

A

ATP Synthase

48
Q

________ is a protein not involved in Nuclear Localization.
A: RAN-GAP
B: Importin
C: Transamidase
D: RAN

A

Transmidase

Cell Bio (6 decks)

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